公开(公告)号：IN2535DEN2012A

公开(公告)日：2015-08-28

申请号：IN2535DEN2012

申请日：2012-03-23

Applicant: UCB PHARMA SA

Inventor： RALPH ADAMS ,  LAURA HANCOCK ,  SAM PHILIP HEYWOOD

IPC: C07K16/46

Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest which are a VH/VL pair, wherein the two single domain antibodies are linked by a disulfide bond. Also provided are particular dual specificity antibody fusion proteins and other antibody fragments which are stabilised by a disulfide bond.