公开(公告)号：WO2021022367A1

公开(公告)日：2021-02-11

申请号：PCT/CA2020/051062

申请日：2020-08-03

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： LUPIEN, Mathieu ,  HAIBE-KAINS, Benjamin ,  MADANI TONEKABONI, Seyed Ali

IPC: G16B20/30 ,  C12Q1/6869 ,  G16B15/30

Abstract: The present disclosure relates to the development of methods for identifying cis-regulatory elements. Also disclosed herein are various methods including for example determining the tissue of origin of a biological sample, prognosis of a patient diagnosed with a cancer and their response to treatments.

公开(公告)号：WO2021142538A1

公开(公告)日：2021-07-22

申请号：PCT/CA2021/050027

申请日：2021-01-13

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： HAIBE-KAINS, Benjamin ,  MADANI TONEKABONI, Seyed Ali

IPC: G16B5/00 ,  C12Q1/00

Abstract: There is provided systems and methods of weighted individualized network extraction of molecular features associated with cells. The method including: receiving the cellular dataset; determining a correlation between each pair of molecular features in the cellular dataset using a correlation metric represented as edges in a population network; removing edges in the population network that fall below a predetermined confidence cut-off associated with a null distribution; ranking samples based on their values for each one of the features in each feature pair; defining a paired rank-score for each ranked sample; removing edges in the population network between samples that have a respective paired rank-score below the predetermined confidence cut-off associated with the null distribution; and outputting the population network representing a weighted individualized network.

公开(公告)号：WO2019222848A1

公开(公告)日：2019-11-28

申请号：PCT/CA2019/050699

申请日：2019-05-22

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： HAIBE-KAINS, Benjamin ,  CESCON, David

IPC: A61K31/519 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/517 ,  A61K31/52 ,  A61K31/55 ,  A61P35/00 ,  C12Q1/6809

Abstract: Provided herein are methods of treating cancers characterized by a high expression of SKA3 gene, such as: breast cancer, prostate cancer, endometrial cancer, ovarian cancer, brain cancer, skin cancer, thyroid cancer, lung cancer, mesothelioma cancer, bladder cancer, colorectal cancer, liver cancer, melanoma, glioblastoma, leukemia or lymphoma, comprising administering a therapeutically effective amount of a TTK inhibitor, such as: CFI-402257, BAY 1161909, BAY 1217389, AZ-3146, NMS-P715, TC Mpsl 12, reversine, Mpsl-IN-1, Mpsl-IN-2, Mpsl-IN-3, MPS BAY1, MPS BAY2a, MPS BAY2b, MPI-0479605, SP600125, S81694/NMS-P153; BOS172722; NTRC 0060-0; NTRC 1501-0; and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4008004A1

公开(公告)日：2022-06-08

申请号：EP20849724.8

申请日：2020-08-03

Applicant: University Health Network

Inventor： LUPIEN, Mathieu ,  HAIBE-KAINS, Benjamin ,  MADANI TONEKABONI, Seyed Ali

IPC: G16B20/30 ,  C12Q1/6869 ,  G16B15/30

公开(公告)号：EP3796914A1

公开(公告)日：2021-03-31

申请号：EP19808414.7

申请日：2019-05-22

Applicant: University Health Network

Inventor： HAIBE-KAINS, Benjamin ,  CESCON, David

IPC: A61K31/519 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/517 ,  A61K31/52 ,  A61K31/55 ,  A61P35/00 ,  C12Q1/6809