公开(公告)号：CA2805573A1

公开(公告)日：2012-02-02

申请号：CA2805573

申请日：2011-07-28

Applicant: UCB PHARMA SA

Inventor： SMITH BRYAN JOHN ,  KIRKE HELEN MARIE

IPC: G01N33/68

Abstract: A method of measuring acidic species generated by degradation of a Fab or Fab' component of a Fab-PEG or a Fab '-PEG comprising the steps of: a) cleaving the PEG and linker from the Fab-PEG or Fab '-PEG with an enzyme, b) optionally separating the PEG and linker generated in step a) from the Fab or Fab', to provide a Fab or Fab' and c) quantitatively analyzing acidic species associated with the cleaved Fab or Fab' and/or the cleaved PEG.

公开(公告)号：SG187545A1

公开(公告)日：2013-03-28

申请号：SG2013003538

申请日：2011-07-28

Applicant: UCB PHARMA SA

Inventor： SMITH BRYAN JOHN ,  KIRKE HELEN MARIE

Abstract: A method of measuring acidic species generated by degradation of a Fab or Fab' component of a Fab-PEG or a Fab '-PEG comprising the steps of: a) cleaving the PEG and linker from the Fab-PEG or Fab '-PEG with an enzyme, b) optionally separating the PEG and linker generated in step a) from the Fab or Fab', to provide a Fab or Fab' and c) quantitatively analyzing acidic species associated with the cleaved Fab or Fab' and/or the cleaved PEG.

公开(公告)号：AU2011284551A1

公开(公告)日：2013-01-31

申请号：AU2011284551

申请日：2011-07-28

Applicant: UCB PHARMA SA

Inventor： SMITH BRYAN JOHN ,  KIRKE HELEN MARIE

IPC: G01N33/68

Abstract: A method of measuring acidic species generated by degradation of a Fab or Fab' component of a Fab-PEG or a Fab '-PEG comprising the steps of: a) cleaving the PEG and linker from the Fab-PEG or Fab '-PEG with an enzyme, b) optionally separating the PEG and linker generated in step a) from the Fab or Fab', to provide a Fab or Fab' and c) quantitatively analyzing acidic species associated with the cleaved Fab or Fab' and/or the cleaved PEG.