公开(公告)号：EP2595535A4

公开(公告)日：2016-07-27

申请号：EP10855105

申请日：2010-07-22

Applicant: UNIV HAMPTON

Inventor： KEPPEL CYNTHIA E ,  GUEYE PAUL ,  SINESI CHRISTOPHER

IPC: A61B6/00 ,  A61B6/12

CPC classification number: G01T1/201 ,  A61M25/00 ,  A61N5/1048 ,  G01T1/161 ,  G01T1/2018

Abstract: An apparatus and method for in vivo and ex vivo control, detection and measurement of radiation in therapy, diagnostcs, and related applications accomplished through scintillating fiber detection. One example includes scintillating fibers placed along a delivery guide such as a catheter for measuring applied radiation levels during radiotherapy treatments, sensing locations of a radiation source, or providing feedback of sensed radiation. Another option is to place the fibers into a positioning device such as a balloon, or otherwise in the field of the radiation delivery. The scintillating fibers provide light output levels correlating to the levels of radiation striking the fibers and comparative measurement between fibers can be used for more extensive dose mapping. Adjustments to a radiation treatment may be made as needed based on actual and measured applied dosages as determined by the fiber detectors. Characteristics of a radiation source may also be measured using scintillating materials.

Abstract translation: 用于通过闪烁纤维检测实现的用于体内和离体控制，检测和测量治疗，诊断和相关应用中的辐射的装置和方法。 一个实例包括沿着诸如导管的输送导向器放置的闪烁纤维，用于在放射疗法治疗期间测量施加的辐射水平，感测辐射源的位置，或提供感测辐射的反馈。 另一种选择是将纤维放置在诸如球囊的定位装置中，或者在辐射传送领域中。 闪烁纤维提供与射入纤维的辐射水平相关的光输出水平，并且纤维之间的比较测量可用于更广泛的剂量映射。 可以根据纤维检测器确定的实际和测量的施用剂量根据需要进行放射治疗的调整。 也可以使用闪烁材料测量辐射源的特性。

公开(公告)号：WO2007126782A2

公开(公告)日：2007-11-08

申请号：PCT/US2007007520

申请日：2007-03-27

Applicant: UNIV HAMPTON ,  KEPPEL CYNTHIA E ,  BRITTEN RICHARD A ,  NAZARYAN VAHAGN R

Inventor： KEPPEL CYNTHIA E ,  BRITTEN RICHARD A ,  NAZARYAN VAHAGN R

IPC: A61N5/06 ,  G21K1/00

CPC classification number: A61N5/103 ,  A61N5/06 ,  A61N5/1031 ,  A61N2005/1087

Abstract: Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially- dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.

Abstract translation: 提供了治疗计划方法，其确定沿着束线的相对生物学效力（RBE）的变异性，并且计算应当施加什么强度的强子束如质子或碳离子束以实现期望的生物剂量 在患有疾病的患者的治疗部位。 通常，计算沿着束线的三个或四个对应的空间分散间隔处的三个或四个RBE值。 在一个实施方案中，治疗部位的扩展布拉格峰（SOBP）区域的两个RBE值; 计算一个用于近端部分，一个用于下降的远端部分。 可以针对SOBP的远端边缘区域确定第三和不同的RBE值。 也可以为前SOBP区域计算第四值。