公开(公告)号：CA2549737A1

公开(公告)日：2005-05-26

申请号：CA2549737

申请日：2004-11-10

Applicant: TORAY INDUSTRIES

Inventor： TANIGUCHI TAKASHI ,  ARAKI MIHO ,  SUGIHARA YUKIKO ,  KIMURA AKIO ,  TANAHASHI KAZUHIRO ,  NAKAMURA MASATSUGU

IPC: A61K47/36 ,  A61K9/00 ,  G02C13/00

Abstract: A composition excelling in safety that when locally administered to mammals, can be uniformly dispersed over the mucous tissue; and an ophthalmic solutio n containing the composition that can stabilize the tear film and can keep the tear film on the surface of the eyeball smoothed. There is provided an ophthalmic solution comprised of an agar-containing composition, the composition comprising as essential components a polysaccharide, especially agar, and water, wherein upon centrifugal separation with 40,000.times.g by means of a centrifugal separator, the amount of precipitated agar is less th an 65 wt.% based on the total amount of agar contained. It is found from result s of a corneal surface crook index change test that this ophthalmic solution h as an excellent tear film stabilizing activity. Therefore, this agar-containing ophthalmic solution exhibits an effect of sustaining the tear film on the surface of the eyeball in stable form over a prolonged period of time and th us can be used as an artificial tear fluid.