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    1.
    发明专利
    未知

    公开(公告)号：DE19512481C2

    公开(公告)日：2001-01-25

    申请号：DE19512481

    申请日：1995-04-04

    Applicant: UNIV CALIFORNIA

    Inventor： NELSON J STUART ,  MILNER THOMAS E ,  SVAASAND LARS O

    IPC: A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61B18/02 ,  A61B18/18 ,  A61B18/20 ,  A61B18/22 ,  A61F9/007 ,  A61N5/04 ,  A61N5/06 ,  A61N5/067 ,  A61N7/00

    Abstract: Dynamically cooling the epidermis of a port wine stain patient undergoing laser therapy permits maximization of the thermal damage to the port wine stain while at the same time minimizing nonspecific injury to the normal overlying epidermis. A cryogenic spurt is applied to the skin surface for a predetermined short period of time in the order of tens of milliseconds so that the cooling remains localized in epidermis while leaving the temperature of deeper port wine stain vessels substantially unchanged. The result is that epidermal denaturation and necrosis which normally occurs in uncooled laser irradiated skin sites does not occur and that clinically significant blanching of the port wine stains at the dynamically cooled sites establishes that selective laser photothermolysis of the port wine stain blood vessels is achieved. In addition, dynamic epidermal cooling reduces patient discomfort normally associated with flashlamp-pumped pulsed dye laser therapy.

    DYNAMIC COOLING OF HUMAN SKIN USING A NONTOXIC CRYOGEN WITH NO OZONE DEPLETION AND MINIMAL GLOBAL WARMING POTENTIAL
    2.
    发明申请
    DYNAMIC COOLING OF HUMAN SKIN USING A NONTOXIC CRYOGEN WITH NO OZONE DEPLETION AND MINIMAL GLOBAL WARMING POTENTIAL 审中-公开
    用无毒低温无臭氧消毒人体皮肤的动态冷却和极小的全球变暖潜势

    公开(公告)号：WO2008027847A3

    公开(公告)日：2008-04-17

    申请号：PCT/US2007076913

    申请日：2007-08-27

    Applicant: UNIV CALIFORNIA ,  NELSON J STUART ,  SVAASAND LARS O

    Inventor： NELSON J STUART ,  SVAASAND LARS O

    IPC: A61N5/06 ,  A61B18/18

    CPC classification number: A61B18/203 ,  A61B18/02 ,  A61B18/20 ,  A61B2018/00029 ,  A61B2018/00452 ,  C09K5/06

    Abstract: An improvement in a method for providing localized cooling of tissue when thermally mediated by electromagnetic radiation comprises directing at least one spurt of a heat transferring substance onto a selected location on the tissue, and preventing ignition of the heat transferring substance by heating from the electromagnetic radiation. Preferably liquid carbon dioxide under pressure is supplied as the heat transferring substance, and adiabatically expanded to provide a solid carbon dioxide spray onto the selected location.

    Abstract translation: 用于在由电磁辐射热介导时提供组织的局部冷却的方法的改进包括将热传递物质的至少一个喷射引导到组织上的选定位置，并且通过从电磁辐射加热来防止传热物质的点燃 。 优选地，加压下的液态二氧化碳作为传热物质被提供，并且绝热膨胀以提供固体二氧化碳喷雾到所选位置。

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