公开(公告)号：WO2023067577A1

公开(公告)日：2023-04-27

申请号：PCT/IB2022/060159

申请日：2022-10-21

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： HIRANO, Naoto ,  MURATA, Kenji ,  LY, Dalam ,  SAIJO, Hiroshi ,  MATSUNAGA, Yukiko

IPC: C07K14/74 ,  A61K31/7088 ,  A61K38/17 ,  A61K38/46 ,  A61P35/00 ,  A61P37/02 ,  C12N15/10 ,  C12N15/12

Abstract: The present disclosure is directed to methods of modifying an HLA-binding pocket in an HLA molecule in a subject. Some aspects are directed to HLA molecules comprising a modified HLA-binding pocket, where the HLA molecule has increased affinity for a peptide, e.g., an antigen. Other aspects are directed to compositions comprising the same and methods of using the same.

公开(公告)号：EP4419549A1

公开(公告)日：2024-08-28

申请号：EP22883097.2

申请日：2022-10-21

Applicant: University Health Network

Inventor： HIRANO, Naoto ,  MURATA, Kenji ,  LY, Dalam ,  SAIJO, Hiroshi ,  MATSUNAGA, Yukiko

IPC: C07K14/74 ,  A61K31/7088 ,  A61K38/17 ,  A61K38/46 ,  A61P35/00 ,  A61P37/02 ,  C12N15/10 ,  C12N15/12

CPC classification number: A61P35/00 ,  A61P37/02 ,  C07K14/70539 ,  A61K45/06 ,  A61K39/001184 ,  A61K39/001186 ,  A61K39/12 ,  A61K39/001188 ,  A61K39/001192 ,  C12N2740/1613420130101 ,  C12N2740/1623420130101