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公开(公告)号：WO2008055151A9
公开(公告)日：2008-10-23
申请号：PCT/US2007082989
申请日：2007-10-30
Applicant: UNIV KANSAS , UNIV KANSAS MEDICAL CENTER , BERKLAND CORY , STEHNO-BITTEL LISA A , SIAHAAN TERUNA
Inventor： BERKLAND CORY , STEHNO-BITTEL LISA A , SIAHAAN TERUNA
IPC: C12N5/00
CPC classification number: C12N5/0676 , A61K35/39 , A61L27/18 , A61L27/3882 , A61L27/3895 , C12N5/0677 , C12N2509/00 , C12N2533/40 , C12N2535/10 , C08L67/04
Abstract: An implantable biomaterial scaffold having islet cells or small islet cell clusters attached thereto in a multilayer. The cells are derived by enzymatic dispersion and/or calcium depletion of large adult intact islets.
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2.发明申请MICROSPHERE-BASED MATERIALS WITH PREDEFINED 3D SPATIAL AND TEMPORAL CONTROL OF BIOMATERIALS, POROSITY AND/OR BIOACTIVE SIGNALS 审中-公开具有预测的生物材料，多孔性和/或生物信号的3D空间和时间控制的基于微孔的材料
公开(公告)号：WO2009049230A8
公开(公告)日：2010-07-08
申请号：PCT/US2008079611
申请日：2008-10-10
Applicant: UNIV KANSAS , DETAMORE MICHAEL , SINGH MILLIND , SCURTO AARON M , BERKLAND CORY
Inventor： DETAMORE MICHAEL , SINGH MILLIND , SCURTO AARON M , BERKLAND CORY
CPC classification number: C12N5/0075 , C12N2533/10 , C12N2533/40
Abstract: A tissue engineering scaffold for growing cells can include a plurality of biocompatible microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three - dimensional matrix. The first and second characteristics can selected a composition, polymer, particle size, particle size distribution, type of bioactive agent, type of bioactive agent combination, bioactive agent concentration, amount of bioactive agent, rate of bioactive agent release, mechanical strength, flexibility, rigidity, color, radiotranslucency, radiopaqueness, or the like.
Abstract translation: 用于生长细胞的组织工程支架可以包括连接在一起以形成三维基质的多个生物相容性微球。 基质可以包括用于生长细胞的多个孔。 生物相容性微球可以包括第一组和第二组微球。 第一组微球可以具有第一特性，并且相对于三维矩阵具有第一预定空间分布。 第二组微球可以具有不同于第一特性的第二特性和与第一预定空间分布相对于三维矩阵不同的第二预定空间分布。 第一和第二特征可以选择组合物，聚合物，粒度，粒度分布，生物活性剂的类型，生物活性剂组合的类型，生物活性剂浓度，生物活性剂的量，生物活性剂释放速率，机械强度，柔韧性， 刚度，颜色，辐射透明度，无线电等等。
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3.发明公开POLYELECTROLYTE COMPLEXES AS DELAYED GELLING AGENTS FOR OIL AND GAS APPLICATIONS 审中-公开聚电解质复合AS带的石油和天然气应用延时凝胶化手段
公开(公告)号：EP2126281A4
公开(公告)日：2014-08-27
申请号：EP07841636
申请日：2007-08-30
Applicant: UNIV KANSAS
Inventor： BERKLAND CORY , CORDOVA MARY , LIANG JENN-TAI , WILLHITE G PAUL
CPC classification number: C09K8/512 , C09K2208/10
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4.发明公开
公开(公告)号：EP2542248A4
公开(公告)日：2013-04-17
申请号：EP11751292
申请日：2011-03-02
Applicant: UNIV KANSAS
Inventor： BERKLAND CORY , MOHAMMADI ZAHRA
IPC: A61K31/785
CPC classification number: A61K47/48076 , A61K9/0019 , A61K9/0056 , A61K31/785 , A61K47/547 , A61K47/58 , A61K47/595 , C08F8/00 , C08F18/22 , C08F26/02 , C08F126/02 , C08F2810/20 , C08G69/10 , C08G69/48 , C08G2210/00
Abstract: Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than one hydroxyl group at any position that is free, or a derivative of the chelator, or a salt of the chelator and methods of use.
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公开(公告)号：WO2014130250A2
公开(公告)日：2014-08-28
申请号：PCT/US2014014985
申请日：2014-02-06
Applicant: CONOCOPHILLIPS CO , UNIV KANSAS
Inventor： GUAN HUILI , BERKLAND CORY , MORADI-ARAGHI AHMED , LIANG JENN-TAI , CHRISTIAN TERRY M , NEEDHAM RILEY B , HEDGES JAMES H , CHENG MIN , SCULLY FAYE L
CPC classification number: C09K8/588 , C08F220/56 , C08F2800/10 , C08L33/26 , C09K8/594 , E21B33/138 , E21B43/164 , Y02P90/70
Abstract: The invention is directed to polymers that self-crosslink at acidic pH or can be crosslinked by phenolic agents in brine. Such polymers have lower viscosity and can be pumped deep into reservoirs, where they will cross link in situ, thus increasing their viscosity and/or form a gel and blocking thief zones. Methods of making and using such polymers are also provided.
Abstract translation: 本发明涉及在酸性pH下自交联或可在盐水中由酚类试剂进行交联的聚合物。 这样的聚合物具有较低的粘度并且可以深入泵入储层，在那里它们将原位交联，从而增加其粘度和/或形成凝胶并阻止小偷区。 还提供了制备和使用这些聚合物的方法。
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Patent Agency Ranking6.发明申请TEMPLATED ISLET CELLS AND SMALL ISLET CELL CLUSTERS FOR DIABETES TREATMENT 审中-公开模拟细胞和用于糖尿病治疗的小型细胞集群
公开(公告)号：WO2011126921A3
公开(公告)日：2012-01-19
申请号：PCT/US2011030775
申请日：2011-03-31
Applicant: UNIV KANSAS , BERKLAND CORY , STEHNO-BITTEL LISA A , SIAHAAN TERUNA , RAMACHANDRAN KARTHIK
Inventor： BERKLAND CORY , STEHNO-BITTEL LISA A , SIAHAAN TERUNA , RAMACHANDRAN KARTHIK
CPC classification number: C12N5/0677 , A61K35/39 , A61K45/06 , A61L27/18 , A61L27/3882 , A61L27/3895 , C12N5/0676 , C12N2509/00 , C12N2533/40 , C12N2535/10 , C08L67/04
Abstract: A scaffold having islet cells or small islet cell clusters attached thereto in a multilayer, and a micro-mold having divots for culturing islets, wherein islet formation is influenced by the shape and dimensions of the divots are disclosed.
Abstract translation: 具有在多层中附着有胰岛细胞或小胰岛细胞簇的支架，以及具有用于培养胰岛的细胞的微型模具，其中，胰岛形成受到影像的形状和尺寸的影响。
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公开(公告)号：WO2011163572A3
公开(公告)日：2014-03-27
申请号：PCT/US2011041792
申请日：2011-06-24
Applicant: UNIV KANSAS , BERKLAND CORY , SESTAK JOSHUA , SIAHAAN TERUNA J
Inventor： BERKLAND CORY , SESTAK JOSHUA , SIAHAAN TERUNA J
CPC classification number: A61K39/0008 , A61K31/436 , A61K39/385 , A61K47/549 , A61K47/593 , A61K47/61 , A61K47/6933 , A61K47/6937 , A61K47/6939 , A61K2039/6093 , A61K2039/627 , C07B43/00
Abstract: Bifunctional conjugate compositions are provided comprising a Signal- 1 moiety bound to a first polymer carrier, wherein the combined size of the Signal- 1 moiety and the first polymer carrier is about 1 nanometer to about 500 nanometers; and a Signal-2 moiety bound to a second polymer carrier, wherein the combined size of the Signal-2 moiety and the second polymer carrier is about 1 nanometer to about 500 nanometers. In some embodiments, the Signal- 1 moiety and the Signal-2 moiety are bound to the same polymer carrier. Associated methods are also provided.
Abstract translation: 提供双功能共轭组合物，其包含与第一聚合物载体结合的Signal-1部分，其中Signal-1部分和第一聚合物载体的组合尺寸为约1纳米至约500纳米; 和与第二聚合物载体结合的Signal-2部分，其中Signal-2部分和第二聚合物载体的组合尺寸为约1纳米至约500纳米。 在一些实施方案中，Signal-1部分和Signal-2部分与相同的聚合物载体结合。 还提供了相关的方法。
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8.发明申请MICROSPHERE-BASED MATERIALS WITH PREDEFINED 3D SPATIAL AND TEMPORAL CONTROL OF BIOMATERIALS, POROSITY AND/OR BIOACTIVE SIGNALS 审中-公开具有预测的生物材料，多孔性和/或生物信号的3D空间和时间控制的基于微孔的材料
公开(公告)号：WO2009049230A2
公开(公告)日：2009-04-16
申请号：PCT/US2008079611
申请日：2008-10-10
Applicant: UNIV KANSAS , DETAMORE MICHAEL , SINGH MILLIND , SCURTO AARON M , BERKLAND CORY
Inventor： DETAMORE MICHAEL , SINGH MILLIND , SCURTO AARON M , BERKLAND CORY
CPC classification number: C12N5/0075 , C12N2533/10 , C12N2533/40
Abstract: A tissue engineering scaffold for growing cells can include a plurality of biocompatible microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three - dimensional matrix. The first and second characteristics can selected a composition, polymer, particle size, particle size distribution, type of bioactive agent, type of bioactive agent combination, bioactive agent concentration, amount of bioactive agent, rate of bioactive agent release, mechanical strength, flexibility, rigidity, color, radiotranslucency, radiopaqueness, or the like.
Abstract translation: 用于生长细胞的组织工程支架可以包括连接在一起以形成三维基质的多个生物相容性微球。 基质可以包括用于生长细胞的多个孔。 生物相容性微球可以包括第一组和第二组微球。 第一组微球可以具有第一特性，并且相对于三维矩阵具有第一预定空间分布。 第二组微球可以具有不同于第一特性的第二特性和与第一预定空间分布相对于三维矩阵不同的第二预定空间分布。 第一和第二特征可以选择组合物，聚合物，粒度，粒度分布，生物活性剂的类型，生物活性剂组合的类型，生物活性剂浓度，生物活性剂的量，生物活性剂释放速率，机械强度，柔韧性， 刚度，颜色，辐射透明度，无线电等等。
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公开(公告)号：EP2946070A4
公开(公告)日：2016-09-14
申请号：EP13871933
申请日：2013-12-30
Applicant: CONOCOPHILLIPS CO , UNIV KANSAS
Inventor： GUAN HUILI , BERKLAND CORY , MORADI-ARAGHI AHMAD , LIANG JENN-TAI , CHRISTIAN TERRY M , NEEDHAM RILEY B , CHENG MIN , SCULLY FAYE L , HEDGES JAMES H
Abstract: The instant application relates to nanogels or compositions that hold multivalent metal ions until some level of nanogel degradation has occurred, then slowly release the multivalent metal ions for gelation with carboxylate containing polymers. Compositions comprising such nanogels, together with polymers that can be crosslinked with multivalent metal ions, allow the deployment of such mixtures in various applications, and greatly increased gelation times.
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10.发明公开
公开(公告)号：EP2922878A4
公开(公告)日：2016-05-25
申请号：EP13856552
申请日：2013-11-22
Applicant: CONOCOPHILLIPS CO , UNIV KANSAS
Inventor： MORADI-ARAGHI AHMAD , CHENG MIN , NEEDHAM RILEY B , HEDGES JAMES H , SARATHI RAMESH S , SCULLY FAYE L , CHRISTIAN TERRY M , GUAN HUILI , BERKLAND CORY , LIANG JENN-TAI
CPC classification number: C09K8/588 , E21B33/138 , E21B43/16
Abstract: The invention is directed to stable and labile crosslinked water swellable polymeric microparticles that can be further gelled, methods for making same, and their various uses in the hygiene and medical arts, gel electrophoresis, packaging, agriculture, the cable industry, information technology, in the food industry, papermaking, use as flocculation aids, and the like. More particularly, the invention relates to a composition comprising expandable polymeric microparticles having labile crosslinkers and stable crosslinkers, said microparticle mixed with a fluid and an unreacted tertiary crosslinker comprising PEI or other polyamine based tertiary crosslinker that is capable of further crosslinking the microparticle on degradation of the labile crosslinker and swelling of the particle, so as to form a stable gel. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric microparticles are injected into a well and when the heat and/or pH of the well cause degradation of the labile crosslinker and when the microparticle expands, the tertiary crosslinker crosslinks the polymer to form a stable gel, thus diverting water to lower permeability regions and improving oil recovery.
Abstract translation: 本发明涉及可以进一步凝胶化的稳定和不稳定的交联水溶胀性聚合物微粒，其制备方法及其在卫生和医学领域，凝胶电泳，包装，农业，电缆工业，信息技术， 食品工业，造纸，用作絮凝助剂等。 更具体地说，本发明涉及包含具有不稳定交联剂和稳定交联剂的可膨胀聚合物微粒的组合物，所述微粒与流体混合，以及包含PEI或其它聚胺基三级交联剂的未反应的叔交联剂，其能够在降解 不稳定的交联剂和颗粒的溶胀，从而形成稳定的凝胶。 特别重要的用途是作为石油生产中的注入流体，其中将可发性聚合物微粒注入井中，并且当井的热和/或pH引起不稳定交联剂的降解时，并且当微粒膨胀时，三价交联剂交联 聚合物形成稳定的凝胶，从而将水转移到渗透率较低的区域，并提高油的回收率。
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