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1.发明申请METHODS FOR MAKING AND USING SINOATRIAL NODE-LIKE PACEMAKER CARDIOMYOCYTES AND VENTRICULAR-LIKE CARDIOMYOCYTES 审中-公开方法制备和使用中枢神经节细胞样细胞核心脏和心脏样细胞核细胞
公开(公告)号：WO2016131137A1
公开(公告)日：2016-08-25
申请号：PCT/CA2016/050142
申请日：2016-02-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： KELLER, Gordon , PROTZE, Stephanie
CPC classification number: A61K35/34 , C12N5/0657 , C12N5/10 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/165 , C12N2501/385 , C12N2501/727 , C12N2501/999 , C12N2506/02 , C12N2506/45
Abstract: Provided are methods for producing compositions comprising a population of cardiomyocytes enriched for or substantially devoid of sinoatrial node-like pacemaker cardiomyocytes (SANLCM) from human pluripotent stem cells (hPSCs), and methods of use thereof.
Abstract translation: 提供了用于生产组合物的方法，所述组合物包含从人多能干细胞（hPSC）富集或基本上不含窦房结起搏器心脏起搏器心肌细胞（SANLCM）的心肌细胞群及其使用方法。
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2.发明申请
公开(公告)号：WO2018098597A1
公开(公告)日：2018-06-07
申请号：PCT/CA2017/051460
申请日：2017-12-04
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： KELLER, Gordon , PROTZE, Stephanie , LEE, Jee Hoon
Abstract: Methods are disclosed for producing populations of cardiomyocytes from pluripotent stem cells. Populations may be enriched for either atrial or ventricular cardiomyocytes and the resulting ventricular population may be essentially free of pacemaker cells. The method includes incubating pluripotent stem cells in a suitable medium with a BMP component, and an activin component, the amounts of activin may be varied to enrich for either atrial or ventricular cardiomyocytes. The enriched populations, as well as methods of using the same to treat patients in need of cardiac repair are disclosed.
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3.发明公开
公开(公告)号：EP3548608A1
公开(公告)日：2019-10-09
申请号：EP17875726.6
申请日：2017-12-04
Applicant: University Health Network
Inventor： KELLER, Gordon , PROTZE, Stephanie , LEE, Jee Hoon
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4.发明公开METHODS FOR MAKING AND USING SINOATRIAL NODE-LIKE PACEMAKER CARDIOMYOCYTES AND VENTRICULAR-LIKE CARDIOMYOCYTES 审中-公开制备和使用SINOATRIAL NODE样PACEMAKER心肌细胞和心室样心肌细胞的方法
公开(公告)号：EP3259348A1
公开(公告)日：2017-12-27
申请号：EP16751855.4
申请日：2016-02-17
Applicant: University Health Network
Inventor： KELLER, Gordon , PROTZE, Stephanie
CPC classification number: A61K35/34 , C12N5/0657 , C12N5/10 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/165 , C12N2501/385 , C12N2501/727 , C12N2501/999 , C12N2506/02 , C12N2506/45
Abstract: Provided are methods for producing compositions comprising a population of cardiomyocytes enriched for or substantially devoid of sinoatrial node-like pacemaker cardiomyocytes (SANLCM) from human pluripotent stem cells (hPSCs), and methods of use thereof.
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