公开(公告)号：WO2015120272A1

公开(公告)日：2015-08-13

申请号：PCT/US2015/014818

申请日：2015-02-06

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： RIMER, Jeffrey, D. ,  ASPLIN, John

IPC: A61K31/194 ,  A61K31/19 ,  A61P13/12

CPC classification number: A61K31/194

Abstract: In an embodiment of the present disclosure, there is provided a composition for inhibiting calcium oxalate crystal growth. In an embodiment of the present disclosure, there is provided a composition for inhibiting calcium phosphate crystal growth. In some embodiments, such a composition comprises at least one citrate derivative of an organic acid and at least one pharmaceutically acceptable carrier. In another embodiment, the present disclosure relates to a method of controlling calcium oxalate crystal growth in a subject in need thereof. Such a method comprises administering to the subject an effective amount of the aforementioned composition. In another embodiment, the present disclosure pertains to a method of treating kidney stone disorder. Such a method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition. In yet another embodiment, the present disclosure relates to a method of treating calcium oxalate stone disease. In an embodiment, the method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition.

Abstract translation: 在本公开的一个实施方案中，提供了用于抑制草酸钙晶体生长的组合物。 在本公开的一个实施方案中，提供了一种抑制磷酸钙晶体生长的组合物。 在一些实施方案中，这样的组合物包含至少一种有机酸的柠檬酸盐衍生物和至少一种药学上可接受的载体。 在另一个实施方案中，本公开内容涉及在有需要的受试者中控制草酸钙晶体生长的方法。 这种方法包括向受试者施用有效量的上述组合物。 在另一个实施方案中，本公开涉及治疗肾结石病症的方法。 这种方法包括向有需要的受试者施用治疗有效量的上述组合物。 在另一个实施方案中，本公开涉及治疗草酸钙石病的方法。 在一个实施方案中，该方法包括向有需要的受试者施用治疗有效量的上述组合物。