公开(公告)号：AU2010222693A1

公开(公告)日：2011-09-29

申请号：AU2010222693

申请日：2010-03-10

Applicant: UCB PHARMA SA

Inventor： NEIL GOZZARD ,  GRIFFITHS LAWSON ALASTAIR DAVID ,  JOHN LIGHTWOOD DANIEL ,  THOMAS PALFRAMAN ROGER ,  JOHN SMITH BRYAN ,  LOUISE TYSON KERRY

IPC: C07K16/24 ,  A61K39/395 ,  A61P11/06 ,  C07K16/46 ,  C12N15/13

Abstract: Antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：PH12013500858A1

公开(公告)日：2016-01-25

申请号：PH12013500858

申请日：2013-04-29

Applicant: UCB PHARMA SA ,  BIOGEN MA INC

Inventor： BURKLY LINDA C ,  FERRANT-ORGETTAS JANINE L ,  GARBER ELLEN A ,  YEN-MING HSU ,  LIHE SU ,  TAYLOR FREDERICK R ,  RALPH ADAMS ,  THOMAS BROWN DEREK ,  GEORGE POPPLEWELL ANDREW ,  KIM ROBINSON MARTYN ,  ANTHONY SHOCK ,  LOUISE TYSON KERRY

IPC: A61K39/395 ,  C07K16/28 ,  C12N15/13 ,  C12N15/63

Abstract: This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.

公开(公告)号：PH12014502274A1

公开(公告)日：2014-12-10

申请号：PH12014502274

申请日：2014-10-09

Applicant: UCB PHARMA SA

Inventor： MARGARET FINNEY HELENE ,  GRIFFITHS LAWSON ALASTAIR DAVID ,  GRAHAM SHAW STEVAN ,  JOHN SMITH BRYAN ,  LOUISE TYSON KERRY ,  LARA KEVORKIAN ,  CHRISTOPH MEIER ,  KAUSHIK SARKAR ,  ALAN ATHERFOLD PAUL

IPC: C07K16/28 ,  G01N33/53

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.