公开(公告)号：US11780882B2

公开(公告)日：2023-10-10

申请号：US17239544

申请日：2021-04-23

Applicant: TRANSFERT PLUS, S.E.C.

Inventor： Richard Béliveau ,  Borhane Annabi ,  Michel Demeule ,  Alain Larocque ,  Jean-Christophe Currie ,  Cyndia Charfi

IPC: C07K7/08 ,  A61K47/64 ,  A61P35/00 ,  A61K31/337 ,  C07K1/06 ,  C07K14/00 ,  A61K38/00

CPC classification number: C07K7/08 ,  A61K31/337 ,  A61K47/64 ,  A61P35/00 ,  C07K1/061 ,  C07K14/001 ,  A61K38/00

Abstract: The present disclosure relates to peptide compounds and conjugate compounds, processes, methods and uses thereof for treating cancer. For example, the compounds can comprise compounds of formula













X1X2X3X4X5GVX6AKAGVX7NX8FKSESY
(SEQ ID NO: 1)


(I)






(X9)nGVX10AKAGVX11NX12FKSESY
(SEQ ID NO: 2)


(II)






YKX13LRRX14APRWDX15PLRDPALRX16X17L
(SEQ ID NO: 3)


(III)






YKX18LRR(X19)nPLRDPALRX20X21L
(SEQ ID NO: 4)


(IV)






IKLSGGVQAKAGVINMDKSESM
(SEQ ID NO: 5)


(V)






IKLSGGVQAKAGVINMFKSESY
(SEQ ID NO: 6)


(VI)






IKLSGGVQAKAGVINMFKSESYK
(SEQ ID NO: 7)


(VII)






GVQAKAGVINMFKSESY
(SEQ ID NO: 8)


(VIII)






GVRAKAGVRNMFKSESY
(SEQ ID NO: 9)


(IX)






GVRAKAGVRN(Nle)FKSESY
(SEQ ID NO: 10)


(X)






YKSLRRKAPRWDAPLRDPALRQLL
(SEQ ID NO: 11)


(XI)






YKSLRRKAPRWDAYLRDPALRQLL
(SEQ ID NO: 12)


(XII)






YKSLRRKAPRWDAYLRDPALRPLL
(SEQ ID NO: 13)


(XIII)











wherein X1 to X21 and n can have various different values
and wherein at least one protecting group and/or at least one labelling agent is optionally connected to said peptide compound at an N- and/or C-terminal end.

公开(公告)号：US12269902B2

公开(公告)日：2025-04-08

申请号：US18240295

申请日：2023-08-30

Applicant: TRANSFERT PLUS, S.E.C.

Inventor： Richard Béliveau ,  Borhane Annabi ,  Michel Demeule ,  Alain Larocque ,  Jean-Christophe Currie ,  Cyndia Charfi

IPC: C07K7/08 ,  A61K31/337 ,  A61K38/00 ,  A61K47/64 ,  A61P35/00 ,  C07K1/06 ,  C07K14/00

Abstract: The present disclosure relates to peptide compounds and conjugate compounds, processes, methods and uses thereof for treating cancer. For example, the compounds can comprise compounds of formula (SEQ ID NO: 1) X1X2X3X4X5GVX6AKAGVX7NX8FKSESY (I) (SEQ ID NO: 2) (X9)nGVX10AKAGVX11NX12FKSESY (II) (SEQ ID NO: 3) YKX13LRRX14APRWDX15PLRDPALRX16X17L (III) (SEQ ID NO: 4) YKX18LRR(X19)nPLRDPALRX20X21L (IV) (SEQ ID NO: 5) IKLSGGVQAKAGVINMDKSESM (V) (SEQ ID NO: 6) IKLSGGVQAKAGVINMFKSESY (VI) (SEQ ID NO: 7) IKLSGGVQAKAGVINMFKSESYK (VII) (SEQ ID NO: 8) GVQAKAGVINMFKSESY (VIII) (SEQ ID NO: 9) GVRAKAGVRNMFKSESY (IX) (SEQ ID NO: 10) GVRAKAGVRN(Nle)FKSESY (X) (SEQ ID NO: 11) YKSLRRKAPRWDAPLRDPALRQLL (XI) (SEQ ID NO: 12) YKSLRRKAPRWDAYLRDPALRQLL (XII) (SEQ ID NO: 13) YKSLRRKAPRWDAYLRDPALRPLL (XIII) wherein X1 to X21 and n can have various different values and wherein at least one protecting group and/or at least one labelling agent is optionally connected to said peptide compound at an N- and/or C-terminal end.

公开(公告)号：US11034727B2

公开(公告)日：2021-06-15

申请号：US15778626

申请日：2016-11-24

Applicant: TRANSFERT PLUS, S.E.C.

Inventor： Richard Béliveau ,  Borhane Annabi ,  Michel Demeule ,  Alain Larocque ,  Jean-Christophe Currie ,  Cyndia Charfi

IPC: C07K7/08 ,  A61K47/64 ,  A61P35/00 ,  A61K31/337 ,  C07K1/06 ,  C07K14/00 ,  A61K38/00

Abstract: The present disclosure relates to peptide compounds and conjugate compounds, processes, methods and uses thereof for treating cancer and increasing cellular internalization of said peptide compounds. The peptide compounds are selected from the following group consisting of; GVRAKAGVRNMFKSESY as set forth in SEQ ID NO: 9; GVRAKAGVRN(Nle)FKSESY as set forth in SEQ ID NO: 10; and YKSLRRKAPRWDAPLRDPALRQLL as set forth in SEQ ID NO: 11; and wherein at least one protecting group and/or at least one labelling agent is connected to said peptide compound.