公开(公告)号：US20240124595A1

公开(公告)日：2024-04-18

申请号：US18277831

申请日：2022-02-25

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Maruti Uppalapati ,  Ekaterina Dadachova

IPC: C07K16/28 ,  A61K51/10 ,  A61P35/00 ,  G01N33/574

CPC classification number: C07K16/2863 ,  A61K51/103 ,  A61P35/00 ,  G01N33/57407 ,  G01N33/57492 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/92

Abstract: The disclosure relates to antibodies that bind human, murine, and canine IGF2R, and methods of using said antibodies. Provided herein are antibodies having specific CDRs identified herein, including functional variants of specific variable domains and IgGs having the specified CDR sequences, and immunoconjugates of said antibodies and uses thereof. Also provided herein are compositions and kits comprising said antibodies, and methods and uses of said antibodies, immunoconjugates, compositions, and kits. Also provided herein are the use of said antibodies for radioimmunotherapy (RIT) for cancer including osteosarcoma.