公开(公告)号：WO2022226632A1

公开(公告)日：2022-11-03

申请号：PCT/CA2022/050625

申请日：2022-04-22

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： KESHAVJEE, Shafique ,  CYPEL, Marcelo ,  LIU, Mingyao ,  JUVET, Stephen ,  MESAKI, Kumi

IPC: C12N15/85 ,  A61K31/7105 ,  A61K35/12 ,  A61K38/46 ,  A61P29/00 ,  A61P37/06 ,  C12N5/10 ,  C12N5/071 ,  C12N15/09 ,  C12N15/12 ,  C12N15/19 ,  C12N15/113

Abstract: The present disclosure relates generally to epigenetically and genetically modified organs and tissues and methods of producing same. In particular, the present disclosure is directed to organs and tissues that have been epigenetically and/or genetically modified at one or multiple loci to control inflammation-regulating or immune-regulating gene expression and thereby improve the condition of the organs and tissues.

公开(公告)号：EP4330405A1

公开(公告)日：2024-03-06

申请号：EP22794132.5

申请日：2022-04-22

Applicant: University Health Network

Inventor： KESHAVJEE, Shafique ,  CYPEL, Marcelo ,  LIU, Mingyao ,  JUVET, Stephen ,  MESAKI, Kumi

IPC: C12N15/85 ,  A61K31/7105 ,  A61K35/12 ,  A61K38/46 ,  A61P29/00 ,  A61P37/06 ,  C12N5/10 ,  C12N5/071 ,  C12N15/09 ,  C12N15/12 ,  C12N15/19 ,  C12N15/113