公开(公告)号：AU4080493A

公开(公告)日：1993-12-13

申请号：AU4080493

申请日：1993-05-14

Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW THE

Inventor： SPIBEY NORMAN ,  JARRETT JAMES OSWALD

IPC: A61K39/21 ,  A61K39/00 ,  A61P31/12 ,  C07K14/00 ,  C07K14/15 ,  C07K14/435 ,  C07K19/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/49 ,  C12N15/62

公开(公告)号：AU7075691A

公开(公告)日：1991-08-21

申请号：AU7075691

申请日：1991-01-25

Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW THE

Inventor： SPIBEY NORMAN

IPC: A61K39/235 ,  A61K39/00 ,  A61P31/12 ,  A61P31/20 ,  C07K14/075 ,  C07K14/145 ,  C12N7/00 ,  C12N15/09 ,  C12N15/45 ,  C12N15/861 ,  C12N15/86 ,  C12N15/35 ,  C12N15/47 ,  C12N15/48 ,  C12N15/50 ,  A61K39/295

Abstract: A recombinant adenovirus acting as a vector for an antigen-producing gene (e.g. a rabies glycoprotein gene) comprises a CAV-2 strain modified to contain the promoter-gene sequence within the region from the SmaI site close to the end of the inverted terminal repeat up to the promoter for the early region 4 (E4). To assist replication the recombinant virus is transfected into a cell line expressing Ela proteins. The recombinant virus is used for the production of a corresponding vaccine.