公开(公告)号：US09839636B2

公开(公告)日：2017-12-12

申请号：US15481542

申请日：2017-04-07

Applicant: UNIVERSITY OF CONNECTICUT

Inventor： Matthew Kyle Hadden ,  Upasana Banerjee

IPC: A61K31/496

CPC classification number: A61K31/496 ,  C07D405/12 ,  C07D405/14

Abstract: Disclosed herein are analogues of itraconazole that are both angiogenesis and hedgehog signaling pathway inhibitors. The compounds are expected to be useful in the treatment of cancer, particularly cancers that are dependent upon the hedgehog signaling pathway such as basal cell carcinoma and medulloblastoma.

公开(公告)号：US09650365B2

公开(公告)日：2017-05-16

申请号：US15225021

申请日：2016-08-01

Applicant: UNIVERSITY OF CONNECTICUT

Inventor： Matthew Kyle Hadden ,  Upasana Banerjee

IPC: C07D405/14 ,  C07D405/12

CPC classification number: A61K31/496 ,  C07D405/12 ,  C07D405/14

Abstract: Disclosed herein are analogs of itraconazole that are both angiogenesis and hedgehog signaling pathway inhibitors. The compounds are expected to be useful in the treatment of cancer, particularly cancers that are dependent upon the hedgehog signaling pathway such as basal cell carcinoma and medulloblastoma.