公开(公告)号：WO2021207828A1

公开(公告)日：2021-10-21

申请号：PCT/CA2021/050483

申请日：2021-04-12

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： BRAY, Mark R. ,  MASON, Jacqueline M. ,  WEI, Xin ,  DUNCAN, Gordon

IPC: A61K31/4436 ,  A61P37/02 ,  C07D495/04

Abstract: Disclosed herein is a method of treating a subject with aberrant cytokine release from a disease or condition or at risk of developing aberrant cytokine release from a disease or condition. The method comprises administering to the subject an effective amount of a compound represented by structural formula (I): (I) or a pharmaceutically acceptable salt thereof. The variables in structural formula (I) are as described herein.

公开(公告)号：EP4452266A1

公开(公告)日：2024-10-30

申请号：EP22908968.5

申请日：2022-12-21

Applicant: University Health Network

Inventor： BRAY, Mark R. ,  MASON, Jacqueline M. ,  WEI, Xin ,  DUNCAN, Gordon

IPC: A61K31/437 ,  A61P35/02 ,  C07D471/04

公开(公告)号：EP4135695A1

公开(公告)日：2023-02-22

申请号：EP21788245.5

申请日：2021-04-12

Applicant: University Health Network

Inventor： BRAY, Mark R. ,  MASON, Jacqueline M. ,  WEI, Xin ,  DUNCAN, Gordon

IPC: A61K31/4436 ,  A61P37/02 ,  C07D495/04