公开(公告)号：WO1990003163A1

公开(公告)日：1990-04-05

申请号：PCT/US1989003677

申请日：1989-08-29

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  BODOR, Nicholas, S. ,  LOFTSSON, Thorsteinn

IPC: A61K09/06

CPC classification number: A61K47/12 ,  A61K47/186

Abstract: A composition and method for enhancing permeability of topical drugs wherein the agent which enhances the permeability of the drug is selected from the group consisting of (1) a choline ester having the formula: [CH3(CH2)n-COOCH2CH2N+(CH3)3]X- or [CH¿3?(CH2)mCH=CH(CH2)n-COOCH2CH2N?+(CH¿3)3]X-, wherein m and n are integers in the range of from 0 to 30 and X- is a pharmaceutically acceptable anion and (2) a mixture of the choline ester and an acid having the formula: CH¿3?(CH2)n-COOH or CH3(CH2)mCH=CH(CH2)n-COOH or a pharmaceutically acceptable salt thereof.