中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

47 records (took 0.026 seconds)

    OBTAINING AN IMPROVED THERAPEUTIC LIGAND
    2.
    发明申请
    OBTAINING AN IMPROVED THERAPEUTIC LIGAND 审中-公开
    获得改进的治疗配偶

    公开(公告)号：WO2014198951A3

    公开(公告)日：2015-08-27

    申请号：PCT/EP2014062478

    申请日：2014-06-13

    Applicant: UCB BIOPHARMA SPRL

    Inventor： SHI JIYE ,  BAKER TERENCE SEWARD ,  LAWSON ALASTAIR DAVID GRIFFITHS ,  LIU XIAOFENG

    IPC: G06F19/00 ,  G06F19/16

    CPC classification number: G06F19/12 ,  C07K16/244 ,  C07K2317/55 ,  C07K2317/76 ,  G06F19/16 ,  G06F19/706 ,  G06F19/709

    Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.

    Abstract translation: 涉及设计一种将结合大分子靶标的结合位点的配位体或者鉴定对配体的修饰以改善配体对大分子靶标的结合位点的亲和力的方法和相关设备，包括使用关于 从生物大分子数据库中提取的非键合，分子内或分子间或分子间原子与原子接触，以鉴定与特定原子类型的结合位点相邻的有利区域，并修饰候选配体以增加候选配体的原子之间的相交 和优惠地区。 方法的一个或多个步骤可以由计算机执行。

    DE NOVO ANTIBODY DESIGN
    3.
    发明专利
    DE NOVO ANTIBODY DESIGN 未知

    公开(公告)号：SG11201804381SA

    公开(公告)日：2018-06-28

    申请号：SG11201804381S

    申请日：2016-12-01

    Applicant: UCB BIOPHARMA SPRL

    Inventor： BAKER TERENCE SEWARD ,  LIU XIAOFENG ,  SHI JIYE ,  TAYLOR RICHARD DAVID

    IPC: G06F19/16

    Abstract: Computer-implemented methods of designing an antibody that will bind to a target epitope are disclosed. In one arrangement, the method comprises identifying one or more hotspot residues that will each bind to a corresponding one of one or more hotspot sites on the target epitope. Candidate antibody structures are selected from a database such that characteristic atoms within the antibody structure and hotspot characteristic atoms can be superimposed computationally with an averaged spatial deviation less than a predetermined threshold. A designed antibody is generated by replacing matching residues with different residues such that a predicted affinity is increased.

    OBTAINING AN IMPROVED THERAPEUTIC LIGAND
    7.
    发明专利
    OBTAINING AN IMPROVED THERAPEUTIC LIGAND 未知

    公开(公告)号：SG10201707917UA

    公开(公告)日：2017-10-30

    申请号：SG10201707917U

    申请日：2014-06-13

    Applicant: UCB BIOPHARMA SPRL

    Inventor： SHI JIYE ,  BAKER TERENCE SEWARD ,  LAWSON ALASTAIR DAVID GRIFFITHS ,  LIU XIAOFENG

    Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.

    DE NOVO ANTIBODY DESIGN
    8.
    发明专利
    DE NOVO ANTIBODY DESIGN 未知

    公开(公告)号：CA3006677A1

    公开(公告)日：2017-06-08

    申请号：CA3006677

    申请日：2016-12-01

    Applicant: UCB BIOPHARMA SPRL

    Inventor： BAKER TERENCE SEWARD ,  LIU XIAOFENG ,  SHI JIYE ,  TAYLOR RICHARD DAVID

    IPC: G06F19/16

    Abstract: Computer-implemented methods of designing an antibody that will bind to a target epitope are disclosed. In one arrangement, the method comprises identifying one or more hotspot residues that will each bind to a corresponding one of one or more hotspot sites on the target epitope. Candidate antibody structures are selected from a database such that characteristic atoms within the antibody structure and hotspot characteristic atoms can be superimposed computationally with an averaged spatial deviation less than a predetermined threshold. A designed antibody is generated by replacing matching residues with different residues such that a predicted affinity is increased.

    ANTICUERPOS DE UNION A TAU
    10.
    发明专利
    ANTICUERPOS DE UNION A TAU 未知

    公开(公告)号：PE20180481A1

    公开(公告)日：2018-03-07

    申请号：PE2017002750

    申请日：2016-07-05

    Applicant: UCB BIOPHARMA SPRL

    Inventor： KNIGHT DAVID EDWARD ORMONDE ,  BAKER TERENCE SEWARD ,  MCMILLAN DAVID JAMES ,  GRIFFIN ROBERT ANTHONY ,  MAIRET-COELLO GEORGES ,  DOWNEY PATRICK ,  COURADE JEAN-PHILIPPE

    IPC: C07K14/47 ,  C07K16/18

    Abstract: Referido a un anticuerpo aislado de union a Tau o fragmento de union del mismo caracterizado porque comprende una region variable de cadena ligera que comprende una CDR1 seleccionada a partir de SEQ ID No.: 1, una CDR2 seleccionada a partir de SEQ ID No.: 2 y una CDR3 seleccionada a partir de SEQ ID No.: 3; y una region variable de cadena pesada que comprende una CDR1 seleccionada a partir de SEQ ID No.: 4, una CDR2 seleccionada a partir de SEQ ID No.: 5, y/o una CDR3 seleccionada a partir de SEQ ID No.: 6. Tambien se refiere a una molecula aislada de acido nucleico, que codifica para la cadena ligera y/o pesada de un anticuerpo de union a Tau; un vector de clonacion o expresion, una celula hospedadora, y un metodo para producir un anticuerpo de union a Tau; en donde se utilizan en el tratamiento de una tauopatia, como en la enfermedad de Alzheimer o en la paralisis supranuclear progresiva.

Patent Agency Ranking