公开(公告)号：US3645928A

公开(公告)日：1972-02-29

申请号：US3645928D

申请日：1969-07-16

Applicant: TORAY INDUSTRIES

Inventor： WAKAMURA NOBUO ,  TANAKA TAKASHI ,  OKADA HIROSHI ,  OSAKADA ATSUSHI

IPC: C08G69/20 ,  C08J9/04 ,  C08J1/20 ,  C08J1/26

CPC classification number: C08J9/04 ,  C08G69/20 ,  C08J2377/02

Abstract: AN IMPROVED PROCESS IS PROVIDED FOR THE PREPARATION OF POLYLACTAM FOAMS IN WHICH E-CAPROLACTAM OR A MIXTURE OF LACTAMS CONTAINING MORE THAN 50 MOL PERCENT OF E-CAPROLACTAM IS ANIONICALLY POLYMERIZED IN THE PRESENCE OF AN ALKALI CATALYST, A BLOWING AGEN AND A PROMOTER AT A TEMPERATURE OF ABOUT 100-180*C. THE IMPROVED PROCESS IS PARTICULARLY CHARACTERIZED BY THE USE OF A PROMOTER WHICH WHEN ADDED TO A MIXTURE OF LACTAM AND ALKALI CATALYSTS CAUSES THE MIXTURE TO SOLIDIFY DUE TO CRYSTALLIZATION WITHIN 3 MINUTES AND TO PRODUCE A POLYLACTAM HAVING A RELATIVE VISCOSITY OF AT LEAST 3 WHEN A CONVERSION REACHES EQUILIBRIUM. THE POLYLACTAM FOAMS OF THIS INVENTION EXHIBIT IMPROVED MECHANICAL AND CHEMICAL PROPERTIES IN COMPARISON WITH THE POLYLACTAM FOAMS OF THE PRIOR ART WHICH MAKE THEM ESPECIALLY USEFUL FOR THE MANUFACTURE OF LOW DENSITY ARTICLES REQUIRING RELATIVELY HIGH STRENGTH AND CHEMICAL RESISTANCE.

公开(公告)号：CA860998A

公开(公告)日：1971-01-12

申请号：CA860998D

Applicant: TORAY INDUSTRIES

Inventor： OKADA HIROSHI ,  TANAKA TAKASHI ,  OSAKADA ATSUSHI ,  WAKAMURA NOBUO

公开(公告)号：AU2003211765B2

公开(公告)日：2007-11-01

申请号：AU2003211765

申请日：2003-03-06

Applicant: NAT INST AGROBIOLOGICAL SCIENCES ,  TORAY INDUSTRIES

Inventor： HIRAMATSU SHINGO ,  YAMADA KATSUSHIGE ,  TANAKA TAKASHI ,  TAMURA TOSHIKI

IPC: C12N15/85 ,  A01K67/033 ,  A01K67/04 ,  C07K14/52

Abstract: Producing (M1) a recombinant protein comprising inserting the gene for the protein placed downstream of a promoter of silkworm origin into the genome of silkworms, the silk threads or cocoons of the silkworms (containing the protein), harvesting and recovering the recombinant protein from the thread or cocoons, is new. Independent claims are also included for (1) transformed silkworms for use in (M1); (2) vectors for introduction of the foreign gene into the silkworm genome; (3) producing the foreign protein by culture of transformed silkworm cells; and (4) silk containing the foreign protein.

公开(公告)号：CA2478205A1

公开(公告)日：2003-09-12

申请号：CA2478205

申请日：2003-03-06

Applicant: TORAY INDUSTRIES ,  NAT INST OF AGROBIO SCIENCES

Inventor： TAMURA TOSHIKI ,  YAMADA KATSUSHIGE ,  TANAKA TAKASHI ,  HIRAMATSU SHINGO

IPC: A01K67/033 ,  A01K67/04 ,  C07K14/52 ,  C12N15/85 ,  C12N15/09 ,  C12P21/02

Abstract: It is intended to provide a genetic engineering material for insects whereby a target protein can be easily purified without resort to a recombinant baculovirus and a process for producing a foreign protein with the use of th is genetic engineering material. A genetically modified silk worm is obtained b y transferring a foreign protein gene (for example, a cytokine gene) ligated t o a promoter functioning in the silk gland into silkworm chromosome. Then the foreign protein (for example, cytokine) is extracted and purified from the silk gland or cocoon of the silkworm or its offspring. By transferring a gen e cassette for expression wherein the 5~-terminal DNA sequence of fibroin H- chain gene is fused with the 3~-terminal DNA sequence of a foreign protein gene into silk gland cells or the like, the foreign protein can be produced in a large amount both inside and outside the silk gland cells as well as in si lk yarn and cocoon.

公开(公告)号：AU2003211765A1

公开(公告)日：2003-09-16

申请号：AU2003211765

申请日：2003-03-06

Applicant: TORAY INDUSTRIES ,  NAT INST OF AGROBIO SCIENCES

Inventor： HIRAMATSU SHINGO ,  TANAKA TAKASHI ,  YAMADA KATSUSHIGE ,  TAMURA TOSHIKI

IPC: A01K67/033 ,  A01K67/04 ,  C07K14/52 ,  C12N15/85 ,  C12N15/09 ,  C12P21/02

Abstract: Producing (M1) a recombinant protein comprising inserting the gene for the protein placed downstream of a promoter of silkworm origin into the genome of silkworms, the silk threads or cocoons of the silkworms (containing the protein), harvesting and recovering the recombinant protein from the thread or cocoons, is new. Independent claims are also included for (1) transformed silkworms for use in (M1); (2) vectors for introduction of the foreign gene into the silkworm genome; (3) producing the foreign protein by culture of transformed silkworm cells; and (4) silk containing the foreign protein.

公开(公告)号：EP1712561A4

公开(公告)日：2008-09-03

申请号：EP05703849

申请日：2005-01-12

Applicant: TORAY INDUSTRIES ,  DU PONT

Inventor： HIRAMATSU SHINGO ,  MORIYAMA HIROMITSU ,  ASAOKA RYOTA ,  MORITA KEN ,  TANAKA TAKASHI ,  YAMADA KATSUSHIGE ,  OBRIEN JOHN PHILIP ,  FAHNESTOCK STEPHEN R

IPC: C07K14/435 ,  A01K67/033 ,  A01K67/04 ,  C12N5/16 ,  C12N15/09 ,  C12N15/85 ,  D01B7/00 ,  D02G3/02

CPC classification number: A01K67/0339 ,  A01K67/04 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/01 ,  C07K14/43518 ,  C12N15/8509 ,  D01B7/00

Abstract: By using a transgenic silkworm having a gene, which encodes a spider thread protein having desired properties (a high strength, a high elongation, etc.), transferred thereinto without injuring silkworm fibroin H-chain gene by a means of, for example, using the transposon function, the spider thread protein having the desired properties is produced by the transgenic silkworm without lowering the strength or elongation of silk thread produced by the transgenic silkworm, thereby providing a hybrid silk of spider thread with silk thread having the desired properties.

公开(公告)号：EP1482035A4

公开(公告)日：2005-11-09

申请号：EP03743628

申请日：2003-03-06

Applicant: TORAY INDUSTRIES ,  NAT INST OF AGROBIO SCIENCES

Inventor： HIRAMATSU SHINGO ,  TANAKA TAKASHI ,  YAMADA KATSUSHIGE ,  TAMURA TOSHIKI

IPC: A01K67/033 ,  A01K67/04 ,  C07K14/52 ,  C12N15/85 ,  C12N15/09 ,  C12P21/02

CPC classification number: C12N15/8509 ,  A01K67/033 ,  A01K67/0335 ,  A01K67/04 ,  A01K2217/05 ,  A01K2267/01 ,  C07K14/52

Abstract: It is intended to provide a genetic engineering material for insects whereby a target protein can be easily purified without resort to a recombinant baculovirus and a process for producing a foreign protein with the use of this genetic engineering material. A genetically modified silk worm is obtained by transferring a foreign protein gene (for example, a cytokine gene) ligated to a promoter functioning in the silk gland into silkworm chromosome. Then the foreign protein (for example, cytokine) is extracted and purified from the silk gland or cocoon of the silkworm or its offspring. By transferring a gene cassette for expression wherein the 5’-terminal DNA sequence of fibroin H-chain gene is fused with the 3’-terminal DNA sequence of a foreign protein gene into silk gland cells or the like, the foreign protein can be produced in a large amount both inside and outside the silk gland cells as well as in silk yarn and cocoon.

公开(公告)号：JP2002101879A

公开(公告)日：2002-04-09

申请号：JP2000299863

申请日：2000-09-29

Applicant: TORAY INDUSTRIES

Inventor： TANAKA TAKASHI ,  OKAMOTO HISAYO ,  YAMADA MASANARI

IPC: C12N15/09 ,  A61K9/08 ,  A61K9/19 ,  A61K38/00 ,  A61K38/21 ,  A61K47/02 ,  A61K47/12 ,  A61K47/18 ,  A61K47/20 ,  A61K47/32 ,  A61K47/36 ,  A61K47/46 ,  A61P31/12 ,  A61P37/02 ,  A61P43/00 ,  C07K14/57 ,  C12P21/02

Abstract: PROBLEM TO BE SOLVED: To provide a composition capable of stably preserving the physiological activity of the useful protein therein, and to provide a method for producing the composition. SOLUTION: This composition is obtained by adding at least two components selected from organic acids and alkali metal salts thereof, compounds having thiol structure and gum arabic, each being nonvolatile even if the composition undergoes a lyophilization treatment, to a useful protein.

公开(公告)号：JPS62167038A

公开(公告)日：1987-07-23

申请号：JP806486

申请日：1986-01-20

Applicant: TORAY INDUSTRIES

Inventor： TANAKA TAKASHI ,  WAKAMURA YOSHIO ,  FURUKO MAMORU

IPC: B32B5/18 ,  B32B9/00

公开(公告)号：JP2004254681A

公开(公告)日：2004-09-16

申请号：JP2003310426

申请日：2003-09-02

Applicant: NAT INST OF AGROBIO SCIENCES ,  TORAY INDUSTRIES

Inventor： TAMURA TOSHIKI ,  YAMADA MASANARI ,  HIRAMATSU SHINGO ,  TANAKA TAKASHI

IPC: A01K67/033 ,  C07K14/435 ,  C07K19/00 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02

Abstract: PROBLEM TO BE SOLVED: To obtain a gene engineering material for easily purifying an objective protein without requiring use of recombinant baculovirus, and provide a method for producing a foreign protein by using the gene engineering material. SOLUTION: A large amount of the foreign protein is produced in silk gland cells, outside of silk gland cells or brought to produce silk by introducing an expression gene cassette prepared by fusing a DNA sequence of 5' terminal and a DNA sequence of 3' terminal of fibroin H chain gene with a foreign protein gene. By the new method, foreign protein easily purified is produced using the silk gland without using the recombinant baclovirus, and a technique for producing the foreign protein is established. COPYRIGHT: (C)2004,JPO&NCIPI