公开(公告)号：WO1992014752A1

公开(公告)日：1992-09-03

申请号：PCT/CA1992000069

申请日：1992-02-21

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  LAWMAN, Michael, J., P. ,  OHMANN, Helle, Bielefeldt ,  ATTAH-POKU, Samuel, K. ,  HEISE-QUALTIERE, Janette

IPC: C07K07/08

CPC classification number: C07K14/53 ,  A61K38/00 ,  C07K16/243 ,  C07K2317/34

Abstract: The present invention relates to novel primitive cell colony stimulating factors (PC-CSFs) and active fragments thereof, derived from non-adherent (NA) bone marrow cells. These factors are useful for treating disorders of the hematopoietic system. Antibodies directed against epitopes specific for PC-CSF can be used to purify PC-CSF, as well as for diagnosis of hematopoietic disorders.

Abstract translation: 本发明涉及源于非粘附（NA）骨髓细胞的新颖的原始细胞集落刺激因子（PC-CSF）及其活性片段。 这些因素对于治疗造血系统的病症是有用的。 针对PC-CSF特异性表位的抗体可用于纯化PC-CSF，以及诊断造血障碍。