公开(公告)号：WO2020168068A1

公开(公告)日：2020-08-20

申请号：PCT/US2020/018098

申请日：2020-02-13

Applicant: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE

Inventor： MAY, Victor ,  BREWER, Matthias ,  LI, Jianing

IPC: A61K31/404 ,  A61K31/166 ,  A61K31/407

Abstract: The invention relates to compounds that demonstrate efficacy in blocking PACAP receptors ( e.g . PAC1) and associated methods of treating neurological diseases or disorders using the disclosed compounds. The neurological diseases or disorders include, but are not limited to, stress-related diseases ( e.g . chronic stress, post-traumatic stress disorder (PTSD), anxiety, or general anxiety disorder), pain-related diseases ( e.g . chronic pain, primary headache disorders, or migraines), or addiction ( e.g . addiction to a substance ( e.g . addiction to cocaine, amphetamines, methamphetamine, methylphenidate, nicotine, alcohol, prescription medication, marijuana, tobacco, or an opioid selected from heroin, fentanyl, codeine, hydrocodone, morphine, oxycodone, hydromorphone, and methadone)).

公开(公告)号：WO2023059914A1

公开(公告)日：2023-04-13

申请号：PCT/US2022/046113

申请日：2022-10-07

Applicant: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE

Inventor： MAY, Victor ,  BREWER, Matthias ,  LI, Jianing

IPC: A61K31/475 ,  A61K31/404 ,  A61K31/47 ,  C07D209/04

Abstract: The disclosure relates to compounds that demonstrate efficacy in blocking PACAP receptors (e.g. PAC1) and associated methods of treating neurological diseases or disorders using the disclosed compounds. The neurological diseases or disorders include, but are not limited to, stress-related diseases (e.g. chronic stress, post-traumatic stress disorder (PTSD), panic disorder, anxiety, or general anxiety disorder), pain-related diseases (e.g. chronic pain, primary headache disorders, or migraines), or addiction (e.g. addiction to a substance (e.g. addiction to cocaine, amphetamines, methamphetamine, methylphenidate, nicotine, alcohol, prescription medication, marijuana, tobacco, or an opioid selected from heroin, fentanyl, codeine, hydrocodone, morphine, oxycodone, hydromorphone, and methadone)).

公开(公告)号：WO2021247566A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/035238

申请日：2021-06-01

Applicant: UNIVERSITY OF VERMONT

Inventor： SCHNEEBELI, Severin T. ,  LI, Jianing ,  SHARAFI, Mona

IPC: B01J20/22 ,  C07C63/331 ,  C09D5/00 ,  C07C45/46 ,  C07C51/29 ,  C07C67/08 ,  C07D201/00

Abstract: The present application is directed to a nanocage of Formula (I): wherein A and R are as described herein. The present application is also directed to a process for preparation of a nanocage of Formula (I). Methods of utilizing the nanocage for detecting an analyte in a fluid and for functionalizing a polymer are also described.