公开(公告)号：WO1994008048A1

公开(公告)日：1994-04-14

申请号：PCT/US1993009136

申请日：1993-09-29

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  INSERM

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  INSERM ,  LALOUEL, Jean-Marc ,  JEUNEMAITRE, Xavier ,  LIFTON, Richard, P. ,  SOUBRIER, Florent ,  KOTELEVTSEV, Youri ,  CORVOL, Pierre

IPC: C12Q01/68

CPC classification number: C12Q1/6827 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172 ,  Y10T436/143333

Abstract: The association of molecular variants of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to hypertension, especially essential hypertension and pregnancy-induced hypertension (preeclampsia).

Abstract translation: 公开了血管紧张素原基因的分子变体与人高血压的关联。 确定这种关联可以筛选出具有高血压倾向的人，特别是原发性高血压和妊娠高血压（先兆子痫）。

公开(公告)号：WO1997032874A1

公开(公告)日：1997-09-12

申请号：PCT/FR1997000367

申请日：1997-03-03

Applicant: ROUSSEL UCLAF ,  INSERM ,  DEPREZ, Pierre ,  DUMAS, Jacques ,  FOURNIE-ZALUSKI, Marie-Claude ,  GUILLAUME, Jacques ,  ROQUES, Bernard, Pierre

Inventor： ROUSSEL UCLAF ,  INSERM

IPC: C07D405/12

CPC classification number: C07D257/04 ,  C07C323/60 ,  C07D209/18 ,  C07D333/24 ,  C07D405/12

Abstract: Products of formula (I), wherein n is 0 or 1, R1 is particularly phenyl or biphenyl optionally substituted particularly by benzyloxy, dioxol or halogen, R2 is particularly hydrogen or methyl substituted particularly by indolyl, phenylthio or phenyl, which may in turn be substituted, and A is carboxy, tetrazolyl or substituted alkyl, as well as all salts and isomers thereof, are disclosed.

Abstract translation: 式（I）的产物，其中n为0或1，R 1特别是苯基或联苯，特别是被苄氧基，二氧杂环戊烯或卤素任选取代，R 2特别是氢或被吲哚基，苯硫基或苯基取代的甲基， 并且A是羧基，四唑基或取代的烷基，以及其所有的盐和异构体。

公开(公告)号：WO1997032897A1

公开(公告)日：1997-09-12

申请号：PCT/FR1997000368

申请日：1997-03-03

Applicant: ROUSSEL UCLAF ,  INSERM ,  DUMAS, Jacques ,  ROQUES, Bernard, Pierre

Inventor： ROUSSEL UCLAF ,  INSERM

IPC: C07K14/575

CPC classification number: C07K14/57536

Abstract: Products of formula (IA), wherein X is particularly a (2,3) H-propionyl radical, the use thereof in an endothelin-converting enzyme inhibitor identification test, and the rapid determination of the inhibitory activity of such compounds, are disclosed. When systematically applied, the test enables a large number of assays to be carried out.

Abstract translation: 式（IA）的产物，其中X特别是（2,3）3H-丙酰基，其用于内皮素转化酶抑制剂鉴定试验中，并且快速测定这些化合物的抑制活性， 被披露。 当系统应用时，该测试可以进行大量测定。