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公开(公告)号：WO2012059820A1
公开(公告)日：2012-05-10
申请号：PCT/IB2011/002953
申请日：2011-11-02
Applicant: UNIVERSITY HEALTH NETWORK , LI, Ren-Ke , ZENG, Faquan
Inventor： LI, Ren-Ke , ZENG, Faquan
CPC classification number: C08G63/664 , A61K9/0019 , A61K9/06 , A61K47/34 , A61K47/593 , A61K47/60 , C08G63/823
Abstract: Disclosed are temperature-sensitive hydrogels having a gelation temperature of above about 30° C. These hydrogels comprise diblock or triblock polymers of the type A-B. A-B-A or B-A-B wherein the A block comprises hydrophobic, biodegradable and non-swellable domains and the B block comprises hydrophilic and swellable domains. Examples of such hydrogel-forming triblock polymers are polyvalerolactone-polyethylene glycol-polyvalerolactone wherein the number average molecular weights of the polyvalerolactone and polyethylene glycol are in the ranges 500-10000 and 1000-8000, respectively. The disclosed hydrogels act as delivery matrices for therapeutic compounds. Pharmaceutically useful hydrogel compositions comprising biologically active agents conjugated to the block polymers are also disclosed.
Abstract translation: 公开了具有高于约30℃的凝胶化温度的温度敏感性水凝胶。这些水凝胶包含A-B型的二嵌段或三嵌段聚合物。 A-B-A或B-A-B，其中A嵌段包含疏水，可生物降解和不可溶胀的结构域，并且B嵌段包含亲水和可溶胀的结构域。 这种形成水凝胶的三嵌段聚合物的实例是聚戊内酯 - 聚乙二醇 - 聚戊内酯，其中聚戊内酯和聚乙二醇的数均分子量分别在500-10000和1000-8000的范围内。 所公开的水凝胶作为治疗化合物的递送基质。 还公开了包含与嵌段聚合物缀合的生物活性剂的药学上有用的水凝胶组合物。
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Patent Agency Ranking2.发明申请
公开(公告)号：WO2019018942A1
公开(公告)日：2019-01-31
申请号：PCT/CA2018/050914
申请日：2018-07-27
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： LI, Ren-Ke
Abstract: The present disclosure relates to a biocompatible, electrically conductive biomaterial capable of carrying the electrical potential of a cardiac impulse. The biomaterial comprises a conductive polymer and a biocompatible component. The conductive polymer comprising an aminomethoxybenzoic acid (AMBA) polymer. The present disclosure also relates to treatments, uses and devices using the biocompatible, electrically conductive biomaterial.
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3.发明申请
公开(公告)号：WO2014121378A1
公开(公告)日：2014-08-14
申请号：PCT/CA2014/000091
申请日：2014-02-04
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： LI, Ren-Ke
IPC: A61K50/00 , A61K31/785 , A61K31/787 , A61K9/10
CPC classification number: A61K31/787 , A61K9/0024 , A61K31/785 , A61K47/36 , A61K47/61 , A61K47/6435 , A61K47/6903 , A61L27/26 , A61L27/50 , A61L31/041 , A61L31/14 , A61L2400/06 , A61L2430/20 , C08G61/124 , C08G2261/128 , C08G2261/3221 , C08L89/06 , C08L5/08
Abstract: A biocompatible, electrically conductive biomaterial capable of earn carrying the electrical potential of a cardiac impulse and comprising (l) a conductive polymer such as polyaniline, polypyrrole or polythiophene, and (ii) a biocompatible component such as a polysaccharide, a protein, or a polypeptide, in particular chitosan or gelatin, is described. The material can take the form of a hydrogel, membrane, sheet or mesh. It can be used to restore or improve electrical impulse propagation across damaged tissue or scar region of the myocardium, in particular in the ti treatment of myocardial infarction and arrhythmia.
Abstract translation: 能够产生携带心脏脉冲电位的生物相容的导电生物材料，并且包括（l）导电聚合物如聚苯胺，聚吡咯或聚噻吩，和（ii）生物相容性成分如多糖，蛋白质或 多肽，特别是壳聚糖或明胶。 该材料可以采取水凝胶，膜，片或网的形式。 它可用于恢复或改善穿过受损组织或心肌瘢痕区域的电脉冲传播，特别是在心肌梗塞和心律失常的治疗中。
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公开(公告)号：EP2953651B1
公开(公告)日：2020-04-01
申请号：EP14748519.7
申请日：2014-02-04
Applicant: University Health Network
Inventor： LI, Ren-Ke
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5.发明公开
公开(公告)号：EP3658625A1
公开(公告)日：2020-06-03
申请号：EP18838499.4
申请日：2018-07-27
Applicant: University Health Network
Inventor： LI, Ren-Ke
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6.发明公开
公开(公告)号：EP2953651A1
公开(公告)日：2015-12-16
申请号：EP14748519.7
申请日：2014-02-04
Applicant: University Health Network
Inventor： LI, Ren-Ke
IPC: A61K50/00 , A61K31/785 , A61K31/787 , A61K9/10
CPC classification number: A61K31/787 , A61K9/0024 , A61K31/785 , A61K47/36 , A61K47/61 , A61K47/6435 , A61K47/6903 , A61L27/26 , A61L27/50 , A61L31/041 , A61L31/14 , A61L2400/06 , A61L2430/20 , C08G61/124 , C08G2261/128 , C08G2261/3221 , C08L89/06 , C08L5/08
Abstract: A biocompatible, electrically conductive biomaterial capable of earn carrying the electrical potential of a cardiac impulse and comprising (1) a conductive polymer such as polyaniline, polypyrrole or polythiophene, and (ii) a biocompatible component such as a polysaccharide, a protein, or a polypeptide, in particular chitosan or gelatin, is described. The material can take the form of a hydrogel, membrane, sheet or mesh. It can be used to restore or improve electrical impulse propagation across damaged tissue or scar region of the myocardium, in particular in the ti treatment of myocardial infarction and arrhythmia.
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