公开(公告)号：US20230330020A1

公开(公告)日：2023-10-19

申请号：US18036397

申请日：2020-11-13

Applicant: UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA

Inventor： Shu ZHU ,  Yucai WANG ,  Guorong ZHANG ,  Qin WANG ,  Wanyin TAO ,  Wei JIANG

IPC: A61K9/127 ,  A61K47/34 ,  A61K47/26 ,  A61K31/43 ,  A61K38/14 ,  A61K31/7036

CPC classification number: A61K9/1272 ,  A61K9/1277 ,  A61K47/34 ,  A61K47/26 ,  A61K31/43 ,  A61K38/14 ,  A61K31/7036

Abstract: An orally administered antibiotic encapsulated in nanospheres, as well as its preparation method and application. The antibiotic encapsulated in the nanospheres includes an antibiotic and a degradable biocompatible polymer that encapsulates the antibiotic, wherein biocompatible polymer includes monosaccharide-modified poly (ethylene glycol)-poly(lactic-co-glycolic acid) (PEG-PLGA), which can significantly improves the damage caused by oral antibiotics to the intestinal microbiota, avoids destruction of the microbial community, thereby preventing chronic diseases associated with intestinal microbial imbalance, and a good biocompatibility and long-term safety.