公开(公告)号：PT934928E

公开(公告)日：2004-12-31

申请号：PT97937814

申请日：1997-08-28

Applicant: SANKYO CO ,  UBE INDUSTRIES

Inventor： KOIKE HIROYUKI ,  SUGIDACHI ATSUHIRO ,  ASAI FUMITOSHI ,  IKEDA TOSHIHIKO ,  INOUE TERUHIKO ,  TAKATA KATSUNORI ,  IWAMURA RYO ,  KITA JUN-ICHIRO ,  YONEDA KEMJI

IPC: A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/46 ,  A61P7/02 ,  A61P9/10 ,  C07D205/04 ,  C07D205/08 ,  C07D207/08 ,  C07D207/12 ,  C07D211/20 ,  C07D211/54 ,  C07D211/72 ,  C07D213/70 ,  C07D451/02 ,  C07D451/04

Abstract: Cyclic amine compounds of formula R1-R2CH-R3 (I) are new. R1 = phenyl optionally substituted by 1-4C alkyl, halo, fluoro-substituted 1-4C alkyl, 1-4C alkoxy, fluoro-substituted 1-4C alkoxy, cyano or nitro; R2 = 1-8C aliphatic acyl optionally substituted by halo, OH, 1-4C alkoxy or cyano; benzoyl optionally substituted by 1-4C alkyl, halo or 1-4C alkoxy; or (1-4C alkoxy)carbonyl; R3 = optionally condensed 3-7 membered cyclic saturated amino group substituted by optionally protected mercapto or 1-4C alkyl optionally substituted by optionally protected mercapto; CR4R5 (mercapto-protecting groups are 1-20C alkanoyl, 3-20C alkenoyl, benzoyl optionally substituted by 1-4C alkyl, halogen or 1-4C alkoxy); or (1-4C alkoxy)carbonyl; and R4, R5 = H, 1-4C alkyl, carboxy, (1-4C alkoxy) carbonyl, carbamoyl or mono- or di-(1-4C alkyl)carbamoyl.

公开(公告)号：DK0934928T3

公开(公告)日：2004-11-08

申请号：DK97937814

申请日：1997-08-28

Applicant: SANKYO CO ,  UBE INDUSTRIES

Inventor： ASAI FUMITOSHI ,  SUGIDACHI ATSUHIRO ,  IKEDA TOSHIHIKO ,  KOIKE HIROYUKI ,  INOUE TERUHIKO ,  TAKATA KATSUNORI ,  IWAMURA RYO ,  KITA JUN-ICHIRO ,  YONEDA KENJI

IPC: A61K31/395 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/20 ,  C07D211/54 ,  C07D211/72 ,  C07D451/04

公开(公告)号：AU7890698A

公开(公告)日：1998-07-31

申请号：AU7890698

申请日：1997-12-25

Applicant: UBE INDUSTRIES

Inventor： KITA JUN-ICHIRO ,  YAMADA SHIN-ICHI ,  OZAKI AUHIKO ,  YOSHIOKA RYUZO ,  TAKAMURA SHINJI ,  FUJIWARA HIROSHI

IPC: C07D401/12 ,  A61K31/445

Abstract: The present invention is to provide a benzenesulfonic acid salt and a benzoic acid salt of (S)-4-Ä4-Ä(4-chlorophenyl)(2-pyridyl)methoxyÜpiperidinoÜbutanoic acid represented by the formula (I): wherein * represents an asymmetric carbon, which are excellent in antihistaminic activity and anti-allergic activity, and a process for producing the same.

公开(公告)号：CA2263983C

公开(公告)日：2006-03-21

申请号：CA2263983

申请日：1997-08-28

Applicant: SANKYO CO ,  UBE INDUSTRIES

Inventor： SUGIDACHI ATSUHIRO ,  IWAMURA RYO ,  ASAI FUMITOSHI ,  TAKATA KATSUNORI ,  IKEDA TOSHIHIKO ,  INOUE TERUHIKO ,  KOIKE HIROYUKI ,  YONEDA KENJI ,  KITA JUN-ICHIRO

IPC: C07D211/72 ,  A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/46 ,  A61P7/02 ,  A61P9/10 ,  C07D205/04 ,  C07D205/08 ,  C07D207/08 ,  C07D207/12 ,  C07D211/20 ,  C07D211/54 ,  C07D213/70 ,  C07D451/02 ,  C07D451/04

Abstract: Cyclic amine derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, excellent in the effect of inhibiting platelet aggregation and useful as a preventive or remedy for embolism, thrombosis or arteriosclerosis, wherein R1 represents optionally substituted phenyl; R2 represents optionally substituted C1 -C8 acyl, optionally substituted benzoyl or C1 -C4 alkoxycarbonyl; and R3 represents optionally fused, substituted three- to seven-membered cyclic saturated amino.

公开(公告)号：PT949260E

公开(公告)日：2002-09-30

申请号：PT97949235

申请日：1997-12-25

Applicant: TANABE SEIYAKU CO ,  UBE INDUSTRIES

Inventor： FUJIWARA HIROSHI ,  KITA JUN-ICHIRO ,  TAKAMURA SHINJI ,  YOSHIOKA RYUZO ,  OZAKI YASUHIKO ,  YAMADA SHIN-ICHI

IPC: C07D401/12

Abstract: The present invention is to provide a benzenesulfonic acid salt and a benzoic acid salt of (S)-4-Ä4-Ä(4-chlorophenyl)(2-pyridyl)methoxyÜpiperidinoÜbutanoic acid represented by the formula (I): wherein * represents an asymmetric carbon, which are excellent in antihistaminic activity and anti-allergic activity, and a process for producing the same.

公开(公告)号：DK0949260T3

公开(公告)日：2002-09-09

申请号：DK97949235

申请日：1997-12-25

Applicant: UBE INDUSTRIES ,  TANABE SEIYAKU CO

Inventor： KITA JUN-ICHIRO ,  FUJIWARA HIROSHI ,  TAKAMURA SHINJI ,  YOSHIOKA RYUZO ,  YAMADA SHIN-ICHI ,  OZAKI YASUHIKO

IPC: C07D401/12

Abstract: The present invention is to provide a benzenesulfonic acid salt and a benzoic acid salt of (S)-4-Ä4-Ä(4-chlorophenyl)(2-pyridyl)methoxyÜpiperidinoÜbutanoic acid represented by the formula (I): wherein * represents an asymmetric carbon, which are excellent in antihistaminic activity and anti-allergic activity, and a process for producing the same.

公开(公告)号：ID21985A

公开(公告)日：1999-08-19

申请号：ID990748

申请日：1997-12-25

Applicant: UBE INDUSTRIES ,  TANABE SEIYAKU CO

Inventor： KITA JUN-ICHIRO ,  FUJIWARA HIROSHI ,  TAKAMURA SHINJI ,  YOSHIOKA RYUZO ,  OZAKI YASUHIKO ,  YAMADA SHIN-ICHI

IPC: C07D401/12

Abstract: The present invention is to provide a benzenesulfonic acid salt and a benzoic acid salt of (S)-4-Ä4-Ä(4-chlorophenyl)(2-pyridyl)methoxyÜpiperidinoÜbutanoic acid represented by the formula (I): wherein * represents an asymmetric carbon, which are excellent in antihistaminic activity and anti-allergic activity, and a process for producing the same.

公开(公告)号：CZ9900630A3

公开(公告)日：1999-07-14

申请号：CZ63099

申请日：1997-08-28

Applicant: SANKYO CO ,  UBE INDUSTRIES

Inventor： ASAI FUMITOSHI ,  SUGIDACHI ATSUHIRO ,  IKEDA TOSHIHIKO ,  KOIKE HIROYUKI ,  INOUE TERUHIKO ,  TAKATA KATSUNORI ,  IWAMURA RYO ,  KITA JUN-ICHIRO ,  YONEDA KENJI

IPC: A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/46 ,  A61P7/02 ,  A61P9/10 ,  C07D205/04 ,  C07D205/08 ,  C07D207/08 ,  C07D207/12 ,  C07D211/20 ,  C07D211/54 ,  C07D211/72 ,  C07D213/70 ,  C07D451/02 ,  C07D451/04

CPC classification number: C07D213/70 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/20 ,  C07D211/54 ,  C07D451/02 ,  C07D451/04 ,  Y02P20/55

公开(公告)号：HU228082B1

公开(公告)日：2012-10-29

申请号：HU9903762

申请日：1997-08-28

Applicant: DAIICHI SANKYO COMPANY ,  UBE INDUSTRIES

Inventor： ASAI FUMITOSHI ,  IKEDA TOSHIHIKO ,  INOUE TERUHIKO ,  IWAMURA RYO ,  KITA JUN-ICHIRO ,  KOIKE HIROYUKI ,  SUGIDACHI ATSUHIRO ,  TAKATA KATSUNORI ,  YONEDA KENJI

IPC: C07D205/04 ,  A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/46 ,  A61P7/02 ,  A61P9/10 ,  C07D205/08 ,  C07D207/08 ,  C07D207/12 ,  C07D211/20 ,  C07D211/54 ,  C07D211/72 ,  C07D213/70 ,  C07D451/02 ,  C07D451/04

Abstract: Cyclic amine compounds of formula R1-R2CH-R3 (I) are new. R1 = phenyl optionally substituted by 1-4C alkyl, halo, fluoro-substituted 1-4C alkyl, 1-4C alkoxy, fluoro-substituted 1-4C alkoxy, cyano or nitro; R2 = 1-8C aliphatic acyl optionally substituted by halo, OH, 1-4C alkoxy or cyano; benzoyl optionally substituted by 1-4C alkyl, halo or 1-4C alkoxy; or (1-4C alkoxy)carbonyl; R3 = optionally condensed 3-7 membered cyclic saturated amino group substituted by optionally protected mercapto or 1-4C alkyl optionally substituted by optionally protected mercapto; CR4R5 (mercapto-protecting groups are 1-20C alkanoyl, 3-20C alkenoyl, benzoyl optionally substituted by 1-4C alkyl, halogen or 1-4C alkoxy); or (1-4C alkoxy)carbonyl; and R4, R5 = H, 1-4C alkyl, carboxy, (1-4C alkoxy) carbonyl, carbamoyl or mono- or di-(1-4C alkyl)carbamoyl.

公开(公告)号：NZ334389A

公开(公告)日：2001-05-25

申请号：NZ33438997

申请日：1997-07-28

Applicant: UBE INDUSTRIES ,  SANKYO CO

Inventor： ASAI FUMITOSHI ,  SUGIDACHI ATSUHIRO ,  IKEDA TOSHIHIKO ,  KOIKE HIROYUKI ,  INOUE TERUHIKO ,  TAKATA KATSUNORI ,  IWAMURA RYO ,  KITA JUN-ICHIRO ,  YONEDA KENJI

IPC: A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/46 ,  A61P7/02 ,  A61P9/10 ,  C07D205/04 ,  C07D205/08 ,  C07D207/08 ,  C07D207/12 ,  C07D211/20 ,  C07D211/54 ,  C07D211/72 ,  C07D213/70 ,  C07D451/02 ,  C07D451/04 ,  C07D207/10 ,  C07D207/14 ,  C07D207/36 ,  C07D211/24 ,  C07D211/36 ,  C07D211/68

Abstract: Provided are compounds of the formula R1-C(R2)-R3 wherein: R1 is an optionally substituted phenyl; R2 is an optionally substituted aliphatic acyl or benzoyl group, or an alkoxycarbonyl group; and R3 is a substituted 3 to 7 membered saturated cyclic amino group, which may be in the form of a fused ring; and salts thereof. These compound are reported to possess platelet aggregation inhibitory action and arteriosclerosis progress inhibitory action.