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    PEPT1DE-HLA COMPLEXES AND METHODS OF PRODUCING SAME
    1.
    发明申请
    PEPT1DE-HLA COMPLEXES AND METHODS OF PRODUCING SAME 审中-公开
    PEPT1DE-HLA复合物及其生产方法

    公开(公告)号：WO2017185169A1

    公开(公告)日：2017-11-02

    申请号：PCT/CA2017/000102

    申请日：2017-04-27

    Applicant: UNIVERSITY HEALTH NETWORK (UHN)

    Inventor： HIRANO, Naoto ,  NAKATSUGAWA, Munehide ,  RAHMAN, Muhammed Aashiq

    IPC: C07K14/74 ,  C12N15/12 ,  C12N5/10 ,  G01N33/53 ,  G01N33/569

    Abstract: There is provided herein, the use of mammalian derived HLA class I molecule for in vitro peptide exchange. For example, there is provided a method of producing an HLA class I molecule complexed to a pre-selected peptide comprising: (a) providing a mammalian derived HLA class 1 molecule complexed to an existing peptide; (b) incubating, in vitro, the HLA class I molecule complexed to the existing peptide with the pre-selected peptide, wherein the pre-selected peptide is at a concentration sufficient to replace the existing peptide to produce the HLA class I molecule complexed to the pre-selected peptide; and the HLA class I molecule comprises a1, a1, a2, a3 and β2m domains.

    Abstract translation: 本文提供了哺乳动物来源的HLA I类分子用于体外肽交换的用途。 例如，提供了产生与预先选择的肽复合的HLA I类分子的方法，其包括：（a）提供与现有肽复合的哺乳动物来源的HLA 1类分子; （b）在体外将与现有肽复合的HLA I类分子与预先选择的肽一起温育，其中预选肽的浓度足以替代现有的肽以产生与HLA复合的HLA I类分子 预先选择的肽; 并且HLA I类分子包含α1，α1，α2，α3和β2m结构域。

    PEPT1DE-HLA COMPLEXES AND METHODS OF PRODUCING SAME
    2.
    发明申请
    PEPT1DE-HLA COMPLEXES AND METHODS OF PRODUCING SAME 审中-公开

    公开(公告)号：WO2017185169A8

    公开(公告)日：2017-11-02

    申请号：PCT/CA2017/000102

    申请日：2017-04-27

    Applicant: UNIVERSITY HEALTH NETWORK (UHN)

    Inventor： HIRANO, Naoto ,  NAKATSUGAWA, Munehide ,  RAHMAN, Muhammed Aashiq ,  MURATA, Kenji

    IPC: C07K14/74 ,  C12N15/12 ,  C12N5/10 ,  G01N33/53 ,  G01N33/569

    Abstract: There is provided herein, the use of mammalian derived HLA class I molecule for in vitro peptide exchange. For example, there is provided a method of producing an HLA class I molecule complexed to a pre-selected peptide comprising: (a) providing a mammalian derived HLA class 1 molecule complexed to an existing peptide; (b) incubating, in vitro, the HLA class I molecule complexed to the existing peptide with the pre-selected peptide, wherein the pre-selected peptide is at a concentration sufficient to replace the existing peptide to produce the HLA class I molecule complexed to the pre-selected peptide; and the HLA class I molecule comprises a1, a1, a2, a3 and β2m domains.

    METHODS AND COMPOSITIONS FOR PRODUCING A CELL EXPRESSING A T CELL RECEPTOR
    3.
    发明申请
    METHODS AND COMPOSITIONS FOR PRODUCING A CELL EXPRESSING A T CELL RECEPTOR 审中-公开
    用于产生细胞表达T细胞受体的方法和组合物

    公开(公告)号：WO2015113140A1

    公开(公告)日：2015-08-06

    申请号：PCT/CA2015/000049

    申请日：2015-01-28

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： HIRANO, Naoto ,  NAKATSUGAWA, Munehide ,  OCHI, Toshiki

    IPC: C07K14/725 ,  A61K38/17 ,  C12N15/09 ,  C12N15/12 ,  C12N5/10 ,  C12P21/02

    CPC classification number: C07K14/7051 ,  A61K38/00 ,  C12N15/1037 ,  C12N15/1055

    Abstract: Provided is a method for determining a TCR polypeptide chain that can form a TCR specific for a peptide of interest. Also provided are methods and compositions for producing a cell expressing a T cell receptor (TCR) specific for a peptide of interest, methods and compositions for producing a TCR chain nucleic acid and/or pair of TCR chain polypeptides and/or nucleic acids encoding a TCR, a cell population comprising the cell harboring the nucleic acids encoding a TCR obtained by said method, and a method for treating a disorder comprising administering to the subject said cell population.

    Abstract translation: 本发明提供了一种确定可形成感兴趣肽特异性TCR的TCR多肽链的方法。 还提供了用于产生表达对感兴趣的肽特异性的T细胞受体（TCR）的细胞的方法和组合物，用于产生TCR链核酸和/或一对TCR链多肽和/或编码 TCR，包含携带编码通过所述方法获得的TCR的核酸的细胞的细胞群，以及用于治疗病症的方法，包括向受试者施用所述细胞群体。

    METHODS AND COMPOSITIONS FOR PRODUCING A CELL EXPRESSING A T CELL RECEPTOR
    6.
    发明公开
    METHODS AND COMPOSITIONS FOR PRODUCING A CELL EXPRESSING A T CELL RECEPTOR 审中-公开
    方法和组合物用于制造T细胞受体表达细胞

    公开(公告)号：EP3099708A1

    公开(公告)日：2016-12-07

    申请号：EP15744002.5

    申请日：2015-01-28

    Applicant: University Health Network

    Inventor： HIRANO, Naoto ,  NAKATSUGAWA, Munehide ,  OCHI, Toshiki

    IPC: C07K14/725 ,  A61K38/17 ,  C12N15/09 ,  C12N15/12 ,  C12N5/10 ,  C12P21/02

    CPC classification number: C07K14/7051 ,  A61K38/00 ,  C12N15/1037 ,  C12N15/1055

    Abstract: Provided is a method for determining a TCR polypeptide chain that can form a TCR specific for a peptide of interest. Also provided are methods and compositions for producing a cell expressing a T cell receptor (TCR) specific for a peptide of interest, methods and compositions for producing a TCR chain nucleic acid and/or pair of TCR chain polypeptides and/or nucleic acids encoding a TCR, a cell population comprising the cell harboring the nucleic acids encoding a TCR obtained by said method, and a method for treating a disorder comprising administering to the subject said cell population.

    Abstract translation: 提供了一种用于确定挖掘TCR多肽链确实能形成一个TCR特异性针对目的肽的方法。 这样提供了用于生产细胞中表达特异于感兴趣，方法和组合物的肽的T细胞受体（TCR）的制造TCR链多肽和/或编码的核酸的TCR链的核酸和/或对方法和组合物 TCR，细胞群包括将所述细胞携带编码由所述方法获得的TCR的核酸，以及用于治疗病症，其包括施用至所述受试者的方法，所述细胞群体。

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