公开(公告)号：JPH067179A

公开(公告)日：1994-01-18

申请号：JP16740492

申请日：1992-06-25

Applicant: TORAY INDUSTRIES

Inventor： MIYATA REIKO ,  YONEHARA TORU

IPC: C12P7/42 ,  C12R1/01 ,  C12R1/05 ,  C12R1/06 ,  C12R1/13 ,  C12R1/15 ,  C12R1/265 ,  C12R1/365 ,  C12R1/465 ,  C12R1/645 ,  C12R1/72 ,  C12R1/78 ,  C12R1/84 ,  C12R1/85 ,  C12R1/88

Abstract: PURPOSE:To directly produce the subject compound useful as an optical resolution agent or a raw material for penicillin antibiotics, etc., from benzoylformic acid without using complicate operations by using a specific microorganism and taking advantage of the reducing power of the microorganism. CONSTITUTION:Benzoylformic acid is treated with cultured product, microbial cell, etc., of a microorganism capable of converting benzoylformic acid to optically active mandelic acid and belonging to the genus Apiotrichum, Candida, Torulopsis, Rhodotorula, Trichosporon, Rhodosporidium, Pichia, Kloechera, Hansenula, Saccharomyces, Klebsiella, Rhodococcus, Microbacterium, Brevibacterium, Corynebacterium, Arthrobacter, Enterobacter, Micrococcus, Alcaligenes, Amycolatopsis, Streptomyces or Nocardioides and the objective compound is separated from the reaction liquid.

公开(公告)号：JPH05186303A

公开(公告)日：1993-07-27

申请号：JP17496291

申请日：1991-07-16

Applicant: SANKYO CO ,  TORAY INDUSTRIES

Inventor： AMAGASA TADASHI ,  OGAWA MASAMI ,  KAMURO YASUO ,  YONEHARA TORU

IPC: A01N37/42

Abstract: PURPOSE:To obtain a new flower blooming promoter capable of replacing low temperature treatment to plants or capable of further enhancing low temperature effect and giving no influence other than flower blooming on plants. CONSTITUTION:The objective flower blooming promoter contains a natural type abscisic acid as an active ingredient. Flower budding, flower stalk development and blooming (jarovization) of wheat, vegetables, bulbs and flowers at low temperature are promoted by treating seeds, bulbs or plant bodies with the natural type abscisic acid.

公开(公告)号：JPH0558803A

公开(公告)日：1993-03-09

申请号：JP3930792

申请日：1992-02-26

Applicant: TORAY INDUSTRIES

Inventor： KAMURO YASUO ,  YONEHARA TORU

IPC: A01N3/02

Abstract: PURPOSE:To obtain a water-soluble, colorless, transparent and odorless preserving agent for cut flower of carnation having excellent freshness retaining effect and freshness prolonging effect, capable of readily treating and harmless to a number of plants, human beings and beasts. CONSTITUTION:A preserving agent for cut flower of carnation containing (+)-2- cis-4-trans-abscisic acid (natural type abscisic acid) extracted and purified from culture mixture of a plant or a microorganism, preferably microorganism belonging to Botrytis cinerea as an active ingredient. The concentration of this agent to be used is 0.01-100ppm, pred., 0.05-10ppm as the active ingredient. Withering of the cut flower of carnation is prevented and it is made possible to enjoy the flower for a long period by using this preserving agent. The above-mentioned active ingredient can safely be used because the ingredient is originally a natural hormone widely contained in plants. The ingredient can provide good preserving effect in a state where the cut flower is inserted and the treatment is simple, because it is not required to restrict absorbing time of the drug.

公开(公告)号：JPH0558802A

公开(公告)日：1993-03-09

申请号：JP3929692

申请日：1992-02-26

Applicant: TORAY INDUSTRIES

Inventor： KAMURO YASUO ,  YONEHARA TORU

IPC: A01N3/02

Abstract: PURPOSE:To obtain a water-soluble, colorless, transparent and odorless preserv ing agent for cut flower of chrysanthemum, having excellent freshness retaining effect and freshness prolonging effect, capable of readily treating and harmless to a number of plants, human being and beasts. CONSTITUTION:A preserving agent for cut flower of chrysanthemum containing (+)-2-cis-4-trans-abscisic acid (natural type abscisic acid) extracted and purified from culture mixture of a plant or a microorganism, preferably microorganism belonging to Botrytis cinerea as an active ingredient. The concentration of this agent to be used is 0.01-100ppm, pref., 0.05-10ppm as the active ingredient. Withering of the cut flower of chrysanthemum is prevented and it is made possible to enjoy the flower for a long period by using this preserving agent. The above-mentioned active ingredient can safely be used because the ingredient is originally a natural hormone widely contained in plants. The ingredient can provide good preserving effect in a state where the cut flower is inserted and the treatment is simple because it is not required to restrict absorbing time of the drug.

公开(公告)号：JPH03112490A

公开(公告)日：1991-05-14

申请号：JP24883689

申请日：1989-09-25

Applicant: TORAY INDUSTRIES

Inventor： FUJIKAWA KAZUHIRO ,  SATOU HARUYO ,  YONEHARA TORU ,  MIYATA AKIRA

IPC: C12P13/22 ,  C12R1/01 ,  C12R1/06 ,  C12R1/13 ,  C12R1/15 ,  C12R1/19

Abstract: PURPOSE:To produce L-homophenylalanine useful as a raw material for a precursor of ACE inhibitor, having high optical purity, efficiently and inexpensively by treating benzylpyruvic acid with a culture mixture or cells of bacterium having specific action. CONSTITUTION:Benzylpyruvic acid (substrate concentration: about 0.1-5%) is treated with a culture mixture of a bacterium such as Corynebacterium glutamicum ATCC 13032 belonging to at least one of Corynebacterium, Brevibacterium, Bacillus, Microbacterium, Citrobacter, Arthrobacter and Escherichia, capable of converting benzylpyruvic acid into L-homophenylalanine or cells or treated material thereof at 20-40 deg.C, preferably 25-35 deg.C at pH7.5-9.0 and L-homophenylalanine is isolated from the reaction solution and collected.

公开(公告)号：JPH02171194A

公开(公告)日：1990-07-02

申请号：JP32449588

申请日：1988-12-21

Applicant: TORAY INDUSTRIES

Inventor： TAKEUCHI MASAE ,  YONEHARA TORU

IPC: C12P13/06 ,  C12N1/20 ,  C12R1/15

Abstract: PURPOSE:To inexpensively and simply obtain the title compound useful as a synthetic raw material, etc., for peptide without requiring operation of optical resolution by culturing a microorganism of the genus Corynebacterium having D-alanine-producing ability and specific resistance. CONSTITUTION:A microorganism [e.g. Corynebacterium glutamicum DCSR-13 (FERM P-10435)] of the genus Corynebacterium having D-alanine producing ability and resistance to D-cycloserine is cultured and the aimed compound produced and accumulated in a culture medium is collected. Furthermore, the culture is preferably carried out under aerobic conditions at nearly 30 deg.C and nearly neutral pH for several times.

公开(公告)号：JPS63258586A

公开(公告)日：1988-10-26

申请号：JP9093987

申请日：1987-04-15

Applicant: TORAY INDUSTRIES

Inventor： MIYATA REIKO ,  YONEHARA TORU ,  YOMOTO KYOSUKE

IPC: C12P7/40 ,  C12R1/88

Abstract: PURPOSE:To produce pyruvic acid in high efficiency, by preparing a variant having lowered PDC activity from a microorganism capable of producing pyruvic acid and belonging to Torulopsis genus and culturing the variant in a medium. CONSTITUTION:Cell of Torulopsis glabrate IFO 0005 is treated with ethylmethane sulfonate to obtain a variant having PDC (pyruvate decarboxylase) activity lowered to

公开(公告)号：JPS62201593A

公开(公告)日：1987-09-05

申请号：JP4258286

申请日：1986-02-27

Applicant: TORAY INDUSTRIES

Inventor： MORI CHIZUKO ,  YONEHARA TORU ,  YOMOTO KYOSUKE

IPC: C12P13/22 ,  C12R1/01

Abstract: PURPOSE:To obtain L-tryptophan useful as pharmaceutical or feed additive, economically on an industrial scale, by culturing a microbial strain belonging to Providencia genus and capable of producing L-tryptophan. CONSTITUTION:A microbial strain belonging to Providencia genus and capable of producing L-tryptophan, e.g. Providencia rettgeri 5-FT(R)-11 (FERM P-8659) is cultured in a proper medium preferably under shaking or aeration preferably at 5-9 pH and 24-37 deg.C usually for 48-120hr. The produced L-tryptophan is separated from the culture liquid e.g. by passing the culture liquid through a strongly acidic cation exchange resin optionally after removing the microbial cells from the liquid.

公开(公告)号：JP2000078996A

公开(公告)日：2000-03-21

申请号：JP19008599

申请日：1999-07-05

Applicant: TORAY INDUSTRIES

Inventor： MIYATA REIKO ,  IGARASHI KOJI ,  YONEHARA TORU

IPC: C12P7/50

Abstract: PROBLEM TO BE SOLVED: To inexpensively produce pyruvic acid of a synthetic raw material important for various kind of medicines and agrochemicals and the like in a high yield by using microorganisms having resistance to a high concentration pyruvic acid and a halogenated pyruvic acid, and further having ability for producing the pyruvic acid. SOLUTION: Microoganisms having resistance to a high concentration pyruvic acid and/or a halogenated pyruvic acid, further having ability for producing the pyruvic acid, and belonging to the genus Torulopsis [e.g. Torulopsis glabrata P120-5a (FERM P-16745)] or genus Candida [e.g. Candida methanolovescens B35 (FERM P-17429)] are cultured to accumulate the pyruvic acid in the cultured liquid. The objective pyruvic acid is economically produced in high yield by gathering the pyruvic acid from the cultured liquid. The pyruvic acid is an intermediate important for metabolism of an organism, and a synthetic raw material important for various kinds of medicines and agrochemicals, and the need is in expanding state.

公开(公告)号：JPH09121881A

公开(公告)日：1997-05-13

申请号：JP22272196

申请日：1996-08-23

Applicant: TORAY INDUSTRIES

Inventor： MIYATA REIKO ,  YONEHARA TORU

IPC: C12P17/18 ,  C07D475/04 ,  C12N1/38 ,  C12R1/01 ,  C12R1/07 ,  C12R1/13 ,  C12R1/645 ,  C12R1/72 ,  C12R1/85

Abstract: PROBLEM TO BE SOLVED: To efficiently obtain folic acid useful as a medicine, a raw material for medicines, a reinforcing agent for modified milk powder, a feed additive, an additive for culturing microorganisms, etc., by culturing a microorganism having an ability to produce the folic acid in the presence of a para- aminobenzoic acid derivative. SOLUTION: In this method for producing folic acid with a microorganism, the microorganism belonging to the genus Bacillus, Brevibacterium, Rhodococcus, Torulopsis, Saccharomyces, Pichia, Candida, etc., is cultured in the presence of a para-aminobenzoate such as a para-aminobenzoate alkali metal salt or a lower alkyl para-aminobenzoate. Thus, the folic acid useful as a medicine, a raw material for medicines, a reinforcing agent for modified milk powder, a feed additive, an additive for culturing microorganisms, etc., is effectively obtained.