SELF-ENCODING SENSOR WITH MICROSPHERES

    公开(公告)号:CA2366018A1

    公开(公告)日:2000-10-12

    申请号:CA2366018

    申请日:2000-04-06

    Applicant: TUFTS COLLEGE

    Abstract: A microsphere-based analytic chemistry system is disclosed in which self- encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the abili ty is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using a n optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

    Combinatorial polymer synthesis of sensors for polymer-based sensor arrays

    公开(公告)号:AU6131299A

    公开(公告)日:2000-03-21

    申请号:AU6131299

    申请日:1999-08-26

    Applicant: TUFTS COLLEGE

    Abstract: A combinatorial synthesis method for fabricating unique families of discrete copolymer sensors and copolymer gradient sensors is provided. The method employs combinatorial copolymer synthesis of discrete monomer or oligomer combinations as well as spatially-varying combinations for generating large numbers of analyte-discriminating sensors from a limited selection of initial monomer and oligomer compositions. The method can be applied to either analyte-specific sensors or sensor arrays or semi-selective sensors and cross-reactive sensor arrays which employ virtually any known physicochemical transduction mechanism for detecting analytes. Since the analyte response characteristics of such copolymer sensors are not limited to a linear proportional ratio of the monomer or oligomer combinations employed, the resulting copolymer sensors provide for increased diversity in sensor and sensor array response characteristics for discriminating between a variety of materials and for detecting and identifying analytes in fluid samples.

    Self-encoding fiber optic sensor
    7.
    发明专利

    公开(公告)号:AU755141B2

    公开(公告)日:2002-12-05

    申请号:AU1269599

    申请日:1998-10-06

    Applicant: TUFTS COLLEGE

    Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response and signal-to-noise ratios.

    ΑΥΤΟΚΩΔΙΚΟΠΟΙΟΥΜΕΝΟΣ ΑΙΣΘΗΤΗΡΑΣ ΜΕ ΜΙΚΡΟΣΦΑΙΡΕΣ

    公开(公告)号:CY1120302T1

    公开(公告)日:2019-07-10

    申请号:CY181100593

    申请日:2018-06-06

    Applicant: TUFTS COLLEGE

    Abstract: Κοινοποιείταισύστημααναλυτικήςχημείαςπουβασίζεταισεμικροσφαίρεςστοοποίοοιαυτοκωδικοποιούμενεςμικροσφαίρες, πουέχουνδιακριτέςχαρακτηριστικέςυπογραφέςοπτικήςαπόκρισηςσεσυγκεκριμένουςαναλυτέςστόχου, μπορούννααναμιχθούνμαζίενώδιατηρείταιη ικανότηταγιααναγνώρισητουτύπουαισθητήρακαιτηςθέσηςκάθεαισθητήρα, σεμιατυχαίαδιασποράμεγάλωναριθμώντέτοιωναισθητήρωνσεμιαδιάταξηαισθητήρων, χρησιμοποιώνταςένασχέδιοκωδικοποίησηςμεδυνατότηταοπτικήςανάκρισης. Κοινοποιείταιεπίσηςαισθητήραςδέσμηςοπτικώνινώνστονοποίομεμονωμένοιαισθητήρεςμικροσφαιρώνδιατίθενταισεμικροφρεάτιασεέναμακρινόάκροτηςδέσμηςινώνκαισυζευγνύονταιοπτικάμεδιακριτέςίνεςή ομάδεςινώνμέσαστηδέσμη. Οιταυτότητεςτωνμεμονωμένωναισθητήρωνστηδιάταξηαυτοκωδικοποιούνταιμετηνέκθεσητηςδιάταξηςσεέναναναλυτήαναφοράςφωτίζονταςταυτόχρονατηδιάταξημεενέργειαφωτόςδιέγερσης. Μιαμοναδικήδιάταξηαισθητήρωνμπορείναφέρειχιλιάδεςδιακριτώνστοιχείωναίσθησηςτωνοποίωντοσυνδυασμένοσήμαπαρέχεισημαντικέςβελτιώσειςσταόριαανίχνευσηςαισθητήρα, στουςχρόνουςαπόκρισηςκαιστουςλόγουςσήματοςπροςθόρυβο.

    Sensor de autocodificación con microesferas

    公开(公告)号:ES2668960T3

    公开(公告)日:2018-05-23

    申请号:ES07023438

    申请日:2000-04-06

    Applicant: TUFTS COLLEGE

    Abstract: Un método para analizar datos de señal obtenidos a partir de una matriz para la unión de un analito diana, comprendiendo dicho método: a) proporcionar una matriz que comprende una primera subpoblación y una segunda subpoblación de cuentas distribuidas sobre una superficie de un sustrato, comprendiendo dichas cuentas sondas de ácido nucleico, en donde las cuentas en dicha primera subpoblación son diferentes de las cuentas en dicha segunda subpoblación y en donde cada una de la primera y la segunda subpoblaciones comprende una pluralidad de cuentas que comprenden sondas de ácido nucleico idénticas; b) proporcionar a dicha matriz un analito diana, en donde dicho analito diana es un ácido nucleico y se une a la primera subpoblación de elementos sensores y/o a la segunda población de elementos sensores; c) obtener señales de respuestas ópticas de una pluralidad de cuentas dentro de dicha primera subpoblación y/o dentro de dicha segunda subpoblación; y d) analizar estadísticamente las señales de respuesta obtenidas a partir de dicha primera subpoblación de cuentas y/o de dicha segunda subpoblación de cuentas, para hacer una estimación cuantitativa de la confianza acerca de los datos.

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