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公开(公告)号：JP2013249303A
公开(公告)日：2013-12-12
申请号：JP2013155969
申请日：2013-07-26
Applicant: Amgen , アムジエン・インコーポレーテツド , Ucb Pharma Sa , ユーシービー ファーマ ソシエテ アノニム
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTY KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LU HSIENG SEN , LAWSON ALASTAIR , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
IPC: A61K39/395 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/02 , A61P3/04 , A61P3/10 , A61P5/14 , A61P5/18 , A61P7/00 , A61P7/06 , A61P15/00 , A61P17/00 , A61P19/00 , A61P19/02 , A61P19/10 , A61P25/08 , A61P29/00 , C07K16/26 , C12N15/02 , C12N15/09
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition that contains an antibody capable of binding to Sclerostin as a protein.SOLUTION: A pharmaceutical composition contains an antibody having a light chain variable domain consisting of an amino acid sequence shown by SEQ ID No. 376 and a heavy chain variable domain consisting of an amino acid sequence shown by SEQ ID No. 378. The antibody binds to Sclerostin as SEQ ID No. 1 with a binding affinity (Kd) lower than, or equal to, 1×10M. or bonds to the sucre loss Canis familiaris var. domesticus of SEQ ID NO 1 by binding affinity (Kd) equal to 1×10M. The pharmaceutical composition can be used for treatment or prevention of a pathologic disorder developed through the medium of Sclerostin or associated with a rise in the Sclerostin level.
Abstract translation: 要解决的问题：提供含有能够结合硬皮蛋白作为蛋白质的抗体的药物组合物。溶液：药物组合物含有具有由SEQ ID No.366所示的氨基酸序列组成的轻链可变结构域的抗体 和由SEQ ID No.378所示的氨基酸序列组成的重链可变结构域。抗体以低于或等于1×10M的结合亲和力（Kd）与SEQ ID No.1结合至硬化蛋白。 或结合到苏必莱失去犬科家族变种。 通过结合亲和力（Kd）等于1×10M的SEQ ID NO 1的家蚕。 该药物组合物可用于治疗或预防通过硬化性白细胞介素发展或与硬皮蛋白血症水平升高相关的病理学疾病。
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公开(公告)号：WO2009130459A2
公开(公告)日：2009-10-29
申请号：PCT/GB2009001026
申请日：2009-04-22
Applicant: UCB PHARMA SA , CESKA THOMAS ALLEN , HENRY ALISTAIR JAMES , SHI JIJYE
Inventor： CESKA THOMAS ALLEN , HENRY ALISTAIR JAMES , SHI JIJYE
IPC: C07K14/715
CPC classification number: C07K16/244 , C07K14/54 , C07K2299/00 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates neutralising epitopes of IL-17A and IL-17F and antibodies which bind those epitopes. The present invention also relates to the therapeutic uses of the antibody molecules and methods for producing them.
Abstract translation: 本发明涉及IL-17A和IL-17F的中和表位和与这些表位结合的抗体。 本发明还涉及抗体分子的治疗用途及其制备方法。
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公开(公告)号：WO2008061013A2
公开(公告)日：2008-05-22
申请号：PCT/US2007084276
申请日：2007-11-09
Applicant: AMGEN INC , UCB PHARMA SA , ROBINSON MARTYN KIM , PASZTY CHRISTOPHER J , HENRY ALISTAIR JAMES , LAWSON ALISTAIR , POPPLEWELL ANDY
Inventor： ROBINSON MARTYN KIM , PASZTY CHRISTOPHER J , HENRY ALISTAIR JAMES , LAWSON ALISTAIR , POPPLEWELL ANDY
IPC: C07K16/00
CPC classification number: C07K16/18 , C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: Compositions and methods relating to sclerostin binding agents, such as antibodies and polypeptides capable of binding to sclerostin, are provided.
Abstract translation: 提供了与硬骨素结合剂（例如能够结合硬化蛋白的抗体和多肽）相关的组合物和方法。
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公开(公告)号：HRP20211904T3
公开(公告)日：2022-03-04
申请号：HRP20211904
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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公开(公告)号：HRP20211904T1
公开(公告)日：2022-03-04
申请号：HRP20211904
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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Patent Agency Ranking
公开(公告)号：PL3670528T3
公开(公告)日：2022-01-31
申请号：PL19211623
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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公开(公告)号：EA021539B1
公开(公告)日：2015-07-30
申请号：EA200702402
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: Изобретениеотноситсяк связывающимсклеростинагентам, такимкакантитела, иихприменению.
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公开(公告)号：AU2006242431B2
公开(公告)日：2012-11-08
申请号：AU2006242431
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： SHEN WENYAN , LATHAM JOHN , PASZTY CHRISTOPHER , POPPLEWELL ANDY , WINTERS AARON GEORGE , ROBINSON MARTYN KIM , HOFFMANN KELLY SUE , HENRY ALISTAIR JAMES , LU HSIENG SEN , GRAHAM KEVIN , WINKLER DAVID , LAWSON ALASTAIR
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：AU2006242476B2
公开(公告)日：2012-05-31
申请号：AU2006242476
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： HOFFMANN KELLY SUE , HENRY ALISTAIR JAMES , WINTERS AARON GEORGE , WINKLER DAVID , ROBINSON MARTYN KIM , LU HSIENG SEN , LAWSON ALASTAIR , PASZTY CHRISTOPHER , LATHAM JOHN
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：HUE057097T2
公开(公告)日：2022-04-28
申请号：HUE19211623
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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