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公开(公告)号：WO2021237352A1
公开(公告)日：2021-12-02
申请号：PCT/CA2021/050711
申请日：2021-05-26
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： PAIGE, Christopher J.
IPC: C12N15/867 , A61K38/20 , A61K39/00 , A61P25/00 , A61P37/04 , C07K14/54 , C12N15/24 , C12N5/10 , C12N7/01 , C12P21/02 , A61K2039/55527 , A61K2039/55538 , A61K2039/804 , A61K39/0011 , A61K39/39 , A61P35/02 , C07K14/5434 , C12N15/86 , C12N2740/16043
Abstract: Methods and compositions of whole cell vaccines for delivering immune modulatory molecules IL-12 and at least one of IL-21 and/or IL-18 to result in a therapeutic effect are disclosed. The methods and compositions use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia.
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公开(公告)号：EP3293266A1
公开(公告)日：2018-03-14
申请号：EP17184090.3
申请日：2008-05-05
Applicant: University Health Network
Inventor： MEDIN, Jeffrey A. , PAIGE, Christopher J.
IPC: C12N15/867 , A61K38/20 , A61K39/00 , A61K48/00 , A61P35/00 , A61P35/02 , A61P37/04 , C07K14/54 , C12N15/24 , C12N5/10 , C12P21/02
CPC classification number: A61K35/545 , A61K38/208 , A61K39/0011 , A61K48/005 , A61K2039/515 , A61K2039/53 , A61K2039/585 , C07K14/5434 , C07K2319/00 , C12N7/00 , C12N15/86 , C12N2710/16122 , C12N2730/10122 , C12N2740/13043 , C12N2740/15043 , C12N2740/15071 , C12N2740/16022 , C12N2800/40 , C12N2830/48 , C12N2830/60
Abstract: Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia
Abstract translation: 公开了用于递送免疫调节分子以产生治疗效果的组合物和方法。 该组合物和方法使用稳定整合慢病毒递送系统。 该方法可用于治疗和预防癌症如白血病
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公开(公告)号：EP4158038A1
公开(公告)日：2023-04-05
申请号：EP21812903.9
申请日：2021-05-26
Applicant: University Health Network
Inventor： PAIGE, Christopher J.
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