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公开(公告)号：JP2013249303A
公开(公告)日：2013-12-12
申请号：JP2013155969
申请日：2013-07-26
Applicant: Amgen , アムジエン・インコーポレーテツド , Ucb Pharma Sa , ユーシービー ファーマ ソシエテ アノニム
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTY KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LU HSIENG SEN , LAWSON ALASTAIR , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
IPC: A61K39/395 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/02 , A61P3/04 , A61P3/10 , A61P5/14 , A61P5/18 , A61P7/00 , A61P7/06 , A61P15/00 , A61P17/00 , A61P19/00 , A61P19/02 , A61P19/10 , A61P25/08 , A61P29/00 , C07K16/26 , C12N15/02 , C12N15/09
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition that contains an antibody capable of binding to Sclerostin as a protein.SOLUTION: A pharmaceutical composition contains an antibody having a light chain variable domain consisting of an amino acid sequence shown by SEQ ID No. 376 and a heavy chain variable domain consisting of an amino acid sequence shown by SEQ ID No. 378. The antibody binds to Sclerostin as SEQ ID No. 1 with a binding affinity (Kd) lower than, or equal to, 1×10M. or bonds to the sucre loss Canis familiaris var. domesticus of SEQ ID NO 1 by binding affinity (Kd) equal to 1×10M. The pharmaceutical composition can be used for treatment or prevention of a pathologic disorder developed through the medium of Sclerostin or associated with a rise in the Sclerostin level.
Abstract translation: 要解决的问题：提供含有能够结合硬皮蛋白作为蛋白质的抗体的药物组合物。溶液：药物组合物含有具有由SEQ ID No.366所示的氨基酸序列组成的轻链可变结构域的抗体 和由SEQ ID No.378所示的氨基酸序列组成的重链可变结构域。抗体以低于或等于1×10M的结合亲和力（Kd）与SEQ ID No.1结合至硬化蛋白。 或结合到苏必莱失去犬科家族变种。 通过结合亲和力（Kd）等于1×10M的SEQ ID NO 1的家蚕。 该药物组合物可用于治疗或预防通过硬化性白细胞介素发展或与硬皮蛋白血症水平升高相关的病理学疾病。
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公开(公告)号：HRP20211904T3
公开(公告)日：2022-03-04
申请号：HRP20211904
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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公开(公告)号：HRP20211904T1
公开(公告)日：2022-03-04
申请号：HRP20211904
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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公开(公告)号：PL3670528T3
公开(公告)日：2022-01-31
申请号：PL19211623
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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公开(公告)号：EA021539B1
公开(公告)日：2015-07-30
申请号：EA200702402
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: Изобретениеотноситсяк связывающимсклеростинагентам, такимкакантитела, иихприменению.
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Patent Agency Ranking
公开(公告)号：AU2006242431B2
公开(公告)日：2012-11-08
申请号：AU2006242431
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： SHEN WENYAN , LATHAM JOHN , PASZTY CHRISTOPHER , POPPLEWELL ANDY , WINTERS AARON GEORGE , ROBINSON MARTYN KIM , HOFFMANN KELLY SUE , HENRY ALISTAIR JAMES , LU HSIENG SEN , GRAHAM KEVIN , WINKLER DAVID , LAWSON ALASTAIR
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：BRPI0610197A2
公开(公告)日：2010-06-01
申请号：BRPI0610197
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , JAMES ALISTAIR , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：ES2902548T3
公开(公告)日：2022-03-28
申请号：ES19211623
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMAN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: Un anticuerpo monoclonal que se une a esclerostina humana; aumenta al menos uno de formación de hueso, densidad mineral ósea, contenido mineral óseo, masa ósea, calidad ósea y fuerza ósea en un mamífero; y se une a una parte de la esclerostina humana que consiste en los aminoácidos 51-64, 73-90, 101-117 y 138-149 de la SEQ ID NO: 1, en donde dicha parte tiene las tres de: (a) un enlace disulfuro entre los aminoácidos 57 y 111; (b) un enlace disulfuro entre los aminoácidos 82 y 142; y (c) un enlace disulfuro entre los aminoácidos 86 y 144.
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公开(公告)号：SI3670528T1
公开(公告)日：2022-01-31
申请号：SI200632414
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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公开(公告)号：NO345294B1
公开(公告)日：2020-11-30
申请号：NO20076046
申请日：2007-11-23
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： LATHAM JOHN , PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
IPC: A61K39/395 , A61P19/08 , A61P19/10
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