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公开(公告)号：JP2009108086A
公开(公告)日：2009-05-21
申请号：JP2008294819
申请日：2008-11-18
Applicant: Ucb Pharma Sa , ユセベ ファルマ ソシエテ アノニム
Inventor： POPPLEWELL ANDREW GEORGE , TICKLE SIMON PETER , ZINKEWICH-PEOTTI KAREN , MORRISON ROBERT KENDALL
IPC: C07K16/28 , C12N15/09 , A61K39/395 , A61K47/48 , A61P9/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/02 , C12P21/08
CPC classification number: C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
Abstract: PROBLEM TO BE SOLVED: To provide antibody molecules containing at least one CDR obtained from a mouse monoclonal antibody having specificity for human KDR. SOLUTION: A CDR grafted antibody in which at least one of the CDRs is a hybrid CDR is disclosed. Also DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases, in which VEGF and/or KDR are implicated, are disclosed. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 待解决的问题：提供含有至少一种CDR的抗体分子，其获自具有对人KDR特异性的小鼠单克隆抗体。 解决方案：公开了其中至少一个CDR是杂交CDR的CDR移植抗体。 还公开了编码抗体分子链，载体，转化的宿主细胞的DNA序列和抗体分子在其中涉及VEGF和/或KDR的疾病的治疗中的用途。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：DK1438340T3
公开(公告)日：2010-11-22
申请号：DK02800666
申请日：2002-10-10
Applicant: UCB PHARMA SA
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公开(公告)号：ES2351208T3
公开(公告)日：2011-02-01
申请号：ES02800666
申请日：2002-10-10
Applicant: UCB PHARMA SA
Inventor： POPPLEWELL ANDREW GEORGE , TICKLE SIMON PETER , MORRISON ROBERT KENDALL , ZINKEWICH-PEOTTI KAREN
IPC: C07K16/28 , C12N15/09 , A61K39/395 , A61K47/48 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/02 , C12P21/08
Abstract: Una molécula de anticuerpo que tiene especificidad para KDR humano, que comprende una región variable de la cadena pesada del SEQ ID NO: 15 y una región variable de la cadena ligera del SEQ ID NO: 16.
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公开(公告)号：PL208848B1
公开(公告)日：2011-06-30
申请号：PL37034402
申请日：2002-10-10
Applicant: UCB PHARMA SA
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Patent Agency Ranking
公开(公告)号：DE60237778D1
公开(公告)日：2010-11-04
申请号：DE60237778
申请日：2002-10-10
Applicant: UCB PHARMA SA
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公开(公告)号：AT482234T
公开(公告)日：2010-10-15
申请号：AT02800666
申请日：2002-10-10
Applicant: UCB PHARMA SA
Inventor： POPPLEWELL ANDREW GEORGE , TICKLE SIMON PETER , ZINKEWICH-PEOTTI KAREN , MORRISON ROBERT KENDALL
IPC: C07K16/28 , C12N15/09 , A61K39/395 , A61K47/48 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/02 , C12P21/08
Abstract: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.
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公开(公告)号：AU2002334135B2
公开(公告)日：2009-01-08
申请号：AU2002334135
申请日：2002-10-10
Applicant: UCB PHARMA SA
Inventor： ZINKEWICH-PEOTTI KAREN , POPPLEWELL ANDREW GEORGE , TICKLE SIMON PETER , MORRISON ROBERT KENDALL
IPC: C12N15/09 , A61K39/395 , A61K47/48 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/02 , C12P21/08
Abstract: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.
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公开(公告)号：AU2002334135B8
公开(公告)日：2009-01-29
申请号：AU2002334135
申请日：2002-10-10
Applicant: UCB PHARMA SA
Inventor： ZINKEWICH-PEOTTI KAREN , POPPLEWELL ANDREW GEORGE , TICKLE SIMON PETER , MORRISON ROBERT KENDALL
IPC: C12N15/09 , A61K39/395 , A61K47/48 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/02 , C12P21/08
Abstract: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.
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公开(公告)号：NZ532758A
公开(公告)日：2008-04-30
申请号：NZ53275802
申请日：2002-10-10
Applicant: UCB PHARMA SA
Inventor： POPPLEWELL ANDREW GEORGE , TICKLE SIMON PETER , ZINKEWICH-PEOTTI KAREN , MORRISON ROBERT KENDALL
IPC: C12N15/09 , A61K39/395 , A61K47/48 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/02 , C12P21/08 , C12N15/70
Abstract: Disclosed are antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.
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