公开(公告)号：JP2003159088A

公开(公告)日：2003-06-03

申请号：JP2002259364

申请日：2002-09-04

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： COUGHLIN SHAUN R ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/74 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53

Abstract: PROBLEM TO BE SOLVED: To provide materials involved in the control of the circulatory system, more specifically, to provide a recombinant material useful for the production of a thrombin receptor, to provide use of the receptor as a diagnostic tool, and to provide a therapeutic agent which either stimulates or blocks thrombin receptor activation and diagnostic compositions relevant to the receptor. SOLUTION: The materials include a mutant thrombin, a DNA molecule, and a recombinant host cell; wherein the mutant thrombin, producible in a recombinant way, is such that the 57- and/or 99- and/or 205-position(s) is (are) different from that(those) in a wild-type thrombin b-chain, the DNA molecule has an expression system capable of producing the thrombin in a host when transformed to the recombinant host and includes a DNA sequence encoding the thrombin linked agonistically to an abnormal regulatory sequence so that the expression system is operable in the host, and the recombinant host cell is subject to transformation by the expression system. COPYRIGHT: (C)2003,JPO

公开(公告)号：EP0572553A4

公开(公告)日：1995-02-01

申请号：EP92907700

申请日：1992-02-19

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： COUGHLIN SHAUN R ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/74 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53 ,  C07K7/00 ,  C07K13/00 ,  C07K15/28 ,  C12N15/63

CPC classification number: C12N9/6429 ,  A61K38/00 ,  A61K39/00 ,  C07K14/705 ,  C07K16/28 ,  C12Y304/21005 ,  Y10S530/837

公开(公告)号：AT247165T

公开(公告)日：2003-08-15

申请号：AT92907700

申请日：1992-02-19

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： COUGHLIN SHAUN R ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/74 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53 ,  C07K7/00 ,  C07K14/00 ,  C12N15/63

公开(公告)号：IE920530A1

公开(公告)日：1992-08-26

申请号：IE920530

申请日：1992-02-19

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： COUGHLIN SHAUN R ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/74 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53 ,  C07K5/00 ,  C07K13/00 ,  C12N15/00 ,  G01N33/00

公开(公告)号：AU665752B2

公开(公告)日：1996-01-18

申请号：AU1456892

申请日：1992-02-19

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： COUGHLIN SHAUN R ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/74 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53 ,  C07K7/00 ,  A61K37/02 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07K7/08 ,  C07K13/00

公开(公告)号：NZ241666A

公开(公告)日：1995-07-26

申请号：NZ24166692

申请日：1992-02-19

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： COUGHLIN SHAUN R ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/74 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53 ,  A61K37/02 ,  C07K5/10 ,  C07K7/08 ,  C07K15/28 ,  G01N33/50

公开(公告)号：CA2104394A1

公开(公告)日：1992-08-20

申请号：CA2104394

申请日：1992-02-19

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： COUGHLIN SHAUN R ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/74 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53 ,  C12N15/57 ,  A61K38/04 ,  A61K38/48 ,  C07K5/10 ,  C07K7/04 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/573

Abstract: 2104394 9214750 PCTABS00015 The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at cell surfaces and is useful in assay systems both for the detection of thrombin and for the evaluation of candidate thrombin agonists and antagonists. Further, the elucidation of the structure of the thrombin receptor permits the design of agonist and antagonist compounds which are useful diagnostically and therapeutically. The availability of the thrombin receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof which are also useful diagnostically or therapeutically.

公开(公告)号：DE69233157T2

公开(公告)日：2004-05-19

申请号：DE69233157

申请日：1992-02-19

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： COUGHLIN SHAUN R ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/74 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53 ,  C07K7/00 ,  C07K14/00 ,  C12N15/63

公开(公告)号：DE69233157D1

公开(公告)日：2003-09-18

申请号：DE69233157

申请日：1992-02-19

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： COUGHLIN SHAUN R ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/74 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53 ,  C07K7/00 ,  C07K14/00 ,  C12N15/63

公开(公告)号：JP2002136296A

公开(公告)日：2002-05-14

申请号：JP2001269587

申请日：2001-09-05

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K35/58 ,  A61P7/02 ,  C07K1/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/75 ,  C07K16/00 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12R1/91

Abstract: PROBLEM TO BE SOLVED: To provide another method of antithrombosis treatment by specifically inhibiting the bonding of vWF to a GPIb-IX complex containing platelets. SOLUTION: A DNA molecule composition comprising DNA molecules each containing a sequence encoding a platelet anti-adhesive peptide obtained from snake venoms selected from the following group; Agkistrodon, Bitis, Bothrops, Cerastes, Crotalus, C, Echis carinatus sochurecki, Eristicophis macmahoni, Pseudocerastes persicus, Sistrurus, Trimeresurus, and Vipera.