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1.发明申请DEVICES AND PROCESSES FOR CHERENKOV-ACTIVATED NUCLEAR-TARGETED PHOTODYNAMIC THERAPY 审中-公开CHERENKOV激活的核靶光动力学疗法的装置和过程
公开(公告)号：WO2017197531A1
公开(公告)日：2017-11-23
申请号：PCT/CA2017/050614
申请日：2017-05-19
Inventor： WILSON, Brian , ALLEN, Christine
Abstract: Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensitizing material that is located in the nucleus of cells of the target volume.
Abstract translation: Cherenkov激活的核靶向光动力疗法的设备，材料，化合物，系统和方法涉及在目标体积的组织内产生切伦科夫光并使用该光激活位于目标体内的光敏材料 在目标体积的细胞核中。
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2.发明申请
公开(公告)号：WO2008028298A1
公开(公告)日：2008-03-13
申请号：PCT/CA2007/001581
申请日：2007-09-06
Applicant: UNIVERSITY HEALTH NETWORK , WILSON, Brian , BOGAARDS, Arjen
Inventor： WILSON, Brian , BOGAARDS, Arjen
CPC classification number: G01N21/6456
Abstract: Various embodiments of methods and systems are described herein for the acquisition and quantification of fluorescence or luminescence signals from a region of interest of an object. The quantification of the acquired signals includes performing at least one ratiometric operation to correct these signals for artifacts due to various factors.
Abstract translation: 本文描述了用于从物体的感兴趣区域获取和定量荧光或发光信号的方法和系统的各种实施例。 所获取的信号的量化包括执行至少一个比例操作以由于各种因素来校正这些信号的伪像。
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Patent Agency Ranking
公开(公告)号：WO2014117253A1
公开(公告)日：2014-08-07
申请号：PCT/CA2014/000062
申请日：2014-01-28
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： GANG, Zheng , HUYNH, Elizabeth , NG, Kenneth , SHAKIBA, Mojdeh , WEERSINK, Robert , WILSON, Brian
CPC classification number: A61K49/227 , A61K49/0036 , A61K49/0052 , A61K49/0084 , A61K49/221
Abstract: There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.
Abstract translation: 本文提供了具有包含饱和第一磷脂和不超过约15摩尔％的与J-骨料形成染料共价缀合的第二磷脂的双层的纳米囊。
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4.发明申请BIOPSY DEVICE AND METHOD FOR OBTAINING A TOMOGRAM OF A TISSUE VOLUME USING SAME 审中-公开用于获得组织体积的TOMOGRAM的BIOPSY装置和方法
公开(公告)号：WO2015010213A1
公开(公告)日：2015-01-29
申请号：PCT/CA2014/050708
申请日：2014-07-25
Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY , UNIVERSITY HEALTH NETWORK , POLYVALOR, LIMITED PARTNERSHIP
Inventor： LEBLOND, Frédéric , WILSON, Brian , GOYETTE, Andréanne , PICHETTE, Julien , PETRECCA, Kevin , BOUDOUX, Caroline , MADORE, Wendy-julie , STRUPLER, Mathias
CPC classification number: A61B10/04 , A61B1/07 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/14546 , A61B5/14556 , A61B5/1459 , A61B10/0275 , A61B10/0283 , A61B2010/045
Abstract: The biopsy device generally comprises: a cannula body having a longitudinal axis and a probing region extending along the longitudinal axis, the probing region having a sample receiving window defined therein for receiving a sample of a surrounding tissue when performing a biopsy; and a plurality of optical fibers mounted along an exterior portion of the cannula body, each of the plurality of optical fibers having a fiber end in the probing region of the cannula body, at least one of the plurality of optical fibers being adapted to illuminate the surrounding tissue with an optical signal generated by the at least one light generator and at least one of the plurality of optical fibers being adapted to detect an optical signal response with the at least one light detector, the optical signal response being caused by the propagation of the optical signal in the surrounding tissue.
Abstract translation: 活检装置通常包括：具有纵向轴线和沿着纵向轴线延伸的探测区域的套管主体，探测区域具有限定在其中的样本接收窗口，用于在进行活检时接收周围组织的样本; 以及沿着所述套管主体的外部部分安装的多个光纤，所述多个光纤中的每一个在所述套管本体的探测区域中具有光纤端，所述多个光纤中的至少一个适于照亮所述光纤 具有由所述至少一个光发生器产生的光学信号的周围组织，并且所述多个光纤中的至少一个适于利用所述至少一个光检测器检测光信号响应，所述光信号响应是由所述至少一个光发射器的传播引起的 周围组织中的光信号。
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公开(公告)号：EP3458155A1
公开(公告)日：2019-03-27
申请号：EP17798468.9
申请日：2017-05-19
Inventor： WILSON, Brian , ALLEN, Christine
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6.发明公开BIOPSY DEVICE AND METHOD FOR OBTAINING A TOMOGRAM OF A TISSUE VOLUME USING SAME 审中-公开活检装置及其制造方法组织体积一层形象，
公开(公告)号：EP3024399A1
公开(公告)日：2016-06-01
申请号：EP14829792.2
申请日：2014-07-25
Applicant: The Royal Institution for the Advancement of Learning / McGill University , University Health Network , Polyvalor, Limited Partnership
Inventor： LEBLOND, Frédéric , WILSON, Brian , GOYETTE, Andréanne , PICHETTE, Julien , PETRECCA, Kevin , BOUDOUX, Caroline , MADORE, Wendy-julie , STRUPLER, Mathias
CPC classification number: A61B10/04 , A61B1/07 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/14546 , A61B5/14556 , A61B5/1459 , A61B10/0275 , A61B10/0283 , A61B2010/045
Abstract: The biopsy device generally comprises: a cannula body having a longitudinal axis and a probing region extending along the longitudinal axis, the probing region having a sample receiving window defined therein for receiving a sample of a surrounding tissue when performing a biopsy; and a plurality of optical fibers mounted along an exterior portion of the cannula body, each of the plurality of optical fibers having a fiber end in the probing region of the cannula body, at least one of the plurality of optical fibers being adapted to illuminate the surrounding tissue with an optical signal generated by the at least one light generator and at least one of the plurality of optical fibers being adapted to detect an optical signal response with the at least one light detector, the optical signal response being caused by the propagation of the optical signal in the surrounding tissue.
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公开(公告)号：EP2950827A1
公开(公告)日：2015-12-09
申请号：EP14745446.6
申请日：2014-01-28
Applicant: University Health Network
Inventor： GANG, Zheng , HUYNH, Elizabeth , NG, Kenneth , SHAKIBA, Mojdeh , WEERSINK, Robert , WILSON, Brian
CPC classification number: A61K49/227 , A61K49/0036 , A61K49/0052 , A61K49/0084 , A61K49/221
Abstract: There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.
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