-
公开(公告)号：JP2014012001A
公开(公告)日：2014-01-23
申请号：JP2013155968
申请日：2013-07-26
Applicant: Amgen , アムジエン・インコーポレーテツド , Ucb Pharma Sa , ユーシービー ファーマ ソシエテ アノニム
Inventor： PASZTY CHRISTOPHER , MARTYN KIM ROBINSON , KEVIN GRAHAM , ALISTAIR JAMES HENRY , KELLY SUE HOFFMANN , JOHN LATHAM , LU HSIENG SEN , ALASTAIR LAWSON , ANDY POPPLEWELL , SHEN WENYAN , DAVID WINKLER , AARON GEORGE WINTERS
IPC: C12N15/09 , A61K39/395 , A61P19/08 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12P21/08
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: PROBLEM TO BE SOLVED: To provide epitopes of sclerostin protein, including human sclerostin protein, and binding agents (such as antibodies) capable of binding to sclerostin or fragments thereof.SOLUTION: An antibody includes a light chain variable domain of a specific amino acid sequence and a heavy chain variable domain of another specific amino acid sequence, and binds to sclerostin with a binding affinity (Kd) less than or equal to 1×10M. Also provided are a method of producing the antibody, and a pharmaceutical composition containing the antibody.
Abstract translation: 要解决的问题：提供包含人类硬化蛋白的软骨素蛋白质表位，以及能够结合硬化蛋白酶或其片段的结合剂（例如抗体）。解决方案：抗体包括特定氨基酸序列的轻链可变结构域 和另一个特定氨基酸序列的重链可变结构域，并以小于或等于1×10M的结合亲和力（Kd）结合硬化蛋白。 还提供了产生抗体的方法和含有该抗体的药物组合物。
-
公开(公告)号：JP2014061000A
公开(公告)日：2014-04-10
申请号：JP2013245908
申请日：2013-11-28
Applicant: Amgen , アムジエン・インコーポレーテツド , Ucb Pharma Sa , ユーシービー ファーマ ソシエテ アノニム
Inventor： PASZTY CHRISTOPHER , MARTYN KIM ROBINSON , KEVIN GRAHAM , ALISTAIR JAMES HENRY , KELLY SUE HOFFMANN , JOHN LATHAM , LU HSIENG SEN , ALASTAIR LAWSON , ANDY POPPLEWELL , SHEN WENYAN , DAVID WINKLER , AARON GEORGE WINTERS
IPC: C12N15/09 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/02 , A61P3/04 , A61P3/10 , A61P5/14 , A61P5/18 , A61P7/06 , A61P15/00 , A61P17/00 , A61P19/00 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P25/32 , A61P29/00 , C07K16/18 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , G01N33/53
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: PROBLEM TO BE SOLVED: To provide therapeutic substances that can be used to enhance bone formation and bone density of animals including humans.SOLUTION: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding action substances such as antibodies capable of binding to sclerostin are provided.
Abstract translation: 要解决的问题：提供可用于增强包括人类在内的动物的骨形成和骨密度的治疗物质。解决方案：与硬皮蛋白的表位有关的组合物和方法，以及硬结蛋白结合作用物质，例如能结合硬化蛋白的抗体 被提供。
-
公开(公告)号：JP2014177470A
公开(公告)日：2014-09-25
申请号：JP2014095921
申请日：2014-05-07
Applicant: Amgen , アムジエン・インコーポレーテツド , Ucb Pharma Sa , ユーシービー ファーマ ソシエテ アノニム
Inventor： LU HSIENG SEN , PASZTY CHRISTOPHER , MARTYN KIM ROBINSON , ALISTAIR JAMES HENRY , KELLY SUE HOFFMANN , JOHN LATHAM , ALASTAIR LAWSON , DAVID WINKLER , AARON GEORGE WINTERS
IPC: C07K14/47 , A61K39/00 , A61P19/08 , A61P19/10 , C07K1/12 , C07K16/18 , C12N15/09 , C12P21/06 , C12P21/08
CPC classification number: C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
Abstract: PROBLEM TO BE SOLVED: To provide compositions and methods that can be used to increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength.SOLUTION: The invention provides compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin.
Abstract translation: 要解决的问题：提供可用于增加骨形成，骨矿物质密度，骨矿物质含量，骨量，骨质量和骨强度中的至少一种的组合物和方法。解决方案：本发明提供了与 硬骨素蛋白表位和硬化蛋白结合剂，例如能结合硬化蛋白的抗体。
-
Patent Agency Ranking
公开(公告)号：BRPI0610197B8
公开(公告)日：2021-05-11
申请号：BRPI0610197
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： AARON GEORGE WINTERS , ALASTAIR LAWSON , ALISTAIR JAMES HENRY , ANDY POPPLEWELL , CHRISTOPHER PASZTY , DAVID WINKLER , HSIENG SEN LU , JOHN LATHAM , KELLY SUE HOFFMANN , KEVIN GRAHAM , MARTYN KIM ROBINSON , WENYAN SHEN
Abstract: agentes de ligação de esclerostina são descritas composições e métodos relacionados aos epítopos da proteína esclerostina, e agentes de ligação de esclerostina, tais como anticorpos capazes de se ligarem à esclerostina.
-
公开(公告)号：BR122020023315B1
公开(公告)日：2021-06-08
申请号：BR122020023315
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： AARON GEORGE WINTERS , ALASTAIR LAWSON , ALISTAIR JAMES HENRY , ANDY POPPLEWELL , CHRISTOPHER PASZTY , DAVID WINKLER , HSIENG SEN LU , JOHN LATHAM , KELLY SUE HOFFMANN , KEVIN GRAHAM , MARTYN KIM ROBINSON , WENYAN SHEN
Abstract: são descritas composições e métodos relacionados aos epítopos da proteína esclerostina, e agentes de ligação de esclerostina, tais como anticorpos capazes de se ligarem à esclerostina.
-
公开(公告)号：MX358705B
公开(公告)日：2018-08-31
申请号：MX2013011425
申请日：2006-04-28
Applicant: UCB PHARMA SA
Inventor： CHRISTOPHER PASZTY , MARTYN KIM ROBINSON , KEVIN GRAHAM , ALISTAIR JAMES HENRY , KELLY SUE HOFFMAN , JOHN LATHAM , HSIENG SEN LU , ALASTAIR LAWSON , ANDY POPPLEWELL , WENYAN SHEN , DAVID WINKLER , AARON GEORGE WINTERS
Abstract: La presente invención se refiere a composiciones y métodos relacionados a los epitopes de la proteína de esclerostina, y agentes de unión de esclerostina, tales como anticuerpos capaces de unirse a la esclerostina.
-
公开(公告)号：BRPI0610197B1
公开(公告)日：2021-05-21
申请号：BRPI0610197
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： AARON GEORGE WINTERS , ALASTAIR LAWSON , ALISTAIR JAMES HENRY , ANDY POPPLEWELL , CHRISTOPHER PASZTY , DAVID WINKLER , HSIENG SEN LU , JOHN LATHAM , KELLY SUE HOFFMANN , KEVIN GRAHAM , MARTYN KIM ROBINSON , WENYAN SHEN
Abstract: agentes de ligação de esclerostina são descritas composições e métodos relacionados aos epítopos da proteína esclerostina, e agentes de ligação de esclerostina, tais como anticorpos capazes de se ligarem à esclerostina.
-
公开(公告)号：SG10201403400UA
公开(公告)日：2014-10-30
申请号：SG10201403400U
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： CHRISTOPHER PASZTY , MARTYN KIM ROBINSON , KEVIN GRAHAM , ALISTAIR JAMES HENRY , KELLY SUE HOFFMAN , JOHN LATHAM , ALASTAIR LAWSON , LU HSIENG SEN , ANDY POPPLEWELL , SHEN WENYAN , DAVID WINKLER , AARON GEORGE WINTERS
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.027 seconds)
