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公开(公告)号：SG11201901514PA
公开(公告)日：2019-03-28
申请号：SG11201901514P
申请日：2017-09-08
Applicant: TORAY INDUSTRIES
Inventor： KANDA SHUNGO , TAKAHASHI HIROSHI , TOMITA NAOTOSHI
Abstract: MATERIAL FOR BLOOD PURIFICATION An object of the present invention is to provide a material for blood purification having the capability to remove cytokines and activated leukocyte-activated platelet complexes. The present invention provides a material for blood purification, the 5 material containing a water-insoluble material in which a ligand having an amide group(s) and an amino group(s) is bound to a substrate, wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material; and wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material. 10 [Fig. 1]
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公开(公告)号：CA3032532A1
公开(公告)日：2018-03-15
申请号：CA3032532
申请日：2017-09-08
Applicant: TORAY INDUSTRIES
Inventor： KANDA SHUNGO , TAKAHASHI HIROSHI , TOMITA NAOTOSHI
Abstract: The purpose of the present invention is to provide a material for blood purification having the ability to remove cytokines and activated leukocyte-activated platelet complexes. The present invention provides a material for blood purification that includes a water-insoluble material in which a ligand having amide groups and amino groups is bonded to a substrate, the amide group content being 3.0-7.0 mmol per gram dry weight of the water-insoluble material and the amino group content being 1.0-7.0 mmol per gram dry weight of the water-insoluble material.
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公开(公告)号：CA2844452A1
公开(公告)日：2013-02-14
申请号：CA2844452
申请日：2012-08-08
Applicant: TORAY INDUSTRIES
Inventor： TOMITA NAOTOSHI , UENO YOSHIYUKI
Abstract: The aim of the present invention is to provide: a highly solvent- and heat-resistant carrier for adsorption that, regardless of the presence of an amide group or the like, has outstanding blood component adsorption properties and in particular inflammatory cytokine adsorption properties; and a method for producing a carrier for adsorption that can introduce a desired functional group onto the surface of a carrier and cross-link groups of aromatic rings in one step. The present invention provides a carrier for adsorption comprising at least one type of polymer compound having at least two repeating units containing aromatic rings. The aromatic rings form covalent bonds via the structure represented in general formula (I). [R1 represents hydrogen or an organic group, and R2 represents an organic group.]
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公开(公告)号：CA2814942A1
公开(公告)日：2012-05-03
申请号：CA2814942
申请日：2011-10-26
Applicant: TORAY INDUSTRIES
Inventor： TOMITA NAOTOSHI , UENO YOSHIYUKI , TANAHASHI KAZUHIRO
Abstract: The purpose of the present invention is to provide a carrier for blood component adsorption which can adsorb and remove leukocytes in the form of granulocytes, monocytes or lymphocytes, and can also adsorb and remove inflammatory cytokines at the same time while minimizing the occurrence of pressure loss in blood circulation. The present invention provides a carrier for blood component adsorption, wherein a functional group containing an acid functionality selected from the group consisting of a sulfate group, a sulfite group and a sulfonate group, and an amino group, is introduced onto the surface of a water-insoluble carrier that is composed of fiber or particles, and the fiber diameter of the fiber or the particle size of the particles is 0.5 to 20 µm.
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公开(公告)号：CA3060197A1
公开(公告)日：2018-12-13
申请号：CA3060197
申请日：2018-06-06
Applicant: TORAY INDUSTRIES
Inventor： TOMITA NAOTOSHI , SHIMADA KAORU , TAKAHASHI HIROSHI
IPC: A61M1/36 , A61K35/14 , A61P11/00 , B01J20/28 , B01J20/281
Abstract: The purpose of the present invention is to provide a material that can very efficiently remove the activated leukocyte-activated platelet complex. The present invention provides a material that removes the activated leukocyte-activated platelet complex, which is a water-insoluble carrier having a surface to which a compound having a charge-bearing functional group is bonded, wherein the profile length ratio of this surface is 4 to 7.
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Patent Agency Ranking
公开(公告)号：ES2659840T3
公开(公告)日：2018-03-19
申请号：ES14804488
申请日：2014-05-30
Applicant: TORAY INDUSTRIES
Inventor： TOMITA NAOTOSHI , SHIMADA KAORU , UENO YOSHIYUKI
Abstract: Columna recubierta con portador de adsorción que es una columna recubierta con portador de adsorción de tipo flujo radial, que comprende: un tubo central en el que uno o varios poros dispuestos para permitir la salida de un líquido suministrado está/están formados en una o varias superficies laterales longitudinales; un portador de adsorción que recubre la circunferencia de dicho tubo central, para permitir la adsorción de una o varias moléculas diana o una o varias células diana contenidas en dicho líquido; una placa A dispuesta para comunicar con el extremo aguas arriba de dicho tubo central, de tal modo que dicho líquido entrante pasa a través de dicho tubo central, estando dicha placa A dispuesta de tal modo que se impide el contacto de dicho líquido con dicho portador de adsorción sin pasar a través de dicho tubo central; y una placa B dispuesta de tal modo que el extremo aguas abajo de dicho tubo central está cerrado de manera estanca y dicho portador de adsorción está inmovilizado en el espacio en la circunferencia de dicho tubo central; en la que está introducido un material de inserción entre dicho portador de adsorción y dicha placa A; está introducido un material de inserción D entre dicho portador de adsorción y dicha placa B; la proporción (C1/E0) de la tasa de deformación de dicho material de inserción C (C1) frente a la tasa de deformación de dicho portador de adsorción (E0) es 1
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公开(公告)号：CA2844452C
公开(公告)日：2016-01-19
申请号：CA2844452
申请日：2012-08-08
Applicant: TORAY INDUSTRIES
Inventor： TOMITA NAOTOSHI , UENO YOSHIYUKI
Abstract: The present invention aims to provide an adsorptive carrier having remarkable blood component-adsorbing capacity, especially inflammatory cytokine-adsorbing capacity irrespective of whether the carrier has an amide group and/or the like, which carrier also has high solvent resistance and heat resistance, and to provide a method for producing an adsorptive carrier, wherein introduction of a desired functional group on the surface of the carrier and cross-linking between aromatic rings can be achieved by a single step. The present invention provides an adsorptive carrier composed of one or more high-molecular-weight compounds each of which comprises two or more aromatic ring-containing repeating units, which aromatic rings are covalently bound to each other via the structure represented by the General Formula (I) below: [Chemical Formula 1] [wherein R1 represents hydrogen or an organic group, and R2 represents an organic group].
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公开(公告)号：SG11201509453PA
公开(公告)日：2015-12-30
申请号：SG11201509453P
申请日：2014-05-30
Applicant: TORAY INDUSTRIES
Inventor： TOMITA NAOTOSHI , SHIMADA KAORU , UENO YOSHIYUKI
IPC: A61M1/36
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公开(公告)号：AU2012293188B2
公开(公告)日：2015-07-02
申请号：AU2012293188
申请日：2012-08-08
Applicant: TORAY INDUSTRIES
Inventor： TOMITA NAOTOSHI , UENO YOSHIYUKI
Abstract: The present invention aims to provide an adsorptive carrier having remarkable blood component-adsorbing capacity, especially inflammatory cytokine-adsorbing capacity irrespective of whether the carrier has an amide group and/or the like, which carrier also has high solvent resistance and heat resistance, and to provide a method for producing an adsorptive carrier, wherein introduction of a desired functional group on the surface of the carrier and cross-linking between aromatic rings can be achieved by a single step. The present invention provides an adsorptive carrier composed of one or more high-molecular-weight compounds each of which comprises two or more aromatic ring-containing repeating units, which aromatic rings are covalently bound to each other via the structure represented by the General Formula (I) below: [wherein R 1 represents hydrogen or an organic group, and R 2 represents an organic group].
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公开(公告)号：AU2012293188A1
公开(公告)日：2014-02-06
申请号：AU2012293188
申请日：2012-08-08
Applicant: TORAY INDUSTRIES
Inventor： TOMITA NAOTOSHI , UENO YOSHIYUKI
Abstract: The aim of the present invention is to provide: a highly solvent- and heat-resistant carrier for adsorption that, regardless of the presence of an amide group or the like, has outstanding blood component adsorption properties and in particular inflammatory cytokine adsorption properties; and a method for producing a carrier for adsorption that can introduce a desired functional group onto the surface of a carrier and cross-link groups of aromatic rings in one step. The present invention provides a carrier for adsorption comprising at least one type of polymer compound having at least two repeating units containing aromatic rings. The aromatic rings form covalent bonds via the structure represented in general formula (I). [R
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