公开(公告)号：WO2022087719A1

公开(公告)日：2022-05-05

申请号：PCT/CA2021/051470

申请日：2021-10-19

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： HAROON, Nigil ,  NAKAMURA, Akihiro

IPC: A61K39/395 ,  A61K31/423 ,  A61P19/00 ,  C07D263/58 ,  C07K16/24

Abstract: Provided are methods of treating SpA, uses for treating SpA and compositions for treating SpA. The methods involve administering a MIF inhibitor to a subject in need thereof. The MIF inhibitor can be a compound or an anti-MIF antibody.

公开(公告)号：WO2017143430A1

公开(公告)日：2017-08-31

申请号：PCT/CA2017/000019

申请日：2017-01-31

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： KAPOOR, Mohit ,  NAKAMURA, Akihiro ,  RAMPERSAUD, Raja

IPC: A61K31/7088 ,  A61P19/00 ,  C12N15/113 ,  G01N33/48

CPC classification number: A61K31/7088 ,  A61K45/06 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/10 ,  A61K2300/00

Abstract: There is disclosed herein methods, uses and systems for the detection, diagnosis, prognosis, treatment or prevention of a disease or condition comprising cartilage degeneration in a subject that is in need thereof. The methods comprise the use, inhibition or measurement of at least one of miR-181 a-5p and miR-4454, in the subject.

Abstract translation: 本文公开了用于在有需要的受试者中检测，诊断，预后，治疗或预防包含软骨退化的疾病或病症的方法，用途和系统。 该方法包括在受试者中使用，抑制或测量miR-181a-5p和miR-4454中的至少一种。

公开(公告)号：EP4237002A1

公开(公告)日：2023-09-06

申请号：EP21884203.7

申请日：2021-10-19

Applicant: University Health Network

Inventor： HAROON, Nigil ,  NAKAMURA, Akihiro

IPC: A61K39/395 ,  A61K31/423 ,  A61P19/00 ,  C07D263/58 ,  C07K16/24