公开(公告)号：US20180243340A1

公开(公告)日：2018-08-30

申请号：US15753662

申请日：2016-08-23

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： Navin Varadarajan ,  Gabrielle Romain ,  Laurence Cooper ,  Harjcct Singh

IPC: A61K35/17 ,  C12N5/0783 ,  G01N33/50 ,  C07K19/00

CPC classification number: A61K35/17 ,  A61P35/00 ,  C07K19/00 ,  C07K2319/03 ,  C12N5/0636 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/53 ,  C12N2501/599 ,  G01N33/502

Abstract: In some embodiments, the present disclosure pertains to a method of enhancing chimeric antigen receptor expressing T cell function. In some embodiments, the method comprises activating the chimeric antigen receptor expressing T cells. In some embodiments, the method further comprises determining the differential expression of at least one molecule on the chimeric antigen receptor T cells. In some embodiments, the method comprises targeting the at least one molecule. In some embodiments, the present disclosure pertains to a method of treating a tumor in a subject in need thereof. In some embodiments, the method comprises administering to the subject an infusion of chimeric antigen receptor expressing T cells. In some embodiments, the method further comprises determining the differential expression of at least one molecule on the chimeric antigen receptor T cells. In some embodiments, the method comprises targeting the at least one molecule, wherein the molecule is differentially expressed upon activation of the chimeric antigen receptor expressing T cells.