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公开(公告)号：WO2020148722A1
公开(公告)日：2020-07-23
申请号：PCT/IB2020/050381
申请日：2020-01-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： DACOSTA, Ralph , OTTOLINO-PERRY, Kathryn , GIBSON, Christopher
Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of target such as a tumor or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A three-dimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.
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公开(公告)号：WO2019148268A1
公开(公告)日：2019-08-08
申请号：PCT/CA2019/000015
申请日：2019-02-01
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： DACOSTA, Ralph , GIBSON, Christopher , OTTOLINO-PERRY, Kathryn , ANANTHA, Nayana, Thalanki , DONE, Susan, Jane , LEONG, Wey-Liang , EASSON, Alexandra M.
Abstract: A method of assessing surgical margins is disclosed. The method includes, subsequent to administration of a compound configured to induce emissions of between about 600 nm and about 660 nm in cancerous tissue cells, positioning a distal end of a handheld, white light and fluorescence-based imaging device adjacent to a surgical margin. The method also includes, with the handheld device, substantially simultaneously exciting and detecting autofluorescence emissions of tissue cells and fluorescence emissions of the induced wavelength in tissue cells of the surgical margin. And, based on a presence or an amount of fluorescence emissions of the induced wavelength detected in the tissue cells of the surgical margin, determining whether the surgical margin is substantially free of at least one of precancerous cells, cancerous cells, and satellite lesions. The compound may be a non-activated, non-targeted compound such as ALA.
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公开(公告)号：WO2016011534A1
公开(公告)日：2016-01-28
申请号：PCT/CA2015/000444
申请日：2015-07-24
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： DACOSTA, Ralph
CPC classification number: G06T7/0016 , A61B5/0071 , A61B5/0077 , A61B5/445 , G01N21/6486 , G06T2207/10016 , G06T2207/10024 , G06T2207/10048 , G06T2207/10064 , G06T2207/30088 , G06T2207/30096
Abstract: Systems and methods for determining bacterial load in targets and tracking changes in bacterial load of targets over time are disclosed. An autofluorescence detection and collection device includes a light source configured to directly illuminate at least a portion of a target and an area around the target with excitation light causing at least one biomarker in the illuminated target to fluoresce. Bacterial autofluorescence data regarding the illuminated portion of the target and the area around the target is collected and analyzed to determine bacterial load of the illuminated portion of the target and area around the target. The autofluorescence data may be analyzed using pixel intensity. Changes in bacterial load of the target over time may be tracked. The target may be a wound in tissue.
Abstract translation: 公开了用于确定目标中的细菌负荷并随时间跟踪目标细菌负荷变化的系统和方法。 自发荧光检测和收集装置包括被配置为通过激发光直接照射靶的至少一部分和靶周围的区域的光源，使得被照射的靶中的至少一个生物标志物发荧光。 收集和分析关于目标的照射部分和靶周围的区域的细菌自发荧光数据，以确定目标的照射部分和靶周围的区域的细菌负荷。 可以使用像素强度来分析自发荧光数据。 可追踪目标随时间变化的细菌负荷。 目标可能是组织中的伤口。
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4.发明申请
公开(公告)号：WO2020148721A1
公开(公告)日：2020-07-23
申请号：PCT/IB2020/050380
申请日：2020-01-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： DACOSTA, Ralph , DUNHAM, Danielle
Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of a biological target such as a wound, a tumor, or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A three-dimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to track wound healing and to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.
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公开(公告)号：WO2020148720A1
公开(公告)日：2020-07-23
申请号：PCT/IB2020/050379
申请日：2020-01-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： DACOSTA, Ralph , OTTOLINO-PERRY, Kathryn , GIBSON, Christopher , ANANTHA, Nayana Thalanki , O'BRIEN, Cristiana
Abstract: A tissue phantom is disclosed. The tissue phantom includes a first portion having the optical properties of healthy tissue and a second portion having the optical properties of cancerous tissue. Additionally, a method of calibrating an optical instrument is disclosed. The method includes illuminating a tissue phantom with excitation light from the optical instrument, detecting optical emissions emitted by the tissue phantom in response to illumination with the excitation light, and calibrating the optical instrument based upon the detected fluorescence.
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Patent Agency Ranking
公开(公告)号：WO2015149188A1
公开(公告)日：2015-10-08
申请号：PCT/CA2015/050277
申请日：2015-04-07
Inventor： WU, Xiaoyu , GORDIJO, Claudia Regina , ABBASI, Azhar Z. , PRASAD, Preethy , DACOSTA, Ralph , MAEDA, Azusa
IPC: A61K9/14 , A61K47/02 , A61K47/30 , A61K47/42 , A61L31/12 , A61N5/00 , A61P35/00 , C01B13/00 , C01G1/02 , C07H21/00 , C07K17/00
CPC classification number: A61K41/0038 , A61K9/0019 , A61K9/14 , A61K9/5146 , A61K9/5169 , A61K33/32 , A61K47/32 , A61K47/34 , A61K47/42 , A61N5/10 , A61N5/1001 , A61N2005/1021 , A61N2005/1098 , C01G45/02 , C01P2002/72 , C01P2002/84 , C01P2004/04 , C01P2004/24 , C01P2004/64 , C01P2006/22
Abstract: Disclosed herein are multifunctional nanoparticle compositions. The compositions can be useful for the treatment of cancer by enhancing the anti-tumor effectiveness of radiation directed to a tissue, cell or a tumor and the methods of use thereof. The multifunctional nanoparticle composition comprises a metal oxide nanoparticle core;a functional coating on the surface of the metal oxide nanoparticle core; and a matrix carrier in which the coated nanoparticle is embedded.
Abstract translation: 本文公开了多功能纳米颗粒组合物。 该组合物可用于通过增强针对组织，细胞或肿瘤的辐射的抗肿瘤效力及其使用方法来治疗癌症。 所述多功能纳米颗粒组合物包含金属氧化物纳米颗粒核心;金属氧化物纳米颗粒核心表面上的功能涂层; 和其中嵌入被覆纳米颗粒的基质载体。
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7.发明公开
公开(公告)号：EP3911919A1
公开(公告)日：2021-11-24
申请号：EP20741439.2
申请日：2020-01-17
Applicant: University Health Network
Inventor： DACOSTA, Ralph , DUNHAM, Danielle
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公开(公告)号：EP3911941A1
公开(公告)日：2021-11-24
申请号：EP20741925.0
申请日：2020-01-17
Applicant: University Health Network
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9.发明公开
公开(公告)号：EP4322176A3
公开(公告)日：2024-03-20
申请号：EP23203744.0
申请日：2020-01-17
Applicant: University Health Network
Inventor： DACOSTA, Ralph , DUNHAM, Danielle
IPC: G01B11/24 , G01B11/25 , G01N21/64 , G01S17/89 , G06T15/00 , G06T7/30 , G06T7/50 , G16H30/40 , A61B5/107
Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of a biological target such as a wound, a tumor, or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A threedimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to track wound healing and to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.
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10.发明公开
公开(公告)号：EP4322176A2
公开(公告)日：2024-02-14
申请号：EP23203744.0
申请日：2020-01-17
Applicant: University Health Network
Inventor： DACOSTA, Ralph , DUNHAM, Danielle
IPC: G16H30/40
Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of a biological target such as a wound, a tumor, or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A threedimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to track wound healing and to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.
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