公开(公告)号：WO1996022385A1

公开(公告)日：1996-07-25

申请号：PCT/US1996000787

申请日：1996-01-19

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  LOEB, Lawrence, A. ,  KIM, Baek

IPC: C12Q01/18

CPC classification number: G01N33/502 ,  C12N9/1276 ,  C12Q1/18 ,  C12Q1/48 ,  G01N33/5008

Abstract: Methods and compositions related to hepatitis are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to inhibit reverse transcriptase of hepatitis virus ("HV RT"). Active HV RT mutants may be detected by the disclosed methods. The present invention also discloses methods for screening for compounds that inhibit HV RT obtained from an individual patient.

Abstract translation: 公开了与肝炎相关的方法和组合物。 使用本发明的方法，可以筛选候选化合物抑制肝炎病毒逆转录酶（“HV RT”）的能力。 活性HV RT突变体可以通过所公开的方法检测。 本发明还公开了筛选从个体患者获得的抑制HV RT的化合物的方法。

公开(公告)号：WO1995022622A1

公开(公告)日：1995-08-24

申请号：PCT/US1995002074

申请日：1995-02-16

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  LOEB, Lawrence, A. ,  KIM, Baek

IPC: C12Q01/48

CPC classification number: C12N9/1276 ,  C12N15/1058 ,  C12Q1/48

Abstract: Methods and compositions related to AIDS are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to inhibit reverse transcriptase of human immunodeficiency virus ("HIV RT"). Active HIV RT mutants may be detected by the disclosed methods. The present invention also discloses methods for screening for compounds that inhibit HIV RT obtained from an individual patient. In another aspect, methods for testing the biological effectiveness of candidate compounds for the inhibition of the HIV RT in vivo are disclosed.

Abstract translation: 披露与艾滋病有关的方法和成分。 使用本发明的方法，可以筛选候选化合物以抑制人类免疫缺陷病毒（“HIV RT”）的逆转录酶的能力。 可以通过所公开的方法检测活性HIV RT突变体。 本发明还公开了筛选从个体患者获得的抑制HIV RT的化合物的方法。 另一方面，公开了用于测试候选化合物在体内抑制HIV RT的生物学效力的方法。