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    METHODS FOR TREATING MIDDLE AND INNER EAR DISORDERS
    5.
    发明申请
    METHODS FOR TREATING MIDDLE AND INNER EAR DISORDERS 审中-公开
    用于治疗中度和内脏疾病的方法

    公开(公告)号：WO1997038698A1

    公开(公告)日：1997-10-23

    申请号：PCT/US1997006507

    申请日：1997-04-18

    Applicant: UNIVERSITY TECHNOLOGY CORPORATION ,  MANNING, Mark, C. ,  SHEFTER, Eli ,  HART, Michael, J.

    Inventor： UNIVERSITY TECHNOLOGY CORPORATION

    IPC: A61K31/715

    CPC classification number: A61K9/0046 ,  A61K31/7036 ,  A61K47/36

    Abstract: Provided are methods to deliver drugs to the middle or inner ear of a mammal in need of such drug comprising inserting a composition comprising a biocompatible polymer and at least one pharmacologically active agent. More particularly, the invention relates to a method for treating Meniere's disease using a composition of hyaluronic acid and gentamicin.

    Abstract translation: 提供了将药物递送到需要这种药物的哺乳动物的中耳或内耳的方法，包括插入包含生物相容性聚合物和至少一种药理活性剂的组合物。 更具体地，本发明涉及使用透明质酸和庆大霉素组合物治疗梅尼埃病的方法。

    APPARATUS AND METHODS FOR ANALYZING BODY SOUNDS
    9.
    发明申请
    APPARATUS AND METHODS FOR ANALYZING BODY SOUNDS 审中-公开
    用于分析身体声音的装置和方法

    公开(公告)号：WO1998020792A1

    公开(公告)日：1998-05-22

    申请号：PCT/US1997021185

    申请日：1997-11-13

    Applicant: UNIVERSITY TECHNOLOGY CORPORATION

    Inventor： UNIVERSITY TECHNOLOGY CORPORATION ,  SHAPIRO, Joseph, Isaac ,  WEINBERGER, Howard, David

    IPC: A61B05/02

    CPC classification number: A61B7/04 ,  A61B5/0456 ,  A61B5/7203 ,  A61B5/7257 ,  A61B5/726 ,  A61B7/003

    Abstract: This invention is an apparatus and method for assisting an operator to diagnose physical conditions in a patient by collecting and analyzing cyclical body sounds such as heart beat, peripheral vessel sounds, or breath sounds. Several cycles of data are collected by sound detector (12) and digitized by an analog to digital converter (28). Each cycle is converted to the frequency domain (102), and phase fixed (104). Then all of the frequency converted and phase fixed cycles are signal averaged (106) together, and the results displayed (108) to the operator. The cycles may be sorted according to respiratory cycle (204, 304, 404), and averaged (210, 310, 410) in two groups. The cycles may be gated according to the patients ECG (206). The apparatus may also suggest diagnoses (218, 318, 418) or further maneuvers (214) to be performed.

    Abstract translation: 本发明是一种用于通过收集和分析周期性身体声音（例如心跳，外周血管声音或呼吸音）来帮助操作者诊断患者身体状况的装置和方法。 由声音检测器（12）收集几个数据周期，并由模数转换器（28）数字化。 每个周期被转换为频域（102），相位固定（104）。 然后将所有频率转换和相位固定周期信号平均化（106），结果显示（108）给操作员。 循环可以根据呼吸周期（204,304,404）和平均值（210,310,410）进行分类。 循环可以根据患者心电图门控（206）。 该装置还可以建议要执行的诊断（218,318,418）或进一步的操纵（214）。

    BIOCOMPATIBLE CATIONIC DETERGENTS AND USES THEREFOR
    10.
    发明申请
    BIOCOMPATIBLE CATIONIC DETERGENTS AND USES THEREFOR 审中-公开
    生物化学阳离子洗涤剂及其用途

    公开(公告)号：WO1998010649A1

    公开(公告)日：1998-03-19

    申请号：PCT/US1997016181

    申请日：1997-09-11

    Applicant: UNIVERSITY TECHNOLOGY CORPORATION

    Inventor： UNIVERSITY TECHNOLOGY CORPORATION ,  SHEFTER, Eli ,  RUTH, James, A. ,  MEYER, Jeffery, D. ,  MANNING, Mark, C. ,  KROLL, David, J. ,  CLAFFEY, David, J.

    IPC: A01N37/12

    CPC classification number: B82Y5/00 ,  A61K9/0073 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5123 ,  A61K9/5153 ,  A61K9/5192 ,  A61K38/046 ,  A61K38/09 ,  A61K38/10 ,  A61K38/11 ,  A61K38/27 ,  A61K38/28 ,  A61K38/57 ,  A61K47/183 ,  A61K47/28 ,  A61K47/541 ,  A61K47/6927 ,  B01F3/0092 ,  B01F2003/0064 ,  C07J41/0055 ,  C07K1/32 ,  Y02P20/544

    Abstract: Provided is a method for preparing a true, homogeneous solution of a pharmaceutical substance dissolved in an organic solvent in which the pharmaceutical substance is not normally soluble. Solubilization is obtained by forming a hydrophobic ion pair complex involving the pharmaceutical substance and an amphiphilic material. The resulting organic solution may be further processed to prepare pharmaceutical powders. A biodegradable polymer may be co-dissolved with the pharmaceutical substance and the amphiphilic material and may be incorporated into a pharmaceutical powder. A preferred method for preparing pharmaceutical powders is to subject the organic solution to gas antisolvent precipitation using a supercritical gas antisolvent such as carbon dioxide. Also provided is a method for making hollow particles having a fiber-like shape which would provide enhanced retention time in the stomach if ingested by a human or animal host. Further provided are novel biocompatible cationic surfactants and uses therefor, including the delivery, in vitro and in vivo, of nucleic acids into cells to transform the cells.

    Abstract translation: 提供了制备溶解在药物通常不溶于其中的有机溶剂中的药物的真实均匀溶液的方法。 通过形成涉及药物物质和两亲性物质的疏水性离子对络合物来获得溶解。 所得到的有机溶液可以进一步加工以制备药物粉末。 可生物降解的聚合物可以与药物物质和两亲物质共溶解，并且可以并入药物粉末中。 用于制备药物粉末的优选方法是使用超临界气体反溶剂如二氧化碳使有机溶液进行气体反溶剂沉淀。 还提供了一种制备具有纤维状形状的中空颗粒的方法，其将在由人或动物宿主摄取的情况下在胃中提供增强的停留时间。 还提供了新的生物相容性阳离子表面活性剂及其用途，包括将体外和体内的核酸递送入细胞以转化细胞。

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