公开(公告)号：WO2021179096A

公开(公告)日：2021-09-16

申请号：PCT/CA2021/050343

申请日：2021-03-15

Applicant: UNIVERSITY HEALTH NETWORK [CA]/[CA]

Inventor： SAGE, Andrew ,  VALERO, Jerome ,  DEL SORBO, Lorenzo ,  CYPEL, Marcelo ,  WANG, Bo ,  KESHAVJEE, Shafique

IPC: G01N33/48 ,  G01N33/53 ,  G01N33/543 ,  G16H50/30

Abstract: Methods and kits for screening, diagnosing, detecting or predicting a patient outcome/risk in a patient with a respiratory illness, the method comprising: a. obtaining a sample obtained from the patient; b. quantitatively measuring in the sample a polypeptide level of one or more biomarkers selected from: IL-6, CXCL8, IL-10, IL-1RA, IL-2, IL-4, IL-7, IL-9, IL-13, IL-17, IFN-g, IP-10, MCP-1, G-CSF, GM-CSF, FGF-basic, SCGF-β, GRO-α, MIP1-α, MIP1-β, CK-18, PDGF-bb, caspase 3, HMGB-1, TNF α, VEGF, sTNFR1 and sTREM1; and c. i) comparing the level of the one or more biomarkers in the sample with a control or cut-off level, wherein the differential level is indicative of patient outcome risk; or ii) using the polypeptide level of several of the biomarkers in combination, as inputs for an algebraic calculation or machine learning model of patient outcome risk.