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    USE OF ANTIOXIDANTS AS RADIO-PROTECTIVE AGENTS
    1.
    发明申请
    USE OF ANTIOXIDANTS AS RADIO-PROTECTIVE AGENTS 审中-公开
    抗氧化剂作为无机保护剂的使用

    公开(公告)号：WO2016088116A1

    公开(公告)日：2016-06-09

    申请号：PCT/IB2015/059425

    申请日：2015-12-07

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： BARFETT, Joseph ,  MIKULIS, David ,  MURPHY, Kieran P.

    IPC: A61K31/385 ,  A61K31/015 ,  A61K31/198 ,  A61K31/352 ,  A61K31/375 ,  A61P17/16 ,  A61P17/18

    CPC classification number: A61K31/015 ,  A61K9/2004 ,  A61K9/4808 ,  A61K31/198 ,  A61K31/352 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K31/4045 ,  A61K33/00 ,  A61N2005/1094 ,  A61K2300/00

    Abstract: Compositions comprising a radio-protective agent and methods of using such compositions to attenuate or otherwise protect an organism from the adverse effects arising from exposure to ionizing radiation are disclosed. Preferably, the radio-protective agent is an antioxidant and serves to protect the DNA of the organism from damage due to free radicals generated by the ionizing radiation. The methods of use preferably entail determining the timing, duration, and amount of exposure to ionizing radiation and thereby tailoring the administration of the radio-protective agent to protect against the DNA damage expected to arise from such exposure. Potential sources of ionizing radiation include medical imaging (e.g., x-rays, computed tomography, and other techniques in nuclear medicine), radiation therapy, and exposure to radiation in the upper atmosphere (i.e., when flying in an aircraft or space craft).

    Abstract translation: 公开了包含放射性保护剂的组合物和使用这些组合物减弱或以其他方式保护生物免受由于暴露于电离辐射引起的不利影响的方法。 优选地，放射性保护剂是抗氧化剂并且用于保护生物体的DNA免受由电离辐射产生的自由基的损害。 使用的方法优选地需要确定暴露于电离辐射的时间，持续时间和数量，从而定制放射性保护剂的施用以防止由于这种暴露所预期的DNA损伤。 电离辐射的潜在来源包括医学成像（例如，x射线，计算机断层扫描和核医学中的其他技术），放射治疗和暴露于高层大气中的辐射（即在飞机或航天飞机中飞行时）。

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