公开(公告)号：DE60122555T2

公开(公告)日：2007-07-12

申请号：DE60122555

申请日：2001-09-25

Applicant: TORAY INDUSTRIES

Inventor： TAKAHASHI TOSHIYA ,  ISHIGAKI TAKESHI ,  FUNAHASHI MIYUKI ,  TANIGUCHI KOJI ,  KANEKO MASAYUKI ,  KAINOH MIE ,  MEGURO HIROYUKI

IPC: C07D471/10 ,  A61K31/438 ,  A61K31/4545 ,  A61K31/499 ,  A61K31/55 ,  A61P1/04 ,  A61P1/16 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P19/02 ,  A61P27/14 ,  A61P27/16 ,  A61P29/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00

Abstract: Disclosed are novel spiro derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases. The spiro derivative according to the present invention has the chemical structure, for example, represented by the following Formula (31):

公开(公告)号：ES2271071T3

公开(公告)日：2007-04-16

申请号：ES01967819

申请日：2001-09-25

Applicant: TORAY INDUSTRIES

Inventor： TAKAHASHI TOSHIYA ,  ISHIGAKI TAKESHI ,  FUNAHASHI MIYUKI ,  TANIGUCHI KOJI ,  KANEKO MASAYUKI ,  KAINOH MIE

IPC: C07D471/10 ,  A61K31/438 ,  A61K31/4545 ,  A61K31/499 ,  A61K31/55 ,  A61P1/04 ,  A61P1/16 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P19/02 ,  A61P27/14 ,  A61P27/16 ,  A61P29/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00

Abstract: Derivado espiro representado por la **Fórmula**, en la que I y m representan independientemente números enteros de 0 a 2; n representa 1, A representa un átomo de oxígeno, -CH-, carbono con un doble enlace o un átomo de nitrógeno (con la condición de que cuando A es un átomo de oxígeno, R3 no existe), B representa un grupo CH2 o NH, C'' y D representan hidrógeno, o C'' y D representan cooperativamente oxo; X1 e Y1 representan independientemente hidrógeno, halógeno, alquilo C1-C8, alcoxi C1-C8, ciano, nitro, hidroxilo, amino o tetrazolilo; R1 y R2 representan independientemente hidrógeno o alquilo lineal C1-C6; R3 y R4 representan independientemente hidrógeno, alquilo lineal C1-C6, alquilo ramificado C3-C8, o fenilo o bencilo, estando este fenilo o bencilo sustituidos con 0 a 2 sustituyentes seleccionados del grupo que consiste en halógeno, alquilo C1-C8, alcoxi C1-C8, ciano, nitro, hidroxilo, amino y tetrazolilo; F representa ¿CH2- o ¿C(O)-; cuando A es un átomo de nitrógeno o una sal farmacéuticamente aceptable del mismo.

公开(公告)号：CA2423007A1

公开(公告)日：2003-03-24

申请号：CA2423007

申请日：2001-09-25

Applicant: TORAY INDUSTRIES

Inventor： KAINOH MIE ,  TANIGUCHI KOJI ,  MEGURO HIROYUKI ,  ISHIGAKI TAKESHI ,  TAKAHASHI TOSHIYA ,  FUNAHASHI MIYUKI ,  KANEKO MASAYUKI

IPC: A61P1/04 ,  A61P1/16 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P19/02 ,  A61P27/14 ,  A61P27/16 ,  A61P29/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D471/10 ,  A61K31/438 ,  A61K31/4545 ,  A61K31/499 ,  A61K31/55

Abstract: Disclosed are novel spiro compounds and their use as drugs, particularly adhesion molecule inhibitors useful in the treatment of inflammatory disease s. An example of the spiro compounds has a chemical structure represented by formula (31).

公开(公告)号：CA2422135A1

公开(公告)日：2003-03-13

申请号：CA2422135

申请日：2001-09-14

Applicant: TORAY INDUSTRIES

Inventor： TANIGUCHI KOJI ,  KANEKO MASAYUKI ,  FUNAHASHI MIYUKI ,  ISHIGAKI TAKESHI ,  TAKAHASHI TOSHIYA ,  KAINOH MIE ,  MEGURO HIROYUKI

IPC: A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C275/26 ,  C07D233/54 ,  C07D235/02 ,  C07D239/36 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/10 ,  C07D491/107 ,  C07D495/10 ,  A61K31/175 ,  C07D239/47 ,  A61K31/506 ,  A61K31/513 ,  A61K31/55

Abstract: A novel urea derivative and a medicinal application thereof, especially as a n adhesive-molecule inhibitor useful for the treatment of inflammatory disease s. The urea derivative, for example, has the chemical structure represented by the following formula (35).

公开(公告)号：AU8811401A

公开(公告)日：2002-04-02

申请号：AU8811401

申请日：2001-09-25

Applicant: TORAY INDUSTRIES

Inventor： TAKAHASHI TOSHIYA ,  ISHIGAKI TAKESHI ,  FUNAHASHI MIYUKI ,  TANIGUCHI KOJI ,  KANEKO MASAYUKI ,  KAINOH MIE ,  MEGURO HIROYUKI

IPC: A61P1/04 ,  A61P1/16 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P19/02 ,  A61P27/14 ,  A61P27/16 ,  A61P29/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D471/10 ,  A61K31/438 ,  A61K31/4545 ,  A61K31/499 ,  A61K31/55

Abstract: Disclosed are novel spiro derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases. The spiro derivative according to the present invention has the chemical structure, for example, represented by the following Formula (31):

公开(公告)号：CA2278030A1

公开(公告)日：1999-05-27

申请号：CA2278030

申请日：1998-12-11

Applicant: TORAY INDUSTRIES

Inventor： TAKAHASHI TOSHIYA ,  SAITO NOBUO ,  TAKESHIGE HIDEYUKI ,  TANAKA TOSHIAKI ,  KAINOH MIE

IPC: A61K38/12 ,  C07K7/64

Abstract: Cyclic peptides represented by general formula (I) and having VLA-4 adhesion inhibitory activities, and the use thereof as remedies for allergic inflammations or hepatitis. In said formula, A and F represent each Cys, Asp, etc.; B represents Ala etc.; C represents Asp analog etc.; D represents Tyr etc.; E represents Leu etc.; G represents a disulfide or amide linkage; R1 represents hydrogen or acyl; and R2 represents hydrogen or alkyl.

公开(公告)号：NO174668C

公开(公告)日：1994-06-15

申请号：NO892499

申请日：1989-06-15

Applicant: TORAY INDUSTRIES

Inventor： OHNO KIYOTAKA ,  TAKAHASHI TOSHIYA ,  OHTAKE ATSUSHI ,  WAKITA HISANORI ,  NISHIO SHINTARO

IPC: C07D307/93 ,  C07D407/14 ,  C07D493/04

Abstract: 2,5,6,7-Tetranor-4,8-inter-m-phenylene PGI2 derivatives such as 16-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 and its methyl ester, 17-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 and its methyl ester, 15-phenyl-2,5,6,7,16,17,18,19,20-nonanor-4,8-inter-m-phenylene PGI2, 16-methyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI2, 16,16-dimethyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI2, 16-methyl-16-phenoxy-2,5,6,7,17,18,19,20-octanor-4,8-inter-m-phenylene PGI2, 16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI2 and its methyl ester and 3-decarboxy-3-hydroxymethyl-16-methyl-16-phenoxy-2,5,6,7,18,19,20-hept anor-4,8-inter-m-phenylene PGI2, useful as medicines, are disclosed. These derivatives are useful as, for example, antiulceric agents, hypotensives, and antithrombotic agents.

公开(公告)号：DE3886936T2

公开(公告)日：1994-04-28

申请号：DE3886936

申请日：1988-10-14

Applicant: TORAY INDUSTRIES

Inventor： OHNO KIYOTAKA ,  TAKAHASHI TOSHIYA ,  OHTAKE ATSUSHI ,  WAKITA HISANORI ,  NISHIO SHINTARO

IPC: C07D307/93 ,  C07D407/14 ,  C07D493/04 ,  A61K31/557 ,  C07D407/12

Abstract: 2,5,6,7-Tetranor-4,8-inter-m-phenylene PGI2 derivatives such as 16-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 and its methyl ester, 17-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 and its methyl ester, 15-phenyl-2,5,6,7,16,17,18,19,20-nonanor-4,8-inter-m-phenylene PGI2, 16-methyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI2, 16,16-dimethyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI2, 16-methyl-16-phenoxy-2,5,6,7,17,18,19,20-octanor-4,8-inter-m-phenylene PGI2, 16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI2 and its methyl ester and 3-decarboxy-3-hydroxymethyl-16-methyl-16-phenoxy-2,5,6,7,18,19,20-hept anor-4,8-inter-m-phenylene PGI2, useful as medicines, are disclosed. These derivatives are useful as, for example, antiulceric agents, hypotensives, and antithrombotic agents.

公开(公告)号：AT73768T

公开(公告)日：1992-04-15

申请号：AT87118053

申请日：1987-12-07

Applicant: TORAY INDUSTRIES

Inventor： OHNO KIYOTAKA ,  TAKAHASHI TOSHIYA ,  NISHIO SHINTARO

IPC: A61K31/34 ,  A61K31/557 ,  A61P1/04 ,  A61P7/02 ,  A61P9/08 ,  A61P11/08 ,  A61P15/04 ,  A61P43/00 ,  C07C405/00 ,  C07D307/93

Abstract: Disclosed herein are novel prostaglandin I2 (PGI2) derivatives exhibiting excellent physiological activities, said derivatives being represented by the general formula: wherein R1, R2 and R3 are as defined herein. )

公开(公告)号：AU8242087A

公开(公告)日：1988-06-16

申请号：AU8242087

申请日：1987-12-10

Applicant: TORAY INDUSTRIES

Inventor： OHNO KIYOTAKA ,  TAKAHASHI TOSHIYA ,  NISHIO SHINTARO

IPC: A61K31/34 ,  A61K31/557 ,  A61P1/04 ,  A61P7/02 ,  A61P9/08 ,  A61P11/08 ,  A61P15/04 ,  A61P43/00 ,  C07C405/00 ,  C07D307/93

Abstract: Disclosed herein are novel prostaglandin I2 (PGI2) derivatives exhibiting excellent physiological activities, said derivatives being represented by the general formula: wherein R1, R2 and R3 are as defined herein. )