公开(公告)号：US20150185151A1

公开(公告)日：2015-07-02

申请号：US14415311

申请日：2013-07-16

Applicant: The Arizona Board of Regents on behalf of the University of Arizona

Inventor： Urs Utzinger ,  Bhaskar Banerjee ,  Timothy E. Renkoski ,  Nathaniel S. Rial ,  Logan Graves

IPC: G01N21/64 ,  G01N33/483 ,  G01N21/55

CPC classification number: G01N21/6486 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  G01N21/4795 ,  G01N21/55 ,  G01N21/6456 ,  G01N21/6458 ,  G01N33/4833 ,  G01N2021/6484 ,  G01N2201/0686

Abstract: Methods for reliable identification of low-contrast lesions within a tissue of a subject comprise delivering an excitation signal to the tissue, wherein the excitation signal is selected to stimulate tissue to produce autofluorescence and/or reflectance. The autofluorescence and/or reflectance is detected, and ratiometric images are produced based on the autofluorescence and/or reflectance images. An imaging system is provided which is configured to carry out such methods, irradiating tissue at a various possible excitation wavelengths, such as UV excitation wavelengths below 300 nm, to elicit fluorescence from specific native fluorophores.

Abstract translation: 用于可靠地鉴定受试者组织内的低对比度损伤的方法包括向组织递送激发信号，其中选择激发信号以刺激组织以产生自发荧光和/或反射。 检测自发荧光和/或反射率，并且基于自发荧光和/或反射图像产生比例图像。 提供了一种成像系统，其被配置为执行这样的方法，以各种可能的激发波长照射组织，例如低于300nm的UV激发波长，以引发特定天然荧光团的荧光。

公开(公告)号：US09952157B2

公开(公告)日：2018-04-24

申请号：US14415311

申请日：2013-07-16

Applicant: The Arizona Board of Regents on behalf of the University of Arizona

Inventor： Urs Utzinger ,  Bhaskar Banerjee ,  Timothy E. Renkoski ,  Nathaniel S. Rial ,  Logan Graves

IPC: G01N21/00 ,  G01N21/64 ,  A61B1/00 ,  G01N21/47 ,  G01N21/55 ,  G01N33/483 ,  A61B1/04

CPC classification number: G01N21/6486 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  G01N21/4795 ,  G01N21/55 ,  G01N21/6456 ,  G01N21/6458 ,  G01N33/4833 ,  G01N2021/6484 ,  G01N2201/0686

Abstract: Methods for reliable identification of low-contrast lesions within a tissue of a subject comprise delivering an excitation signal to the tissue, wherein the excitation signal is selected to stimulate tissue to produce autofluorescence and/or reflectance. The autofluorescence and/or reflectance is detected, and ratiometric images are produced based on the autofluorescence and/or reflectance images. An imaging system is provided which is configured to carry out such methods, irradiating tissue at a various possible excitation wavelengths, such as UV excitation wavelengths below 300 nm, to elicit fluorescence from specific native fluorophores.