公开(公告)号：WO2013106913A1

公开(公告)日：2013-07-25

申请号：PCT/CA2013/000042

申请日：2013-01-18

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： DONE, Susan Jane ,  CAWTHORN, Thomas Richard ,  MORENO, Juan Carlos ,  EVANS, Kenneth Robert ,  CHEN, Jian ,  ACKLOO, Suzanne Zobeeda

IPC: G01N33/48 ,  A61K31/138 ,  A61P35/00 ,  C12Q1/68 ,  G01N33/483 ,  G01N33/574 ,  G01N33/577 ,  G01N33/68 ,  C40B30/04

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N2800/52

Abstract: Described is a method of providing a prognosis for a subject having or suspected of having breast cancer by determining the level of one or more biomarkers in a test sample. A difference or similarity in the level of one or more biomarkers in the test sample with a control is used to provide a prognosis for the test subject. Also described are methods of identifying a subject with breast cancer who is responsive to hormone treatment. Optionally, the biomarkers include Decorin (DCN) and/or Endoplasmin (HSP90B1). Also described are kits and compositions that include biomarker-specific detection agents useful for performing the methods described herein.

Abstract translation: 描述了通过确定测试样品中一种或多种生物标志物的水平来为具有或怀疑患有乳腺癌的受试者提供预后的方法。 使用具有对照的测试样品中的一种或多种生物标志物的水平的差异或相似性用于为测试对象提供预后。 还描述了鉴定对激素治疗有反应的乳腺癌患者的方法。 任选地，生物标志物包括Decorin（DCN）和/或内啡肽（HSP90B1）。 还描述了包含可用于执行本文所述方法的生物标志物特异性检测剂的试剂盒和组合物。