公开(公告)号：US20230404765A1

公开(公告)日：2023-12-21

申请号：US18251984

申请日：2021-10-07

Applicant: UNIVERSITY OF CONNECTICUT

Inventor： Thanh Duc Nguyen ,  Thi Tra Nguyen

IPC: A61F2/38 ,  A61L27/26 ,  A61L27/36

CPC classification number: A61F2/38 ,  A61L27/26 ,  A61L27/3654 ,  A61F2002/2864

Abstract: Methods and systems of osteoarthritis treatment. One method includes providing a cartilage hydrogel, the cartilage hydrogel including piezoelectric nano-fibers of Poly-L-lactide (PLLA). The method also includes injecting the cartilage hydrogel into a cartilage defect. The method also includes applying an ultrasonic treatment to the cartilage defect. The method also includes, in response to applying the ultrasonic treatment to the cartilage defect, converting a mechanical impact of the ultrasonic treatment into an electrical charge from the piezoelectric nano-fibers of PLLA and providing, in response to the electrical charge from the piezoelectric nano-fibers of PLLA, chondrogenesis differentiation for cartilage regeneration for the cartilage defect.

公开(公告)号：US20220176171A1

公开(公告)日：2022-06-09

申请号：US17541658

申请日：2021-12-03

Applicant: University of Connecticut

Inventor： Thanh Nguyen ,  Eli Curry ,  Thinh T. Le ,  Thi Tra Nguyen

IPC: A62B23/02 ,  A61L2/10 ,  D04H1/728

Abstract: A facepiece respirator configured to be worn by a user. The facepiece respirator includes including a first layer and a second layer coupled to the first layer. The first layer is positionable adjacent the user. A filtering layer is positioned between the first and second layer, and the filtering layer includes a piezoelectric film.