公开(公告)号：AU5768986A

公开(公告)日：1986-11-27

申请号：AU5768986

申请日：1986-05-22

Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW THE

Inventor： PARTON ROGER ,  STEWART-TULL DUNCAN ERIC STEWA

IPC: A61K39/095 ,  A61K39/00 ,  A61K39/10 ,  C07K14/235 ,  C07K15/12 ,  C07K3/28

Abstract: The present invention provides a method of preparing a substantially non-toxic immunogenia preparation of pertussis toxic comprising treatment of pertussis toxin with a cerbo- diimide. The preparation may be used for vaccination against whooping cough as well as making vaccines for use in immunisation against whooping cough. Desirably the pertussis toxin is treated in the form of an intimate admixture with filamentous.