公开(公告)号：WO2016025438A1

公开(公告)日：2016-02-18

申请号：PCT/US2015044588

申请日：2015-08-11

Applicant: UNIV ILLINOIS

Inventor： ROGERS JOHN A ,  GAO LI ,  MALYARCHUK VIKTOR ,  WEBB RICHARD CHAD

IPC: A61B5/01

CPC classification number: A61B5/015 ,  A61B5/002 ,  A61B5/01 ,  A61B5/02007 ,  A61B5/0205 ,  A61B5/0261 ,  A61B5/028 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0537 ,  A61B5/4875 ,  A61B5/6802 ,  A61B5/6824 ,  A61B5/683 ,  A61B5/6832 ,  A61B2560/04 ,  A61B2562/028 ,  A61B2562/0285 ,  A61B2562/164

Abstract: Tissue-mounted devices and methods for monitoring a thermal transport property (e.g., thermal conductivity, thermal diffusivity, heat capacity) of tissue, such as skin, are disclosed. The devices conformally mount to the tissue and comprise one or more thermal actuators and a plurality of sensors. The actuator applies heat to the tissue and the sensors detect a spatio temporal distribution of a physiological tissue parameter or physical property resulting from the heating. This spatio temporal information may be correlated with a rate, velocity and/or direction of blood flow, the presence of a vascular occlusion, circulation changes due to inflammation, hydration level and other physiological parameters.

Abstract translation: 公开了用于监测诸如皮肤的组织的热传递性质（例如，热导率，热扩散率，热容量）的组织安装装置和方法。 这些装置保形地安装到组织上并且包括一个或多个热致动器和多个传感器。 致动器对组织施加热量，并且传感器检测由加热产生的生理组织参数或物理性质的时空分布。 这种时空信息可能与血流的速率，速度和/或方向，血管闭塞的存在，由于炎症引起的循环变化，水合水平和其它生理参数相关。

公开(公告)号：WO2015051085A2

公开(公告)日：2015-04-09

申请号：PCT/US2014058768

申请日：2014-10-02

Applicant: UNIV ILLINOIS ,  UNIV ST LOUIS

Inventor： ROGERS JOHN A ,  EFIMOV IGOR ,  GUTBROD SARAH ,  XU LIZHI ,  BONIFAS ANDREW ,  WEBB RICHARD CHAD ,  KOH AHYEON

IPC: A61B5/00 ,  A61B5/03 ,  A61N2/00

CPC classification number: A61B5/686 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/015 ,  A61B5/02055 ,  A61B5/036 ,  A61B5/0422 ,  A61B5/0538 ,  A61B5/1107 ,  A61B5/1116 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/4836 ,  A61B5/6869 ,  A61B5/6885 ,  A61B18/14 ,  A61B2018/00351 ,  A61B2562/0215 ,  A61B2562/028 ,  A61B2562/046 ,  A61B2562/164 ,  A61F7/007 ,  A61H23/0245 ,  A61H2201/10 ,  A61N1/0563 ,  A61N1/0597 ,  A61N1/3621 ,  A61N1/375 ,  A61N2/002 ,  A61N2/006 ,  A61N5/0603 ,  A61N5/0622

Abstract: Provided are devices and methods capable of interfacing with biological tissues, such as organs like the heart, in real-time and using techniques which provide the ability to monitor and control complex physical, chemical, biochemical and thermal properties of the tissues as a function of time. The described devices and methods utilize micro scale sensors and actuators to spatially monitor and control a variety of physical, chemical and biological tissue parameters, such as temperature, pH, spatial position, force, pressure, electrophysiology and to spatially provide a variety of stimuli, such as heat, light, voltage and current.

Abstract translation: 提供能够实时地与诸如心脏之类的器官如生物组织接触的装置和方法，并且使用提供监测和控制组织的复杂物理，化学，生化和热性质的能力的技术作为 时间。 所描述的装置和方法利用微尺度传感器和致动器来空间监测和控制各种物理，化学和生物组织参数，例如温度，pH，空间位置，力，压力，电生理学，并且空间地提供各种刺激， 如热，光，电压和电流。

公开(公告)号：EP3179902A4

公开(公告)日：2018-04-11

申请号：EP15831510

申请日：2015-08-11

Applicant: UNIV ILLINOIS

Inventor： ROGERS JOHN A ,  GAO LI ,  MALYARCHUK VIKTOR ,  WEBB RICHARD CHAD

IPC: A61B5/01 ,  A61B5/00 ,  A61B5/02 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/028 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/053

CPC classification number: A61B5/015 ,  A61B5/002 ,  A61B5/0048 ,  A61B5/02007 ,  A61B5/0205 ,  A61B5/0261 ,  A61B5/028 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0537 ,  A61B5/4875 ,  A61B5/6802 ,  A61B5/6824 ,  A61B5/683 ,  A61B5/6832 ,  A61B2560/04 ,  A61B2562/0271 ,  A61B2562/028 ,  A61B2562/0285 ,  A61B2562/046 ,  A61B2562/12 ,  A61B2562/164

Abstract: Tissue-mounted devices and methods for monitoring a thermal transport property (e.g., thermal conductivity, thermal diffusivity, heat capacity) of tissue, such as skin, are disclosed. The devices conformally mount to the tissue and comprise one or more thermal actuators and a plurality of sensors. The actuator applies heat to the tissue and the sensors detect a spatio temporal distribution of a physiological tissue parameter or physical property resulting from the heating. This spatio temporal information may be correlated with a rate, velocity and/or direction of blood flow, the presence of a vascular occlusion, circulation changes due to in flammation, hydration level and other physiological parameters.

公开(公告)号：EP3052017A4

公开(公告)日：2017-06-14

申请号：EP14851143

申请日：2014-10-02

Applicant: UNIV ILLINOIS ,  WASHINGTON UNIV IN ST LOUIS

Inventor： ROGERS JOHN A ,  EFIMOV IGOR ,  GUTBROD SARAH ,  XU LIZHI ,  BONIFAS ANDREW ,  WEBB RICHARD CHAD ,  KOH AHYEON

IPC: A61B5/0408

CPC classification number: A61B5/686 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/015 ,  A61B5/02055 ,  A61B5/036 ,  A61B5/0422 ,  A61B5/0538 ,  A61B5/1107 ,  A61B5/1116 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/4836 ,  A61B5/6869 ,  A61B5/6885 ,  A61B18/14 ,  A61B2018/00351 ,  A61B2562/0215 ,  A61B2562/028 ,  A61B2562/046 ,  A61B2562/164 ,  A61F7/007 ,  A61H23/0245 ,  A61H2201/10 ,  A61N1/0563 ,  A61N1/0597 ,  A61N1/3621 ,  A61N1/375 ,  A61N2/002 ,  A61N2/006 ,  A61N5/0603 ,  A61N5/0622

Abstract: Provided are devices and methods capable of interfacing with biological tissues, such as organs like the heart, in real-time and using techniques which provide the ability to monitor and control complex physical, chemical, biochemical and thermal properties of the tissues as a function of time. The described devices and methods utilize micro scale sensors and actuators to spatially monitor and control a variety of physical, chemical and biological tissue parameters, such as temperature, pH, spatial position, force, pressure, electrophysiology and to spatially provide a variety of stimuli, such as heat, light, voltage and current.

Abstract translation: 提供了能够与生物组织如心脏等器官实时接口的装置和方法，并且使用能够监测和控制组织的复杂物理，化学，生物化学和热特性的技术作为 时间。 所描述的装置和方法利用微尺度传感器和致动器来在空间上监测和控制各种物理，化学和生物组织参数，例如温度，pH，空间位置，力，压力，电生理学，并且在空间上提供各种刺激， 如热，光，电压和电流。

公开(公告)号：AU2014329510A1

公开(公告)日：2016-04-21

申请号：AU2014329510

申请日：2014-10-02

Applicant: UNIV ILLINOIS ,  UNIV WASHINGTON

Inventor： ROGERS JOHN A ,  EFIMOV IGOR ,  GUTBROD SARAH ,  XU LIZHI ,  BONIFAS ANDREW ,  WEBB RICHARD CHAD ,  KOH AHYEON

IPC: A61B5/00 ,  A61B5/03 ,  A61B5/296 ,  A61N2/00

Abstract: Provided are devices and methods capable of interfacing with biological tissues, such as organs like the heart, in real-time and using techniques which provide the ability to monitor and control complex physical, chemical, biochemical and thermal properties of the tissues as a function of time. The described devices and methods utilize micro scale sensors and actuators to spatially monitor and control a variety of physical, chemical and biological tissue parameters, such as temperature, pH, spatial position, force, pressure, electrophysiology and to spatially provide a variety of stimuli, such as heat, light, voltage and current.

公开(公告)号：CA2926027A1

公开(公告)日：2015-04-09

申请号：CA2926027

申请日：2014-10-02

Applicant: UNIV ILLINOIS ,  UNIV ST LOUIS

Inventor： ROGERS JOHN A ,  EFIMOV IGOR ,  GUTBROD SARAH ,  XU LIZHI ,  BONIFAS ANDREW ,  WEBB RICHARD CHAD ,  KOH AHYEON

IPC: A61B5/00 ,  A61B5/03 ,  A61B5/296 ,  A61N2/00

Abstract: Provided are devices and methods capable of interfacing with biological tissues, such as organs like the heart, in real-time and using techniques which provide the ability to monitor and control complex physical, chemical, biochemical and thermal properties of the tissues as a function of time. The described devices and methods utilize micro scale sensors and actuators to spatially monitor and control a variety of physical, chemical and biological tissue parameters, such as temperature, pH, spatial position, force, pressure, electrophysiology and to spatially provide a variety of stimuli, such as heat, light, voltage and current.

公开(公告)号：CA2958168A1

公开(公告)日：2016-02-18

申请号：CA2958168

申请日：2015-08-11

Applicant: UNIV ILLINOIS

Inventor： ROGERS JOHN A ,  GAO LI ,  MALYARCHUK VIKTOR ,  WEBB RICHARD CHAD

IPC: A61B5/01 ,  A61B5/02 ,  A61B5/053

Abstract: Tissue-mounted devices and methods for monitoring a thermal transport property (e.g., thermal conductivity, thermal diffusivity, heat capacity) of tissue, such as skin, are disclosed. The devices conformally mount to the tissue and comprise one or more thermal actuators and a plurality of sensors. The actuator applies heat to the tissue and the sensors detect a spatio temporal distribution of a physiological tissue parameter or physical property resulting from the heating. This spatio temporal information may be correlated with a rate, velocity and/or direction of blood flow, the presence of a vascular occlusion, circulation changes due to inflammation, hydration level and other physiological parameters.